| These results show that ubiquitinated Apaf-1 may activate caspase-9 under conditions of proteasome impairment. | Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity.
Ohta E, Itoh M, Ueda M, Hida Y, Wang MX, Hayakawa-Ogura M, Li S, Nishida E, Ohta K, Tana, Islam S, Nakagawa K, Sunayama T, Chen H, Hirata S, Endo M, Ohno Y, Nakagawa T., Free PMC Article | 02/29/2020 |
| rs1052571 associated with gentamicin efficacy in treating intractable Meniere disease vertigo | CASP9 genotype confers gentamicin susceptibility in intratympanic treatment of intractable vertigo caused by Ménière's disease.
Huang CJ, Wan TK, Fang TY, Wang PC. | 12/14/2019 |
| Cytochrome c acted as an indirect activator of caspase-9 and caspase 3. | Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition.
Elena-Real CA, Díaz-Quintana A, González-Arzola K, Velázquez-Campoy A, Orzáez M, López-Rivas A, Gil-Caballero S, De la Rosa MÁ, Díaz-Moreno I., Free PMC Article | 12/7/2019 |
| HSP90 inhibitors are identified here as a pharmacological approach for targeting autophagy via destabilization of ATG7, while an induced expression of CASP9. | HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC.
Han J, Goldstein LA, Hou W, Chatterjee S, Burns TF, Rabinowich H., Free PMC Article | 10/5/2019 |
| the present study showed that lncRNA POU3F3 may promote proliferation and inhibit apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9. | LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9.
Yang J, Meng X, Yu Y, Pan L, Zheng Q, Lin W. | 07/20/2019 |
| Compared with GG genotype carriers, AA genotype carriers had a statistically significant difference in the expression of caspase-9 in nucleus pulposus. There was no correlation between the MRI score of lumbar disc degeneration and the expression of caspase-9 in the degenerated nucleus pulposus. | [Caspase-9 (-Ex5+32 G/A) gene polymorphism is associated with caspase-9 expression in degenerative nucleus pulposus of lumbar intervertebral disc].
Jin Z, Liu Z, Xu C, Yang J, Xu H, Chang Y, Dong X, Wu X, Sun Z. | 07/13/2019 |
| Results strongly suggest that rare mutations in apoptosis-related genes including CASP9, APAF1, and CASP3 contribute to etiology of neural tube defects in Han Chinese population. | Rare mutations in apoptosis related genes APAF1, CASP9, and CASP3 contribute to human neural tube defects.
Zhou X, Zeng W, Li H, Chen H, Wei G, Yang X, Zhang T, Wang H., Free PMC Article | 06/15/2019 |
| Serum CASP9 levels were significantly lower in the patients group than in the control group (p<0.0001). CASP9 Ex5+32 GG genotype was a risk factor whereas the variant A allele could be a risk-reducing factor for Non-small cell lung cancer . | Investigation of Caspase 9 Gene Polymorphism in Patients With Non-small Cell Lung Cancer.
Ercan S, Arinc S, Yilmaz SG, Altunok C, Yaman F, Isbir T. | 05/25/2019 |
| Gallium complexes significantly depleted cellular iron, resulting in upregulation of transferrin receptor-1 and downregulation of ferritin. They also effectively activate the caspase family proteins (caspase-3/7/9), promote the release of cytochromes from the mitochondria, and ultimately lead to apoptosis. | Gallium(III) complexes of α-N-heterocyclic piperidylthiosemicarbazones: Synthesis, structure-activity relationship, cellular uptake and activation of caspases-3/7/9.
Qi J, Yao Q, Qian K, Tian L, Cheng Z, Wang Y. | 05/18/2019 |
| Inhibition of TRIAP1 in RPMI8226 cells increased the percentage of apoptotic cells, accompanied by increased expression of APAF1 and Caspase 9, and Caspase 9 and Caspase 3/7 activity. | TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1) stable silencing increases late apoptosis by upregulation of caspase 9 and APAF1 in RPMI8226 multiple myeloma cell line.
Fook-Alves VL, de Oliveira MB, Zanatta DB, Strauss BE, Colleoni GW. | 05/11/2019 |
| This effect was mediated by an increase in the expression of genes encoding p21, p27, caspase 3, caspase 9 as well a decrease in transcription of AKT1 and S6K1. | Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway.
Kapral M, Wawszczyk J, Jesse K, Paul-Samojedny M, Kuśmierz D, Węglarz L., Free PMC Article | 02/9/2019 |
| Mechanistic insights into a new level of caspase-9 regulation, prompting speculation that the CARD may also play a role in the recruitment or recognition of substrate. | Caspase-9 CARD : core domain interactions require a properly formed active site.
Huber KL, Serrano BP, Hardy JA., Free PMC Article | 01/12/2019 |
| CASP9 mutations cause recurrent folate-resistant neural tube defects. | Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects.
