| Findings indicate that diet-induced obesity exacerbates thyroid cancer progression in Thrb(PV/PV)Pten(+/-) mice and suggest that the STAT3 signaling pathway could be tested as a potential target for the treatment of thyroid cancer. | Diet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse model.
Kim WG, Park JW, Willingham MC, Cheng SY., Free PMC Article | 11/2/2013 |
| conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. | Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation.
Liu YY, Kogai T, Schultz JJ, Mody K, Brent GA., Free PMC Article | 12/29/2012 |
| mutation of a single allele of the Thrb gene is sufficient to drive the TSH-simulated hyperplastic thyroid follicular cells to undergo carcinogenesis. | Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor.
Zhao L, Zhu X, Won Park J, Fozzatti L, Willingham M, Cheng SY., Free PMC Article | 12/22/2012 |
| the differential effects of thyroid hormone receptor isoforms on Tshb expression may be based on their differential DNA-binding affinity to the promoter. | Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.
Chiamolera MI, Sidhaye AR, Matsumoto S, He Q, Hashimoto K, Ortiga-Carvalho TM, Wondisford FE., Free PMC Article | 09/22/2012 |
| 2,2',4,4'-tetrabrominated diphenyl ether could upregulate the expression of TRalpha1 and TRbeta1 in liver. | [Effects of 2,2',4,4'-tetrabrominated diphenyl ethers on the TRalpha1 and TRbeta1 expression in liver in C57BL/6 mice].
Liu Z, Liu J, Zhang J, Tian Y, Fang D, Huang H, Jiang Y, Zhou J, Zhang H, Mei S. | 08/11/2012 |
| Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor beta gene due to activation of Wnt/beta-catenin protein signaling. | Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling.
O'Shea PJ, Kim DW, Logan JG, Davis S, Walker RL, Meltzer PS, Cheng SY, Williams GR., Free PMC Article | 07/28/2012 |
| mutations in thyroid hormone receptor beta were deleterious to tectorial membrane development and led to important alterations in cochlear morphology and loss of cochlear function | Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.
Richter CP, Münscher A, Machado DS, Wondisford FE, Ortiga-Carvalho TM., Free PMC Article | 04/21/2012 |
| Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones | Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones.
Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D., Free PMC Article | 04/21/2012 |
| TRbeta receptors mediate the acute effects produced by transient changes of thyroid hormone concentrations on bone remodeling. | Thyroid hormone receptor β mediates thyroid hormone effects on bone remodeling and bone mass.
Monfoulet LE, Rabier B, Dacquin R, Anginot A, Photsavang J, Jurdic P, Vico L, Malaval L, Chassande O. | 12/17/2011 |
| The Delta337T mutation on the TRbeta causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice. | The Δ337T mutation on the TRβ causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice.
Santiago LA, Santiago DA, Faustino LC, Cordeiro A, Lisboa PC, Wondisford FE, Pazos-Moura CC, Ortiga-Carvalho TM. | 11/12/2011 |
| A role is found for thyroid hormone receptor beta in modulating hippocampal progenitor cell division. | Loss of thyroid hormone receptor β is associated with increased progenitor proliferation and NeuroD positive cell number in the adult hippocampus.
Kapoor R, Ghosh H, Nordstrom K, Vennstrom B, Vaidya VA., Free PMC Article | 11/12/2011 |
| a TRbeta mutation promotes the development of mammary hyperplasia via aberrant activation of STAT5 | Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors.
Guigon CJ, Kim DW, Willingham MC, Cheng SY., Free PMC Article | 10/1/2011 |
| Results suggest that thyroid hormone receptor beta is involved in suppression of the central component of the hypothalamic-pituitary-thyroid axis in acute illness. | Thyroid hormone receptor β mediates acute illness-induced alterations in central thyroid hormone metabolism.
Boelen A, Kwakkel J, Chassande O, Fliers E. | 06/18/2011 |
| Together, our data suggest that the action of TH via TRbeta regulates important events of cerebellar ontogenesis contributing to a better understanding of some neuroendocrine disorders. | Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.
Portella AC, Carvalho F, Faustino L, Wondisford FE, Ortiga-Carvalho TM, Gomes FC. | 06/28/2010 |
| Data indicate that impaired adipogenesis by mutant thyroid hormone receptors is isoform dependent. | Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms.
Mishra A, Zhu XG, Ge K, Cheng SY., Free PMC Article | 06/14/2010 |
| Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling | Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling.
Mascanfroni ID, Del Mar Montesinos M, Alamino VA, Susperreguy S, Nicola JP, Ilarregui JM, Masini-Repiso AM, Rabinovich GA, Pellizas CG., Free PMC Article | 05/3/2010 |
| TRs could function as tumor suppressors in a mouse model of metastatic follicular thyroid cancer. | Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma.
Zhu XG, Zhao L, Willingham MC, Cheng SY., Free PMC Article | 05/3/2010 |
| These observations raise the intriguing possibility that nuclear receptor homodimers such as thyroid hormone receptor display preferential binding to the N-CoR corepressor via their specific interactions with interaction domain ID3. | Molecular determinants required for selective interactions between the thyroid hormone receptor homodimer and the nuclear receptor corepressor N-CoR.
Kim JY, Son YL, Kim JS, Lee YC. | 03/15/2010 |
| TR beta mediates T(3) regulation of UCP1 in BAT and is required for adaptive thermogenesis. | Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis.
Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA., Free PMC Article | 03/1/2010 |
| full-length forms of both RORalpha and TR are essential for the augmentation of TR-mediated transcription by RORalpha | Retinoic Acid receptor-related orphan receptor alpha-enhanced thyroid hormone receptor-mediated transcription requires its ligand binding domain which is not, by itself, sufficient: possible direct interaction of two receptors.
Qiu CH, Miyazaki W, Iwasaki T, Londoño M, Ibhazehiebo K, Shimokawa N, Koibuchi N. | 01/21/2010 |
| The report demonstrates the in vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta. | In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice.
Alonso M, Goodwin C, Liao X, Ortiga-Carvalho T, Machado DS, Wondisford FE, Refetoff S, Weiss RE., Free PMC Article | 01/21/2010 |
| illness-induced serum T3 and T4 and liver D1 decrease takes place despite the absence of thyroid hormone receptor beta. | Lacking thyroid hormone receptor beta gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness.
Kwakkel J, Chassande O, van Beeren HC, Wiersinga WM, Boelen A. | 01/21/2010 |
| Apo-TRbeta and apo-TRalpha1 had different effects on lipid metabolism and that both TR isoforms contribute to the pathogenesis of lipid metabolism in hypothyroidism. | Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms.
Araki O, Ying H, Zhu XG, Willingham MC, Cheng SY., Free PMC Article | 01/21/2010 |
| The results indicate that TR[beta]2 identifies cones from their initial generation in the embryo to postnatal maturation stages. Expression peaks with the completion of cone generation before birth. | Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse.
Ng L, Ma M, Curran T, Forrest D., Free PMC Article | 01/21/2010 |
| The stabilization of beta-catenin, via association with a mutated TRbeta, represents a novel activating mechanism of the oncogenic protein beta-catenin that could contribute to thyroid carcinogenesis in TRbeta(PV/PV) mice. | Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor.
Guigon CJ, Zhao L, Lu C, Willingham MC, Cheng SY., Free PMC Article | 01/21/2010 |