| HHIP - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies. | Candidate genes for COPD: current evidence and research.
Kim WJ, Lee SD., Free PMC Article | 07/16/2016 |
| Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling. | Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling.
Kwong L, Bijlsma MF, Roelink H., Free PMC Article | 10/31/2015 |
| HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease. | Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples.
Shahi MH, Zazpe I, Afzal M, Sinha S, Rebhun RB, Meléndez B, Rey JA, Castresana JS., Free PMC Article | 07/25/2015 |
| HHIP is located within genes previously associated with chronic obstructive pulmonary disease susceptibility. | Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.
Castaldi PJ, Cho MH, San José Estépar R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK, COPDGene Investigators., Free PMC Article | 10/18/2014 |
| Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease. | Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease.
Kim WJ, Oh YM, Lee JH, Park CS, Park SW, Park JS, Lee SD. | 10/4/2014 |
| The data demonstrated that loss of expression of HHIP and PTCH is associated with the methylation of gene promoters | Altered expression of PTCH and HHIP in gastric cancer through their gene promoter methylation: novel targets for gastric cancer.
Song Y, Tian Y, Zuo Y, Tu JC, Feng YF, Qu CJ. | 07/26/2014 |
| We show that GPC3, an hepatocellular carcinoma biomarker and Hh mediator, regulates human stellate cell viability by regulating Hh signaling. | The glypican 3 hepatocellular carcinoma marker regulates human hepatic stellate cells via Hedgehog signaling.
Magistri P, Leonard SY, Tang CM, Chan JC, Lee TE, Sicklick JK. | 05/24/2014 |
| Data indicate that the Shh signaling transduction is facilitated by binding of Shh to its receptor protein, Ptch, and show the complex structure of Shh-Hhip. | Molecular dynamics simulations of sonic hedgehog-receptor and inhibitor complexes and their applications for potential anticancer agent discovery.
Hwang S, Thangapandian S, Lee KW., Free PMC Article | 04/26/2014 |
| our study suggests that the HHIP gene may be involved in COPD susceptibility in Chinese Han population. | Association of HHIP polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population.
Wang B, Zhou H, Yang J, Xiao J, Liang B, Li D, Zhou H, Zeng Q, Fang C, Rao Z, Yu H, Ou X, Feng Y. | 12/14/2013 |
| HHIP, HDAC4, NCR3 and RARB polymorphisms may have a role in impaired lung function that begins in early life | HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function.
Collins SA, Lucas JS, Inskip HM, Godfrey KM, Roberts G, Holloway JW, Southampton Women's Survey Study Group., Free PMC Article | 10/19/2013 |
| Identification of potential HHIP targets of gene expression regulation in chronic obstructive pulmonary disease. | Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.
Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua AA, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AM, Quackenbush J, Silverman EK., Free PMC Article | 10/19/2013 |
| These data suggest that activated Hedgehog signalling contributes to the biology of human fetal rhabdomyomas. | Mutations in Hedgehog pathway genes in fetal rhabdomyomas.
Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ., Free PMC Article | 10/19/2013 |
| Results suggest involvement of the Hedgehog pathway in CPHD and that both SHH and HHIP are investigated as a second screening in CPHD, after mutations in the classical CPHD genes have been ruled out. | Single-nucleotide variants in two Hedgehog genes, SHH and HHIP, as genetic cause of combined pituitary hormone deficiency.
Gorbenko del Blanco D, de Graaff LC, Visser TJ, Hokken-Koelega AC. | 08/10/2013 |
| no correlation between hedgehog activity and SHH, Gli1 and Patched1 mRNA levels was observed. other mechanisms aside from transcriptional regulation of these factors are responsible for hedgehog activity in tumor cells derived from GBM. | Hedgehog signaling in glioblastoma multiforme.
Braun S, Oppermann H, Mueller A, Renner C, Hovhannisyan A, Baran-Schmidt R, Gebhardt R, Hipkiss A, Thiery J, Meixensberger J, Gaunitz F. | 12/22/2012 |
| GDC-0449 treatment is pharmacodynamically effective as evidenced by paracrine Hedgehog signaling inhibition and results in prostate cancer cell proliferation reduction. | Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b.
Karlou M, Lu JF, Wu G, Maity S, Tzelepi V, Navone NM, Hoang A, Logothetis CJ, Efstathiou E., Free PMC Article | 12/8/2012 |
| Low HHIP expression is associated with chronic obstructive pulmonary disease. | Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.
Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK., Free PMC Article | 08/11/2012 |
| Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cells.( | Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell.
Mo W, Xu X, Xu L, Wang F, Ke A, Wang X, Guo C. | 07/14/2012 |
| Mutation of the hedgehog signaling patwhway play a key role in the development of basal cell carrcinomas. | The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics.
Iwasaki JK, Srivastava D, Moy RL, Lin HJ, Kouba DJ. | 06/9/2012 |
| results suggest the possibility of epigenetic regulation of HHIP in medulloblastoma | Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples.
Shahi MH, Afzal M, Sinha S, Eberhart CG, Rey JA, Fan X, Castresana JS., Free PMC Article | 10/1/2011 |
| We found that HIP, PDGFRalpha, SMO and Su(Fu) gene highly expressed in the primary esophageal squamous cell carcinomas | Identification of signature genes for detecting hedgehog pathway activation in esophageal cancer.
Yang L, Bian Y, Huang S, Ma X, Zhang C, Su X, Chen ZJ, Xie J, Zhang H., Free PMC Article | 10/1/2011 |
| A subset of normal lung function genes, including HHIP, FAM13A, and PTCH1, together predict lung function abnormalities, a measure of severity in white and African American subjects with asthma. | Importance of hedgehog interacting protein and other lung function genes in asthma.
Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Peters SP, Hawkins GA, Bleecker ER, Meyers DA., Free PMC Article | 08/13/2011 |
| the GG genotype of the rs 1489759 HHIP single-nucleotide polymorphism (SNP) and the CC genotype of the rs 2202507 GYPA SNP confers a ''protective'' effect on COPD (OR 0.59, p50.006 for HHIP and OR50.65, p50.006 for GYPA) and lung cancer. | Chromosome 4q31 locus in COPD is also associated with lung cancer.
Young RP, Whittington CF, Hopkins RJ, Hay BA, Epton MJ, Black PN, Gamble GD. | 04/2/2011 |
| The HHIP locus was associated with the systemic components of COPD and with the frequency of COPD exacerbations. | Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease.
Pillai SG, Kong X, Edwards LD, Cho MH, Anderson WH, Coxson HO, Lomas DA, Silverman EK, ECLIPSE and ICGN Investigators., Free PMC Article | 02/26/2011 |
| Genetic variation near the Hip gene was significantly associated with risk of COPD, depending on the number of pack-years of smoking. | Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study.
Van Durme YM, Eijgelsheim M, Joos GF, Hofman A, Uitterlinden AG, Brusselle GG, Stricker BH. | 10/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |