| beta-arr1 has a role in promoting thrombus formation, in part through its participation in alphaIIbbeta3 signalling, but neither beta-arr1 or beta-arr2 have a role in agonist-induced platelet activation and P2Y receptors desensitisation | β-arrestin-1 participates in thrombosis and regulates integrin aIIbβ3 signalling without affecting P2Y receptors desensitisation and function.
Schaff M, Receveur N, Bourdon C, Ohlmann P, Lanza F, Gachet C, Mangin PH. | 08/18/2012 |
| The loss of alpha2betaA1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis. | The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.
Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb-Pap A, Joosten LA, van den Berg WB, Kollias G, Eckes B, Pap T. | 07/14/2012 |
| ADAP plays a role in mediating platelet activation via the collagen-binding integrin alpha(2) beta(1). | A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1).
Jarvis GE, Bihan D, Hamaia S, Pugh N, Ghevaert CJ, Pearce AC, Hughes CE, Watson SP, Ware J, Rudd CE, Farndale RW., Free PMC Article | 06/16/2012 |
| Circulating IGF-1 levels in the sera of mice lacking either alpha2beta1 or alpha11beta1 or both integrins were sharply reduced. | Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels.
Blumbach K, Niehoff A, Belgardt BF, Ehlen HW, Schmitz M, Hallinger R, Schulz JN, Brüning JC, Krieg T, Schubert M, Gullberg D, Eckes B., Free PMC Article | 04/28/2012 |
| alpha2beta1 integrin expression by HPV-transformed keratinocytes modulates squamous carcinoma growth and progression | Loss of the α2β1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro.
Tran T, Barlow B, O'Rear L, Jarvis B, Li Z, Dickeson K, Dupont W, Zutter M., Free PMC Article | 03/31/2012 |
| show that PilA binds collagen, which promotes GBS interaction with the alphabeta integrin resulting in activation of host chemokine expression and neutrophil recruitment during infection | Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration.
Banerjee A, Kim BJ, Carmona EM, Cutting AS, Gurney MA, Carlos C, Feuer R, Prasadarao NV, Doran KS., Free PMC Article | 01/21/2012 |
| Suggest that the recruitment of peripheral CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance. | Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer.
Lin Y, Wang H, Wang W, Zeng S, Zhong Y, Li DJ. | 12/24/2011 |
| Collagen I stimulates the self-renewal of embryonic stem cells mediated by Bmi-1 through alpha2beta1 integrin-dependent ILK, Notch, Gli-1, and DDR1-dependent Ras, PI3K/Akt, and ERK. | Collagen I regulates the self-renewal of mouse embryonic stem cells through α2β1 integrin- and DDR1-dependent Bmi-1.
Suh HN, Han HJ. | 11/19/2011 |
| PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis | PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.
Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. | 07/23/2011 |
| Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions. | Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin α2β1 and complement component C1q.
Xue Q, Gu C, Rivera J, Höök M, Chen X, Pozzi A, Xu Y. | 06/25/2011 |
| alpha2beta1 integrin suppresses metastasis in a clinically relevant spontaneous mouse model of breast cancer | The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer.
Ramirez NE, Zhang Z, Madamanchi A, Boyd KL, O'Rear LD, Nashabi A, Li Z, Dupont WD, Zijlstra A, Zutter MM., Free PMC Article | 02/5/2011 |
| transgenic mice have altered keratinocyte differentiation and proliferation, which results in chronic immune cell activation | Induced keratinocyte hyper-proliferation in alpha2beta1 integrin transgenic mice results in systemic immune cell activation.
Teige I, Bäcklund A, Svensson L, Kvist PH, Petersen TK, Kemp K. | 06/28/2010 |
| enhance adhesion through alpha2beta1 integrin to collagens via a PLC-dependent priming mechanism. | Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen.
Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA., Free PMC Article | 02/8/2010 |
| MMP7 shedding of syndecan-1 facilitates wound closure by causing the alpha(2)beta(1) integrin to assume a less active conformation thereby removing restrictions to migration | MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha(2)beta(1) integrin activation.
