| both at molecular and protein levels CXCL10 and CXCL12 significantly increased only when cells were differentiated on calcium phosphate-coated slides | Human osteoclasts express different CXC chemokines depending on cell culture substrate: molecular and immunocytochemical evidence of high levels of CXCL10 and CXCL12.
Grassi F, Piacentini A, Cristino S, Toneguzzi S, Cavallo C, Facchini A, Lisignoli G. | 01/21/2010 |
| IP10 inhibits viral replication through the induction of host cell death via a p53-mediated apoptotic pathway. | Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression.
Zhang HM, Yuan J, Cheung P, Chau D, Wong BW, McManus BM, Yang D., Free PMC Article | 01/21/2010 |
| Increase in serum CXCL10 with advancing age. | Age-dependent changes in CXC chemokine ligand 10 serum levels in euthyroid subjects.
Antonelli A, Rotondi M, Fallahi P, Romagnani P, Ferrari SM, Ferrannini E, Serio M. | 01/21/2010 |
| GGTT haplotype of CXCL10 gene is not susceptibility factor for development of multiple sclerosis(MS), but is probably to influence the course of MS, possibly contributing to slow down disease progression. | CXCL10 haplotypes and multiple sclerosis: association and correlation with clinical course.
Galimberti D, Scalabrini D, Fenoglio C, Comi C, De Riz M, Venturelli E, Lovati C, Mariani C, Monaco F, Bresolin N, Scarpini E. | 01/21/2010 |
| infection with cytomegalovirus was found to elicit the production of CXCL10 from primary microglial cells but not from astrocytes; CXCL10 production was regulated by human and viral interleukin-10 | CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10.
Cheeran MC, Hu S, Sheng WS, Peterson PK, Lokensgard JR., Free PMC Article | 01/21/2010 |
| Increased expression of the interferon-induced angiostatic ELR- CXC chemokines is a feature of juvenile DM that parallels the degree of vasculopathy in patients with the disease. | Association between lack of angiogenic response in muscle tissue and high expression of angiostatic ELR-negative CXC chemokines in patients with juvenile dermatomyositis: possible link to vasculopathy.
Fall N, Bove KE, Stringer K, Lovell DJ, Brunner HI, Weiss J, Higgins GC, Bowyer SL, Graham TB, Thornton S, Grom AA. | 01/21/2010 |
| expression in serum and liver highest in chronic hepatitis C and correlates with accumulation of Il-18 and INFgamma mRNA in chronic hepatitis C, but not in hepatitis B nor in nonviral liver disorders | Expression of the chemokine IP-10 correlates with the accumulation of hepatic IFN-gamma and IL-18 mRNA in chronic hepatitis C but not in hepatitis B.
Mihm S, Schweyer S, Ramadori G. | 01/21/2010 |
| 17beta-estradiol inhibited interferon-gamma-induced interferon-induced protein of 10 kDa secretion, mRNA expression, and promoter activity in keratinocytes; effects may be mediated by cell surface receptors | 17beta-estradiol inhibits the production of interferon-induced protein of 10 kDa by human keratinocytes.
Kanda N, Watanabe S. | 01/21/2010 |
| increased CXCL10 especially in hypothyroid patients with a more aggressive disorder, and normal CCL2 serum levels in autoimmune thyroiditis | Increase of interferon-gamma inducible alpha chemokine CXCL10 but not beta chemokine CCL2 serum levels in chronic autoimmune thyroiditis.
Antonelli A, Rotondi M, Fallahi P, Romagnani P, Ferrari SM, Paolicchi A, Ferrannini E, Serio M. | 01/21/2010 |
| Leishmania promastigotes release a granulocyte chemotactic factor and inhibit gamma-interferon-inducible protein 10 production by neutrophil granulocyte | Leishmania promastigotes release a granulocyte chemotactic factor and induce interleukin-8 release but inhibit gamma interferon-inducible protein 10 production by neutrophil granulocytes.
van Zandbergen G, Hermann N, Laufs H, Solbach W, Laskay T., Free PMC Article | 01/21/2010 |
| Pretransplant serum CXCL10 levels might represent a clinically useful parameter to identify subjects who are at high risk of severe rejection and graft failure. | High pretransplant serum levels of CXCL10/IP-10 are related to increased risk of renal allograft failure.
