| SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. | SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait.
Wu S, Näär AM., Free PMC Article | 10/31/2020 |
| Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome. | Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome.
Wang H, Humbatova A, Liu Y, Qin W, Lee M, Cesarato N, Kortüm F, Kumar S, Romano MT, Dai S, Mo R, Sivalingam S, Motameny S, Wu Y, Wang X, Niu X, Geng S, Bornholdt D, Kroisel PM, Tadini G, Walter SD, Hauck F, Girisha KM, Calza AM, Bottani A, Altmüller J, Buness A, Yang S, Sun X, Ma L, Kutsche K, Grzeschik KH, Betz RC, Lin Z., Free PMC Article | 10/24/2020 |
| SREBP1 as a potential biomarker predicts levothyroxine efficacy of differentiated thyroid cancer. | SREBP1 as a potential biomarker predicts levothyroxine efficacy of differentiated thyroid cancer.
Li C, Peng X, Lv J, Zou H, Liu J, Zhang K, Li Z. | 10/24/2020 |
| Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1. | Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1.
Zhou JP, Ren YD, Xu QY, Song Y, Zhou F, Chen MY, Liu JJ, Chen LG, Pan JS., Free PMC Article | 09/26/2020 |
| Disruption of Cancer Metabolic SREBP1/miR-142-5p Suppresses Epithelial-Mesenchymal Transition and Stemness in Esophageal Carcinoma. | Disruption of Cancer Metabolic SREBP1/miR-142-5p Suppresses Epithelial-Mesenchymal Transition and Stemness in Esophageal Carcinoma.
Huang CM, Huang CS, Hsu TN, Huang MS, Fong IH, Lee WH, Liu SC., Free PMC Article | 08/22/2020 |
| our data suggested that mTORC1 upregulates SREBP1 transcription via crosstalk with the STAT5 pathway which contributes to the nonalcoholic fatty liver disease (NAFLD)-related HCC pathogenesis. And the inhibitor of SREBP1 and mTOR may help to prevent Hepatocellular carcinoma (HCC) in clinical NAFLD patients. | mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma.
Li T, Weng J, Zhang Y, Liang K, Fu G, Li Y, Bai X, Gao Y., Free PMC Article | 08/1/2020 |
| our study reveals the crucial role of miR-18a-5p and SREBP1 in the EMT and metastasis, thus providing promising drug targets for tailored therapy in the advanced breast cancer setting. | SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q., Free PMC Article | 07/11/2020 |
| post-transcriptional regulation by Lin28A/B enhances de novo fatty acid synthesis and metabolic conversion of saturated and unsaturated fatty acids via SREBP-1, which is critical for cancer progression. | Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H., Free PMC Article | 05/16/2020 |
| Downregulation of SREBP inhibits tumor growth and initiation by altering cellular lipid metabolism in colon cancer. | Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer.
Wen YA, Xiong X, Zaytseva YY, Napier DL, Vallee E, Li AT, Wang C, Weiss HL, Evers BM, Gao T., Free PMC Article | 04/11/2020 |
| SREBP1 was overexpressed in chemoresistant CRC samples, and that SREBP1 overexpression was correlated with poorer patient survival. | Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation.
Shen W, Xu T, Chen D, Tan X., Free PMC Article | 03/28/2020 |
| Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c. | Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c.
Dong Q, Majumdar G, O'Meally RN, Cole RN, Elam MB, Raghow R. | 03/21/2020 |
| the association of the SREBF1c and SREBF2 SNPs with risk of developing ACS and with triglyceride levels in a Mexican population | SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population.
Vargas-Alarcon G, Gonzalez-Pacheco H, Perez-Mendez O, Posadas-Sanchez R, Cardoso-Saldaña G, Ramirez-Bello J, Escobedo G, Nieto-Lima B, Fragoso JM., Free PMC Article | 03/14/2020 |
| Down-regulation of SREBP-1 in circulating leukocytes is a risk factor for atherosclerosis. | Down-regulated of SREBP-1 in circulating leukocyte is a risk factor for atherosclerosis: a case control study.
Peng C, Lei P, Li X, Xie H, Yang X, Zhang T, Cao Z, Zhang J., Free PMC Article | 03/7/2020 |
| Oxidized low-density lipoprotein induced SREBP-1 upregulation and lipid accumulation mediated through activation of Reactive Oxygen Species levels, NLRP3 and IL-1beta. | Sterol regulatory element binding protein (SREBP) -1 mediates oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation through NLRP3 inflammasome activation.