Chen P, Abacherli LE, Nadler ST, Wang Y, Li Q, Parks WC., Free PMC Article | 01/25/2010 |
| Integrin alpha2beta1 is required for endorepellin induction of tyrosine phosphatase activity. | Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.
Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV., Free PMC Article | 01/21/2010 |
| Rap1b is required for maximal GPVI-induced but not ADP-induced activation of alpha2beta1 in murine platelets. | Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation.
Wang Z, Holly SP, Larson MK, Liu J, Yuan W, Chrzanowska-Wodnicka M, White GC 2nd, Parise LV., Free PMC Article | 01/21/2010 |
| alpha(2)-, alpha(3)-, and beta(1)-integrins and E-cadherin expression in normal human lung and bronchopulmonary sequestration and congenital cystic adenomatoid malformation were evaluated using Western blot and immunohistochemistry. | Aberrant cell adhesion molecule expression in human bronchopulmonary sequestration and congenital cystic adenomatoid malformation.
Volpe MV, Chung E, Ulm JP, Gilchrist BF, Ralston S, Wang KT, Nielsen HC., Free PMC Article | 01/21/2010 |
| Ligation negatively regulates expression of genes including matrix metalloproteinases. Deletion of alpha2beta1 integrin resulted in dramatic increase in neoangiogenesis in wound microenvironment. (Alpha2beta1 integrin) | Wound healing in the alpha2beta1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression.
Grenache DG, Zhang Z, Wells LE, Santoro SA, Davidson JM, Zutter MM. | 01/21/2010 |
| Ligand-dependent removal of activated alpha2 receptors from the cell surface negatively regulates integrin function in hematopoietic cells during migration between an adhesive environment (bone marrow) & a nonadhesive one (circulating blood). | Negative regulation of activated alpha-2 integrins during thrombopoiesis.
Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, Stricker TP, Santoro SA, Kahn ML. | 01/21/2010 |
| beta2 integrins, although required for inflammatory migration in acute asthma, are dispensable for structural remodeling in chronic asthma | Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.
Banerjee ER, Jiang Y, Henderson WR Jr, Latchman Y, Papayannopoulou T., Free PMC Article | 01/21/2010 |
| analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1 | Identification of the first prokaryotic collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1.
Caswell CC, Barczyk M, Keene DR, Lukomska E, Gullberg DE, Lukomski S., Free PMC Article | 01/21/2010 |
| The CD49b-positive CD8 T cell population is a far more potent antitumor effector cell population than nonfractionated CD8 or CD49b-negative CD8 T cells; expression of CD49b (VLA-2) may serve as a surrogate marker for successful tumor vaccination. | Induction of a VLA-2 (CD49b)-expressing effector T cell population by a cell-based neuroblastoma vaccine expressing CD137L.
Yan X, Johnson BD, Orentas RJ., Free PMC Article | 01/21/2010 |
| Cell-surface expression of the alpha2beta1-integrin plays a role in the mechanism that confers cholangiocyte susceptibility to rotavirus infection | Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia.
Jafri M, Donnelly B, Allen S, Bondoc A, McNeal M, Rennert PD, Weinreb PH, Ward R, Tiao G., Free PMC Article | 01/21/2010 |
| crosstalk between c-met and the alpha2beta1 integrin may contribute to mast-cell activation in autoimmune and inflammatory disorders. | Crosstalk between the alpha2beta1 integrin and c-met/HGF-R regulates innate immunity.
McCall-Culbreath KD, Li Z, Zutter MM., Free PMC Article | 01/21/2010 |
| Ablation of alpha2beta1 resulted in strong enhancement of neovascularization of granulation tissue and sponge implants. Alpha2beta1-null fibroblasts are hampered in generating mechanical forces. | Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization.
Zweers MC, Davidson JM, Pozzi A, Hallinger R, Janz K, Quondamatteo F, Leutgeb B, Krieg T, Eckes B. | 01/21/2010 |