| Egr2-driven cell surface proteins LAG-3 and 4-1BB can identify dysfunctional tumor antigen-specific CD8(+) TIL. | The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.
Williams JB, Horton BL, Zheng Y, Duan Y, Powell JD, Gajewski TF., Free PMC Article | 08/19/2017 |
| Egr2 and Egr3 have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 and Egr3 develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 and Egr3 confer suppressive activity to CD4(+) T cells and regulate the production of inhibitory cytokines such as IL-10 and TGF-beta1. | Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.
Morita K, Okamura T, Sumitomo S, Iwasaki Y, Fujio K, Yamamoto K. | 06/24/2017 |
| Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis. | EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells.
Jin H, Won M, Shin E, Kim HM, Lee K, Bae J. | 06/3/2017 |
| In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2)early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1, NR4A2, EGR2, EGR3 and ID4 may be key genes associated with the pathogenesis of DS. | Integrated analysis of DNA methylation and RNA‑sequencing data in Down syndrome.
Zhang J, Zhou W, Liu Y, Li N. | 04/15/2017 |
| EGR2 mutation presents as an axonal Charcot-Marie-Tooth phenotype with variable severity. | The EGR2 gene is involved in axonal Charcot-Marie-Tooth disease.
Sevilla T, Sivera R, Martínez-Rubio D, Lupo V, Chumillas MJ, Calpena E, Dopazo J, Vílchez JJ, Palau F, Espinós C. | 06/28/2016 |
| MicroRNA20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing EGR2 expression. | MicroRNA‑20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing early growth response 2 expression.
Zhuo W, Ge W, Meng G, Jia S, Zhou X, Liu J., Free PMC Article | 06/28/2016 |
| These results suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of Guillain-Barre syndrome | Expression of Early Growth Response Gene-2 and Regulated Cytokines Correlates with Recovery from Guillain-Barré Syndrome.
Doncel-Pérez E, Mateos-Hernández L, Pareja E, García-Forcada Á, Villar M, Tobes R, Romero Ganuza F, Vila Del Sol V, Ramos R, Fernández de Mera IG, de la Fuente J. | 06/11/2016 |
| A recurrent mutation was identified in EGR2 which appears to be associated with the pathogenesis of schizophrenia. | Resequencing of early growth response 2 (EGR2) gene revealed a recurrent patient-specific mutation in schizophrenia.
Hu TM, Chen CH, Chuang YA, Hsu SH, Cheng MC. | 04/9/2016 |
| Knock-down of EGR2 with siRNA was demonstrated to have a similar effect as the over-expression of miR-330-3p in NSCLC cell lines | miR-330-3p controls cell proliferation by targeting early growth response 2 in non-small-cell lung cancer.
Liu X, Shi H, Liu B, Li J, Liu Y, Yu B. | 03/12/2016 |
| Dysregulated Egr-2 is observed in some human autoimmune disorders. | The roles of Egr-2 in autoimmune diseases.
Zhang M, Wang Y, Wang JS, Liu J, Liu MM, Yang HB. | 02/27/2016 |
| EGR2 knockdown inhibited proliferation, clonogenicity and spheroidal growth in vitro and induced regression of Ewing sarcoma xenografts. | Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.
Grünewald TG, Bernard V, Gilardi-Hebenstreit P, Raynal V, Surdez D, Aynaud MM, Mirabeau O, Cidre-Aranaz F, Tirode F, Zaidi S, Perot G, Jonker AH, Lucchesi C, Le Deley MC, Oberlin O, Marec-Bérard P, Véron AS, Reynaud S, Lapouble E, Boeva V, Rio Frio T, Alonso J, Bhatia S, Pierron G, Cancel-Tassin G, Cussenot O, Cox DG, Morton LM, Machiela MJ, Chanock SJ, Charnay P, Delattre O., Free PMC Article | 01/16/2016 |
| our data suggest that robust CD26 costimulatory signaling induces preferential expression of EGR2 and IL-10 as a potential mechanism for regulating CD26-mediated activation. | CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway.
Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, Dang NH, Okumura K, Morimoto C. | 04/18/2015 |
| transcription factor early growth response gene-2 is a novel molecular switch regulating known immunomodulatory molecules in human mesenchymal stem cells. | Early growth response-2 signaling mediates immunomodulatory effects of human multipotential stromal cells.
Barbeau DJ, La KT, Kim DS, Kerpedjieva SS, Shurin GV, Tamama K., Free PMC Article | 08/30/2014 |
| Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a. | Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2).