Varghese JF, Patel R, Yadav UCS. | 02/29/2020 |
| Low irisin and SREBP1-c levels may favor development of gestational diabetes mellitis in pregnant subjects. Further, low irisin and SREBP1-c levels in mature breast milk may act as a continued stressor from fetal to infant life as long as breast-feeding is continued. | Colostrum and mature breast milk analysis of serum irisin and sterol regulatory element-binding proteins-1c in gestational diabetes mellitus.
Fatima SS, Khalid E, Ladak AA, Ali SA. | 02/1/2020 |
| Our results indicate that SREBP1-autophagy axis plays a crucial role in tumor progression induced by high glucose microenvironment. SREBP1 may represent a novel target for pancreatic cancer prevention and treatment. | High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer.
Zhou C, Qian W, Li J, Ma J, Chen X, Jiang Z, Cheng L, Duan W, Wang Z, Wu Z, Ma Q, Li X., Free PMC Article | 12/21/2019 |
| Our results suggest that SREBP1 can promote the invasion and metastasis of CRC cells by means of promoting the expression of MMP7 related to phosphorylation of p65. | SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation.
Gao Y, Nan X, Shi X, Mu X, Liu B, Zhu H, Yao B, Liu X, Yang T, Hu Y, Liu S., Free PMC Article | 12/21/2019 |
| cholesterol loading decreased translocation of sterol regulatory element-binding protein1 (SREBP1) to the nucleolus, and the genetic expression of FAS and ACC-1, which promoted the proliferation, migration, and the invasion of SK hep1 cells. | Cholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis.
Zhao Z, Zhong L, He K, Qiu C, Li Z, Zhao L, Gong J. | 11/9/2019 |
| LMP1 activation of SREBP1-mediated lipogenesis promotes tumor cell growth and is involved in EBV-driven nasopharyngeal carcinoma pathogenesis. | Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma.
Lo AK, Lung RW, Dawson CW, Young LS, Ko CW, Yeung WW, Kang W, To KF, Lo KW., Free PMC Article | 10/26/2019 |
| Sirtuin 1/ forkhead transcription factor 1/sterol regulatory element binding transcription factor 1 act as a pathway targeting progesterone receptor and involve in the development of progestin resistance in Ishikawa cells | Roles of SIRT1/FoxO1/SREBP-1 in the development of progestin resistance in endometrial cancer.
Wang Y, Zhang L, Che X, Li W, Liu Z, Jiang J. | 09/14/2019 |
| Polymorphism of SREBF1 gene rs11868035 may increase susceptibility to Parkinson's disease in the northeastern Chinese population, while variant of USP25 gene rs2823357 may have no association with susceptibility to Parkinson's disease in northeastern Chinese. | The polymorphism of SREBF1 gene rs11868035 G/A is associated with susceptibility to Parkinson's disease in a Chinese population.
Lou F, Li M, Liu N, Li X, Ren Y, Luo X. | 09/7/2019 |
| Data define an AR/mTOR nuclear axis, in the context of prostate cancer, as a novel pathway regulating SREBF1 activity and citrate metabolism.The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth. | SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer.
Audet-Walsh É, Vernier M, Yee T, Laflamme C, Li S, Chen Y, Giguère V. | 08/31/2019 |
| Results show that CVB3 2A protein promoted the transcriptional activities of SREBP1a, which are mediated by the SP1 transcription factor. Also, MEK/ERK signaling pathway is critical for 2A-induced SREBP1a activation and lipid accumulation. SREBP1 promoted lipid accumulation and CVB3 virus replication. | CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway.
Wang L, Xie W, Zhang L, Li D, Yu H, Xiong J, Peng J, Qiu J, Sheng H, He X, Zhang K., Free PMC Article | 08/31/2019 |
| The coexpression of HDGF and SREBP-1 is positively correlated with poor prognosis in hepatocellular carcinoma patients. HDGF and SREBP-1 synergistically promote hepatocellular carcinoma development by activating lipid biosynthesis. The HDGF/SREBP-1 axis might be used to develop new diagnostic and therapeutic targets. | Role of hepatoma-derived growth factor in promoting de novo lipogenesis and tumorigenesis in hepatocellular carcinoma.
Min X, Wen J, Zhao L, Wang K, Li Q, Huang G, Liu J, Zhao X., Free PMC Article | 08/24/2019 |
| SREBF1-miR-33b axis affects both lipid profiles and macrophage phenotype remodeling, promoting the development of atherosclerosis. | SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo.
Nishino T, Horie T, Baba O, Sowa N, Hanada R, Kuwabara Y, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Ide Y, Koyama S, Kimura M, Nagata M, Yoshida K, Takagi Y, Nakamura T, Hasegawa K, Miyamoto S, Kimura T, Ono K. | 08/10/2019 |