| the present study reveals a novel signaling pathway, the miR-142a-3p/miR-155-5p/E3 ubiquitin-protein ligase pellino homolog 1 axis in Methamphetamine-mediated neuroinflammation | MiR-142a-3p and miR-155-5p reduce methamphetamine-induced inflammation: Role of the target protein Peli1.
Yu G, Song Y, Xie C, Tao L, Wan F, Jiang L, Wang J, Tang J. | 04/18/2020 |
| findings suggest a nonimmune regulatory role for Peli1 in promoting microglia activation during WNV infection and identify a potentially novel host factor for flavivirus cell entry and replication. | Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection.
Luo H, Winkelmann ER, Zhu S, Ru W, Mays E, Silvas JA, Vollmer LL, Gao J, Peng BH, Bopp NE, Cromer C, Shan C, Xie G, Li G, Tesh R, Popov VL, Shi PY, Sun SC, Wu P, Klein RS, Tang SJ, Zhang W, Aguilar PV, Wang T., Free PMC Article | 09/14/2019 |
| Data suggests that miR-590-5p attenuates brain injury in Intracerebral haemorrhage mice through inhibiting Peli1 gene expression. | MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression.
Guo Q, Su H, He JB, Li HQ, Sha JJ. | 03/9/2019 |
| Peli1 has a B cell-intrinsic function to protect against lupus-like autoimmunity. Peli1 deficiency in B cells induces autoantibody production via noncanonical NF-kappaB signaling. Mechanically, Peli1 functions as an E3 ligase to associate with NF-kappaB inducing kinase (NIK) and mediates NIK Lys48 ubiquitination and degradation. | Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus.
Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S, Dai D, Luo X, Lu Q, Mao C, Zhang Y, Shen N, Li B, Huang M, Zhu X, Jin J, Cheng X, Sun SC, Xiao Y., Free PMC Article | 12/22/2018 |
| This study demonstrates Pellino 1 (PELI1) as an important modulator that exerts opposite regulatory functions on apoptosis and necroptosis, two distinct forms of regulated cell death mechanisms. | PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP.
Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar AK, Wei H, Li Y, Sun SC, Yuan J., Free PMC Article | 06/30/2018 |
| Peli1 is a proangiogenic molecule that acts downstream of VEGF-Flk-1 and restores angiogenesis and enhances skin flap survivability. | Increased survivability of ischemic skin flap tissue in Flk-1(+/-) mice by Pellino-1 intervention.
Rednam CK, Wilson RL, Selvaraju V, Rishi MT, Thirunavukkarasu M, Coca-Soliz V, Lakshmanan R, Palesty JA, McFadden DW, Maulik N. | 05/26/2018 |
| a novel miR-155-Peli1-c-Rel pathway that specifically regulates Tfh cell generation and function. | A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.
Liu WH, Kang SG, Huang Z, Wu CJ, Jin HY, Maine CJ, Liu Y, Shepherd J, Sabouri-Ghomi M, Gonzalez-Martin A, Xu S, Hoffmann A, Zheng Y, Lu LF, Xiao N, Fu G, Xiao C., Free PMC Article | 08/12/2017 |
| These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase signaling by suppressing Pellino 1-mediated K63-linked ubiquitination of cIAP2, K48-linked ubiquitination, and degradation of TRAF3. | Endotoxin Tolerance Inhibits Degradation of Tumor Necrosis Factor Receptor-Associated Factor 3 by Suppressing Pellino 1 Expression and the K48 Ubiquitin Ligase Activity of Cellular Inhibitor of Apoptosis Protein 2.
Li P, Liu H, Zhang Y, Liao R, He K, Ruan X, Gong J. | 05/27/2017 |
| Pellino1 plays an important role in the pathogenesis of myocardial infarction | Silencing of Pellino1 improves post-infarct cardiac dysfunction and attenuates left ventricular remodelling in mice.
Wu W, Hu Y, Li J, Zhu W, Ha T, Que L, Liu L, Zhu Q, Chen Q, Xu Y, Li C, Li Y. | 11/29/2014 |
| The nonredundant role of Pellino1 in immune receptor signaling is in part due to its different substrate specificity. | The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.
Huoh YS, Ferguson KM., Free PMC Article | 09/27/2014 |
| Pellino1 interacts with the transcription factor Deformed Epidermal Autoregulatory Factor 1 (DEAF1). | DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA.
Ordureau A, Enesa K, Nanda S, Le Francois B, Peggie M, Prescott A, Albert PR, Cohen P., Free PMC Article | 11/16/2013 |
| Peli1 is a microglia-specific mediator of autoimmune neuroinflammation that works by regulating Traf3 degradation | Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation.
Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen Ø, Wang X, Brink R, Cheng X, Sun SC., Free PMC Article | 07/6/2013 |
| These results demonstrate that the ligands that signal via MyD88 do not always employ the same protein kinase to activate Pellino 1 and show that the activiation of NF-kappaB and mitogen-activated protein kinases. | Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.
Goh ET, Arthur JS, Cheung PC, Akira S, Toth R, Cohen P. | 02/18/2012 |
| Peli1 as a critical factor in the maintenance of peripheral T cell tolerance and demonstrate a previously unknown mechanism of c-Rel regulation. | The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity.
Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC., Free PMC Article | 11/26/2011 |
| Pellino-1 protein may have a cellular function distinct from previously identified functions. | Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9.
Kim JH, Sung KS, Jung SM, Lee YS, Kwon JY, Choi CY, Park SH., Free PMC Article | 09/24/2011 |
| IKKepsilon/TBK1 mediate the activation of Pellino 1's E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 and TLR4 agonists. | The role of TBK1 and IKKε in the expression and activation of Pellino 1.
Smith H, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC., Free PMC Article | 04/30/2011 |
| miR-21 expression was upregulated during early stages of liver regeneration. Targeting of Peli1 by miR-21 could potentially provide the basis for a negative feedback cycle regulating NF-kappaB signaling. | MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling.
Marquez RT, Wendlandt E, Galle CS, Keck K, McCaffrey AP., Free PMC Article | 04/19/2010 |
| Peli1 is a ubiquitin ligase needed for the transmission of TRIF-dependent TLR signals. | Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production.
Chang M, Jin W, Sun SC., Free PMC Article | 01/21/2010 |