Li X, Zhang Z, Yu M, Li L, Du G, Xiao W, Yang H., Free PMC Article | 04/12/2014 |
| Lack of association of EGR2 variants with bipolar disorder in Japanese population. | Lack of association of EGR2 variants with bipolar disorder in Japanese population.
Balan S, Yamada K, Iwayama Y, Toyota T, Ohnishi T, Maekawa M, Toyoshima M, Iwata Y, Suzuki K, Kikuchi M, Ujike H, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Kato T, Yoshikawa T. | 10/19/2013 |
| EGR2 and EGR3 are regulated by NFkappaB and MAPK signalling pathways downstream of TNFalpha stimulation in breast adipose fibroblasts, and this in turn is upstream of CYP19A1 transcription via PI.4 | NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.
To SQ, Knower KC, Clyne CD. | 05/25/2013 |
| data suggest a tendency of gender-specific association of EGR2 and EGR4 in schizophrenia. | Genetic and functional analyses of early growth response (EGR) family genes in schizophrenia.
Cheng MC, Chuang YA, Lu CL, Chen YJ, Luu SU, Li JM, Hsu SH, Chen CH. | 01/26/2013 |
| Charcot-Marie-Tooth neuropathy due to a novel EGR2 gene mutation exhibits a mild phenotype in a Czech family. | Charcot-Marie-Tooth neuropathy due to a novel EGR2 gene mutation with mild phenotype--usefulness of human mapping chip linkage analysis in a Czech family.
Safka Brožková D, Nevšímalová S, Mazanec R, Rautenstrauss B, Seeman P. | 01/12/2013 |
| Egr2 expression is translationally regulated via an IRES element, which is responsive to an inflammatory environment. | IRES-dependent translation of egr2 is induced under inflammatory conditions.
Rübsamen D, Blees JS, Schulz K, Döring C, Hansmann ML, Heide H, Weigert A, Schmid T, Brüne B., Free PMC Article | 12/8/2012 |
| we report on a heterozygous mutation in EGR2 in a family with a mild demyelinating form of adult-onset Charcot-Marie-Tooth disease | A novel EGR2 mutation within a family with a mild demyelinating form of Charcot-Marie-Tooth disease.
Shiga K, Noto Y, Mizuta I, Hashiguchi A, Takashima H, Nakagawa M. | 11/3/2012 |
| Combined with a plausible biological function of EGR2, the EGR2 gene is a possible susceptibility gene in bipolar disorder. | Genetic association of the EGR2 gene with bipolar disorder in Korea.
Kim SH, Song JY, Joo EJ, Lee KY, Shin SY, Lee YH, Ahn YM, Kim YS., Free PMC Article | 06/30/2012 |
| data further demonstrate the major role of the myelinating Schwann cell element in the regulation of EGR2 expression in the human peripheral nervous system | Homozygous deletion of an EGR2 enhancer in congenital amyelinating neuropathy.
Funalot B, Topilko P, Arroyo MA, Sefiani A, Hedley-Whyte ET, Yoldi ME, Richard L, Touraille E, Laurichesse M, Khalifa E, Chauzeix J, Ouedraogo A, Cros D, Magdelaine C, Sturtz FG, Urtizberea JA, Charnay P, Bragado FG, Vallat JM. | 06/9/2012 |
| Results identify a mutation in EGR2 in a Charcot-Marie-tooth disease patient with hypersensitivity to vincristine. | Vincristine exacerbates asymptomatic Charcot-Marie-tooth disease with a novel EGR2 mutation.
Nakamura T, Hashiguchi A, Suzuki S, Uozumi K, Tokunaga S, Takashima H. | 05/26/2012 |
| Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. | Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
Postel-Vinay S, Véron AS, Tirode F, Pierron G, Reynaud S, Kovar H, Oberlin O, Lapouble E, Ballet S, Lucchesi C, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, de Paillerets BB, Laud K, Dina C, Froguel P, Clavel-Chapelon F, Doz F, Michon J, Chanock SJ, Thomas G, Cox DG, Delattre O. | 04/21/2012 |
| Krox20 functions as a SUMO ligase for its coregulators--the Nab proteins--and that Nab sumoylation negatively modulates Krox20 transcriptional activity in vivo. | The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.
García-Gutiérrez P, Juárez-Vicente F, Gallardo-Chamizo F, Charnay P, García-Domínguez M., Free PMC Article | 01/28/2012 |