| Early endoderm binding sites of the paradigm PTF Foxa2 are epigenetically primed by low levels of active chromatin modifications in embryonic stem cells (ESC). The data suggest that binding site selection of PTFs is directed by the chromatin environment and that chromatin opening requires collaboration of PTFs with additional transcription factors. | Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2.
Cernilogar FM, Hasenöder S, Wang Z, Scheibner K, Burtscher I, Sterr M, Smialowski P, Groh S, Evenroed IM, Gilfillan GD, Lickert H, Schotta G., Free PMC Article | 12/21/2019 |
| FXR transcriptional activity is regulated by the glucagon/protein kinase A and the FOXA2 signaling pathways, which act on FXR through phosphorylation and protein-protein interactions, respectively, to increase hepatic glucose synthesis. | The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis.
Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P. | 11/2/2019 |
| Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation. | Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation.
Lau CI, Yánez DC, Solanki A, Papaioannou E, Saldaña JI, Crompton T., Free PMC Article | 10/5/2019 |
| changes at the nuclear lamina are linked to altered Foxa2 binding, enabling opening of chromatin and de-repression of genes encoding lipid synthesis and storage targets that contribute to etiology of hepatic steatosis. | Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver.
Whitton H, Singh LN, Patrick MA, Price AJ, Osorio FG, López-Otín C, Bochkis IM., Free PMC Article | 09/14/2019 |
| studies show that the lncRNA Falcor fine-tunes the expression of Foxa2 and that disruption of the Falcor-Foxa2 transcriptional circuit results in subtle defects in lung airway epithelial homeostasis and more dramatic defects in airway regeneration after acute injury | The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration.
Swarr DT, Herriges M, Li S, Morley M, Fernandes S, Sridharan A, Zhou S, Garcia BA, Stewart K, Morrisey EE., Free PMC Article | 09/7/2019 |
| this study found that the abundance of FOXA2 was significantly lower in fibrotic livers of patients and mice treated with CCl4 than in controls. | FOXA2 alleviates CCl(4)-induced liver fibrosis by protecting hepatocytes in mice.
Wang W, Yao LJ, Shen W, Ding K, Shi PM, Chen F, He J, Ding J, Zhang X, Xie WF., Free PMC Article | 07/27/2019 |
| FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. | FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.
Camolotto SA, Pattabiraman S, Mosbruger TL, Jones A, Belova VK, Orstad G, Streiff M, Salmond L, Stubben C, Kaestner KH, Snyder EL., Free PMC Article | 04/13/2019 |
| Study compared age and tissue- specific methylation differences in the brain and spleen of young and aged mice. There were 75 hypermethylated Foxa2 binding sites across a 2.7 Mb region of chromosome 11. Hypomethylated loci were clustered around Mid1, Isoc2b and genome-wide loci with binding sites for Foxa2 and Esr1, which are known to play important roles in development and aging. | Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites.
Uli N, Michelen-Gomez E, Ramos EI, Druley TE., Free PMC Article | 02/23/2019 |
| Maturation of pancreatic beta-cells requires the cooperative function of Foxa2 and Pdx1. | Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells.
Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H., Free PMC Article | 12/22/2018 |
| Data indicate a role for forkhead box A2 (FOXA2) in regulation of adult uterine function and fertility and mice Lacking FOXA2 in the adult uterus are infertile. | Forkhead box a2 (FOXA2) is essential for uterine function and fertility.
Kelleher AM, Peng W, Pru JK, Pru CA, DeMayo FJ, Spencer TE., Free PMC Article | 04/21/2018 |
| The c.505T>C, p.S169P genetic variant occurs at the conserved forkhead DNA binding domain of the FOXA2 and causes a rare and unique clinical phenotype of hypopituitarism, CHI, dysmorphic features, liver, pancreas, heart and gastrointestinal abnormalities. | Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities.
Giri D, Vignola ML, Gualtieri A, Scagliotti V, McNamara P, Peak M, Didi M, Gaston-Massuet C, Senniappan S. | 03/24/2018 |
| Forkhead box A2regulates biliary heterogeneity during cholestatic liver injury in mouse models. | Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡.
McDaniel K, Meng F, Wu N, Sato K, Venter J, Bernuzzi F, Invernizzi P, Zhou T, Kyritsi K, Wan Y, Huang Q, Onori P, Francis H, Gaudio E, Glaser S, Alpini G., Free PMC Article | 08/12/2017 |
| Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas. | Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas.
Bonnavion R, Teinturier R, Gherardi S, Leteurtre E, Yu R, Cordier-Bussat M, Du R, Pattou F, Vantyghem MC, Bertolino P, Lu J, Zhang CX. | 05/13/2017 |
| our study demonstrates that Foxa2 is required in both alpha and beta cells for maintaining appropriate glucagon and insulin levels and for keeping glucose homeostasis. | Conditional Tissue-Specific Foxa2 Ablation in Mouse Pancreas Causes Hyperinsulinemic Hypoglycemia.
Wu Z, Fei A, Liu Y, Pan S. | 03/4/2017 |
| Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes. | Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes.
Yalley A, Schill D, Hatta M, Johnson N, Cirillo LA., Free PMC Article | 10/8/2016 |
| FoxA1, FoxA2, and LIPG control the uptake of extracellular lipids for breast cancer growth. | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.
Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ, Gomis RR., Free PMC Article | 08/27/2016 |
| The authors show herein that Nurr1 and Foxa2 interact to protect midbrain dopaminergic neurons against various toxic insults, but their expression is lost during aging and degenerative processes. | Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease.
Oh SM, Chang MY, Song JJ, Rhee YH, Joe EH, Lee HS, Yi SH, Lee SH., Free PMC Article | 01/30/2016 |
| Authors identified thousands of enhancers that are bound by the master regulators HNF4A and FOXA2 in a differentiation-dependent manner, subject to chromatin remodeling, and associated with differentially expressed target genes. | Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation.
Alder O, Cullum R, Lee S, Kan AC, Wei W, Yi Y, Garside VC, Bilenky M, Griffith M, Morrissy AS, Robertson GA, Thiessen N, Zhao Y, Chen Q, Pan D, Jones SJM, Marra MA, Hoodless PA., Free PMC Article | 07/25/2015 |
| this study demonstrates that SIRT1 controls the acetylation level of FOXA2 in a nutrient-dependent manner and in times of nutrient shortage the interaction between SIRT1 and FOXA2 is reduced. | SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner.
van Gent R, Di Sanza C, van den Broek NJ, Fleskens V, Veenstra A, Stout GJ, Brenkman AB., Free PMC Article | 01/24/2015 |
| Hh signaling upregulated FOXA2, which induced expression of MUC2, an intestinal mucin found in Barrett's esophagus, and the MUC2-processing protein AGR2 | Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.
Wang DH, Tiwari A, Kim ME, Clemons NJ, Regmi NL, Hodges WA, Berman DM, Montgomery EA, Watkins DN, Zhang X, Zhang Q, Jie C, Spechler SJ, Souza RF., Free PMC Article | 01/24/2015 |
| through interactions with FoxA2, Arx positively regulates Shh expression in the floor plate, and Shh signaling in turn activates Nkx2.2, which suppresses Arx expression. | Arx together with FoxA2, regulates Shh floor plate expression.
Cho G, Lim Y, Cho IT, Simonet JC, Golden JA., Free PMC Article | 11/8/2014 |
| studies have identified a novel TXNIP/miR-124a/FoxA2/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP and IAPP | Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2.
Jing G, Westwell-Roper C, Chen J, Xu G, Verchere CB, Shalev A., Free PMC Article | 06/28/2014 |
| The interplay of Nurr1 and Foxa2 is the crucial determinant for dopamine phenotype acquisition during midbrain dopaminergic neuron development. | Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation.
Yi SH, He XB, Rhee YH, Park CH, Takizawa T, Nakashima K, Lee SH. | 04/12/2014 |
| Nuclear HNF3beta signaling is regulated by estrogen receptors in non-tumor intestinal mucosa. | Estrogen receptor α or β loss in the colon of Min/+ mice promotes crypt expansion and impairs TGFβ and HNF3β signaling.
Hasson RM, Briggs A, Carothers AM, Davids JS, Wang J, Javid SH, Cho NL, Bertagnolli MM., Free PMC Article | 04/5/2014 |
| Nato3 induces ectopic Foxa2-positive cells and indirectly downregulates Nkx2.2 expression. | Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance.
Mansour AA, Khazanov-Zisman S, Netser Y, Klar A, Ben-Arie N. | 03/22/2014 |