| integrin alpha2beta1 plays a role in stabilizing murine thrombi, likely by enhancing GPVI activation and thromboxane A(2) release. | Role of murine integrin alpha2beta1 in thrombus stabilization and embolization: contribution of thromboxane A2.
Kuijpers MJ, Pozgajova M, Cosemans JM, Munnix IC, Eckes B, Nieswandt B, Heemskerk JW. | 01/21/2010 |
| VEGF-A induced alpha1 & alpha2 integrins, promoting lymphatic endothelial tube formation & haptotactic migration. Lineage-specific integrin receptor expression contribute to the distinct dynamics of wound-associated angiogenesis & lymphangiogenesis. | VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins.
Hong YK, Lange-Asschenfeldt B, Velasco P, Hirakawa S, Kunstfeld R, Brown LF, Bohlen P, Senger DR, Detmar M. | 01/21/2010 |
| platelet aggregation response to collagen correlates with alpha(2) expression; alpha(2)beta(1) participates in signaling during platelet activation | Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen.
Li TT, Larrucea S, Souza S, Leal SM, López JA, Rubin EM, Nieswandt B, Bray PF., Free PMC Article | 01/21/2010 |
| extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway | Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation.
Laplante P, Raymond MA, Labelle A, Abe J, Iozzo RV, Hébert MJ. | 01/21/2010 |
| studies establish platelet-collagen responses under physiologic flow as the consequence of a close partnership between 2 structurally distinct receptors, glycoprotein VI and integrin alpha2beta1 | GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow.
Sarratt KL, Chen H, Zutter MM, Santoro SA, Hammer DA, Kahn ML., Free PMC Article | 01/21/2010 |
| that alpha 2 beta 1 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection. | Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin.
Edelson BT, Li Z, Pappan LK, Zutter MM. | 01/21/2010 |
| CD44+alpha2beta1+ cell population is enriched in tumor-initiatin prostate cancer cells | Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells.
Patrawala L, Calhoun-Davis T, Schneider-Broussard R, Tang DG. | 01/21/2010 |
| alpha2beta1 integrin is a novel receptor for multiple collectins and the C1q complement protein | Novel collectin/C1q receptor mediates mast cell activation and innate immunity.
Edelson BT, Stricker TP, Li Z, Dickeson SK, Shepherd VL, Santoro SA, Zutter MM., Free PMC Article | 01/21/2010 |
| The distribution of GPIa (C807T/G873A) and HPA-3 genotypes did not differ significantly between normal subjects and coronary artery disease subjects | Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population.
Park S, Park HY, Park C, Ko YG, Im EK, Jo I, Shin C, Lee JB, Shim WH, Cho SY, Jang Y. | 01/21/2010 |
| Although the inflammatory properties of the CD49b-expressing subset of memory T helper cells are protective against intracellular bacterial infection, they are associated with immunopathology in acute viral infection. | Functional specialization of memory Th cells revealed by expression of integrin CD49b.
Kassiotis G, Gray D, Kiafard Z, Zwirner J, Stockinger B. | 01/21/2010 |
| Integrin alpha 2 is rapidly induced and expressed on effector CD8+ T cells; its blockade inhibits adoptive transfer of antigen-specific delayed-type hypersensitivity responses. | Expression and functional importance of collagen-binding integrins, alpha 1 beta 1 and alpha 2 beta 1, on virus-activated T cells.
Andreasen SØ, Thomsen AR, Koteliansky VE, Novobrantseva TI, Sprague AG, de Fougerolles AR, Christensen JP. | 01/21/2010 |
| decreased surface alpha2beta1 results from decreased Itga2 pre-mRNA splicing regulated by hnRNP L and depends on CA repeat length at a specific site in intron 1 | hnRNP L regulates differences in expression of mouse integrin alpha2beta1.
Cheli Y, Kunicki TJ., Free PMC Article | 01/21/2010 |
| Results describe the role of alpha2beta1 integrin in the interactions of primary fibroblasts and keratinocytes with the extracellular matrix. | Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin.
Zhang ZG, Bothe I, Hirche F, Zweers M, Gullberg D, Pfitzer G, Krieg T, Eckes B, Aumailley M. | 01/21/2010 |
| high level expression of alpha2 selectively marks a subset of primitive hematopoietic cells which retains multilineage reconstitution potential but exhibits reduced self-renewal capacity | Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells.
Wagers AJ, Weissman IL. | 01/21/2010 |
| Integrins may play an important role in lamellipodia formation. | Distinct but critical roles for integrin alphaIIbbeta3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin.
Thornber K, McCarty OJ, Watson SP, Pears CJ. | 01/21/2010 |