Spellicy CJ, Norris J, Bend R, Bupp C, Mester P, Reynolds T, Dean J, Peng Y, Alexov E, Schwartz CE, Stevenson RS, J Friez M., Free PMC Article | 12/22/2018 |
| Study described rare mutations of the apoptosis gene CASP9 identified in neural tube defect cases and demonstrated that the p.Y251C variant impairs the protein's apoptotic function, suggesting it is a loss-of-function variation; also showed that the p.R191G variant inhibited apoptosis under folate-deficient condition, highlighting the effect of gene-environment interactions in this complex disease. | Genetic screening and functional analysis of CASP9 mutations in a Chinese cohort with neural tube defects.
Liu XZ, Zhang Q, Jiang Q, Bai BL, Du XJ, Wang F, Wu LH, Lu XL, Bao YH, Li HL, Zhang T., Free PMC Article | 12/22/2018 |
| these results revealed that caspase9 and activated caspase3 predominantly regulates cell apoptosis in human dental pulp stem cells from deciduous teeth. | Caspase‑9 was involved in cell apoptosis in human dental pulp stem cells from deciduous teeth.
Qian H, Huang Q, Chen YX, Liu Q, Fang JX, Ye MW. | 10/20/2018 |
| Low CASP9 expression is associated with Colorectal Cancer. | Expression Level of Caspase Genes in Colorectal Cancer.
Asadi M, Shanehbandi D, Asvadi Kermani T, Sanaat Z, Zafari V, Hashemzadeh S., Free PMC Article | 10/20/2018 |
| the results of the present study suggest that miR-96-5p, which is frequently upregulated in hepatocellular carcinoma (HCC), inhibits apoptosis by targeting CASP9. Therefore, miR-96-5p may be a potential therapeutic target for HCC | Oncogenic miR-96-5p inhibits apoptosis by targeting the caspase-9 gene in hepatocellular carcinoma.
Iwai N, Yasui K, Tomie A, Gen Y, Terasaki K, Kitaichi T, Soda T, Yamada N, Dohi O, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y. | 10/6/2018 |
| CASP9 germline mutations may have played a role at least in part to the susceptibility of development of gliomas in a Li-Fraumeni-like family lacking a TP53 germline mutation. | CASP9 germline mutation in a family with multiple brain tumors.
Ronellenfitsch MW, Oh JE, Satomi K, Sumi K, Harter PN, Steinbach JP, Felsberg J, Capper D, Voegele C, Durand G, McKay J, Le Calvez-Kelm F, Schittenhelm J, Klink B, Mittelbronn M, Ohgaki H., Free PMC Article | 09/22/2018 |
| The caspase 9 level was significantly lower and related with oxidant status in patients with polycystic ovary syndrome, while the circulating levels of caspases 3 and 7 were statistically similar in both PCOS and control groups. | Circulating levels of apoptotic markers and oxidative stress parameters in women with polycystic ovary syndrome: a case-controlled descriptive study.
Uyanikoglu H, Sabuncu T, Dursun H, Sezen H, Aksoy N. | 06/23/2018 |
| Results indicate that the apoptotic protease-activating factor 1 (Apaf-1) apoptosome activates caspase-9 in part through sequestration of the inhibitory caspase recruitment domains (CARDs) domain. | Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.
Li Y, Zhou M, Hu Q, Bai XC, Huang W, Scheres SH, Shi Y., Free PMC Article | 05/12/2018 |
| 1,4-BQ evidently induced mitochondria-mediated apoptosis and increased pro-apoptotic genes (Caspase-9 and Caspase-3) expression in a dose-dependent manner. | MiR-133a regarded as a potential biomarker for benzene toxicity through targeting Caspase-9 to inhibit apoptosis induced by benzene metabolite (1,4-Benzoquinone).
Chen Y, Sun P, Bai W, Gao A. | 03/24/2018 |
| DES1 plays a key role in palmitic acid-mediated caspase 9 and caspase 3 activation. | Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis.
Zhu Q, Yang J, Zhu R, Jiang X, Li W, He S, Jin J. | 03/3/2018 |
| CASP9 expression associated with inhibition of miR-182. | Inducing cell proliferative prevention in human acute promyelocytic leukemia by miR-182 inhibition through modulation of CASP9 expression.
Fasihi-Ramandi M, Moridnia A, Najafi A, Sharifi M. | 02/17/2018 |
| CASP-9 polymorphism is associated with Primary Brain Tumors. | Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors.
Ozdogan S, Kafadar A, Yilmaz SG, Timirci-Kahraman O, Gormus U, Isbir T. | 10/28/2017 |
| Fisetin inhibited Triple-Negative Breast Cancer Cells cell division and induced apoptosis, which was associated with mitochondrial membrane permeabilization and the activation of caspase-9 and caspase-8, as well as the cleavage of poly(ADP-ribose) polymerase-1. | The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells.
Smith ML, Murphy K, Doucette CD, Greenshields AL, Hoskin DW. | 09/16/2017 |