Rotondi M, Rosati A, Buonamano A, Lasagni L, Lazzeri E, Pradella F, Fossombroni V, Cirami C, Liotta F, La Villa G, Serio M, Bertoni E, Salvadori M, Romagnani P. | 01/21/2010 |
| TRAIL pretreatment of endothelial cells down-modulated mRNA steady-state levels of several TNF-alpha-induced chemokines, and it abrogated the TNF-alpha-mediated up-regulation of CCL8 and CXCL10, modulating leukocyte/endothelial cell adhesion | TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release.
Secchiero P, Corallini F, di Iasio MG, Gonelli A, Barbarotto E, Zauli G. | 01/21/2010 |
| These results suggest that inhibition of the CXCL10/CXCR3 axis offers a novel target for the treatment of asthma. | The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle.
Brightling CE, Ammit AJ, Kaur D, Black JL, Wardlaw AJ, Hughes JM, Bradding P. | 01/21/2010 |
| IP-10 was increased in lung tissue from patients who died of SARS | Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome.
Tang NL, Chan PK, Wong CK, To KF, Wu AK, Sung YM, Hui DS, Sung JJ, Lam CW., Free PMC Article | 01/21/2010 |
| This CXCR3 ligand has the ability to activate biochemical (e.g., PtdIns 3-kinase and MAP kinase activation) and functional events in intestinal myofibroblasts. | The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G alpha i-independent signaling and actin responses in human intestinal myofibroblasts.
Kouroumalis A, Nibbs RJ, Aptel H, Wright KL, Kolios G, Ward SG. | 01/21/2010 |
| IP-10 mRNA is stabilized by RNA-binding proteins in monocytes treated with S100b | Interferon-gamma-inducible protein (IP)-10 mRNA stabilized by RNA-binding proteins in monocytes treated with S100b.
Shanmugam N, Ransohoff RM, Natarajan R. | 01/21/2010 |
| Uregulation of IP-10 during infection of the islets in vivo is the first step towards destructive insulitis. | Induction of the chemokine interferon-gamma-inducible protein-10 in human pancreatic islets during enterovirus infection.
Berg AK, Korsgren O, Frisk G. | 01/21/2010 |
| Preterm infants have the ability to induce a robust chemokine and cytokine response during sepsis, and IP-10 is a sensitive early marker of infection. | IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants.
Ng PC, Li K, Chui KM, Leung TF, Wong RP, Chu WC, Wong E, Fok TF. | 01/21/2010 |
| Increased levels of CXCL10 in cerebrospinal fluid were found in a subgroup of MS patients. | Expression of chemokine receptors in the different clinical forms of multiple sclerosis.
Martínez-Cáceres EM, Espejo C, Brieva L, Pericot I, Tintoré M, Sáez-Torres I, Montalban X. | 01/21/2010 |
| IFNgamma stimulates the production of IP-10 and Mig in the SS ductal epithelium, and that IP-10 and Mig are involved in the accumulation of T cell infiltrates in the SS salivary gland. | Involvement of the interferon-gamma-induced T cell-attracting chemokines, interferon-gamma-inducible 10-kd protein (CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions of patients with Sjögren's syndrome.
Ogawa N, Ping L, Zhenjun L, Takada Y, Sugai S. | 01/21/2010 |
| MIG and IP-10 are cleaved by gelatinase B and neutrophil collagenase | Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.
Van den Steen PE, Husson SJ, Proost P, Van Damme J, Opdenakker G. | 01/21/2010 |
| Production by endometrial stromal cells is regulated by inflammatory mediators; Level may regulate leukocyte trafficking in the endometrium | Expression of interferon-gamma-inducible protein-10 in human endometrial stromal cells.
Kai K, Nasu K, Nakamura S, Fukuda J, Nishida M, Miyakawa I. | 01/21/2010 |
| CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11. | CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
Xanthou G, Duchesnes CE, Williams TJ, Pease JE. | 01/21/2010 |
| Chronic production of CXCL10 does not alter synaptic plasticity in CXCL10 transgenic (TG)mouse hippocampal slices. By contrast, exogenous recombinant CXCL10 significantly inhibits long-term potentiation in slices from normal C57Bl/6J and CXCL10 TG mice. | Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices.
Vlkolinský R, Siggins GR, Campbell IL, Krucker T. | 01/21/2010 |
| These data indicate that IFN-gamma mediates the recruitment of lymphocytes into the lung via production of the chemokine CXCL10, resulting in Tc1-cell alveolitis and granuloma formation. | CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis.
Agostini C, Calabrese F, Poletti V, Marcer G, Facco M, Miorin M, Cabrelle A, Baesso I, Zambello R, Trentin L, Semenzato G., Free PMC Article | 01/21/2010 |