| A role for NF-kappaB noncanonical pathway activation in modulating diabetes-induced inflammation in renal tubular epithelium. | NF-κB-inducing kinase increases renal tubule epithelial inflammation associated with diabetes.
Zhao Y, Banerjee S, LeJeune WS, Choudhary S, Tilton RG., Free PMC Article | 12/17/2011 |
| Adiponectin treatment inhibited NIK-induced NF-kappaB activation and restored insulin sensitivity by restoring phosphatidylinositol 3 kinase activation and subsequent serine-threonine kinase phosphorylation. | NF-kappaB-inducing kinase (NIK) mediates skeletal muscle insulin resistance: blockade by adiponectin.
Choudhary S, Sinha S, Zhao Y, Banerjee S, Sathyanarayana P, Shahani S, Sherman V, Tilton RG, Bajaj M., Free PMC Article | 11/12/2011 |
| findings suggest that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-kappaB pathway genes, including CXCL10 | A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock.
Thair SA, Walley KR, Nakada TA, McConechy MK, Boyd JH, Wellman H, Russell JA. | 06/18/2011 |
| plays a key role in constitutive NF-kappaB activation in non-small cell lung cancer cells | Overexpression of NF-κB inducing kinase underlies constitutive NF-κB activation in lung cancer cells.
Saitoh Y, Martínez Bruyn VJ, Uota S, Hasegawa A, Yamamoto N, Imoto I, Inazawa J, Yamaoka S. | 06/18/2011 |
| TNF-alpha and carrageenan in combination act to increase NIK phosphorylation, thereby increasing activation of the non-canonical pathway of NF-kappaB activation | Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan.
Bhattacharyya S, Dudeja PK, Tobacman JK., Free PMC Article | 01/15/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article | 12/5/2010 |
| Data suggest that NIK and genes induced by the NIK-mediated constitutive NF-kappaB activation could be therapeutic targets of basal-like breast cancer. | Epigenetic alteration of the NF-κB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer.
Yamamoto M, Ito T, Shimizu T, Ishida T, Semba K, Watanabe S, Yamaguchi N, Inoue J., Free PMC Article | 12/4/2010 |
| Lipopolysaccharide induces activation of both canonical and non-canonical pathways of NF-kappaB and the non-canonical pathway requires phosphorylations of BCL10 (serine 138) and NIK. | Lipopolysaccharide-induced activation of NF-κB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations.
Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK., Free PMC Article | 11/13/2010 |
| An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. | An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination.
Jin X, Jin HR, Jung HS, Lee SJ, Lee JH, Lee JJ., Free PMC Article | 10/30/2010 |
| Data show that NIK with mutations in the IKKalpha-targeted serine residues was more stable than wild-type NIK and resulted in increased noncanonical NF-kappaB signaling. | Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G., Free PMC Article | 08/23/2010 |
| These results suggest that augmentation of NF-kappaB-inducing kinase, IkappaB kinase-alpha, and pH3 in response to oxidative stress is involved in cell death after cerebral ischemia (or stroke). | Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia.
Song YS, Kim MS, Kim HA, Jung BI, Yang J, Narasimhan P, Kim GS, Jung JE, Park EH, Chan PH., Free PMC Article | 07/26/2010 |
| the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase | Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor.
Sanjo H, Zajonc DM, Braden R, Norris PS, Ware CF., Free PMC Article | 06/28/2010 |
| Data provide analysis of the IKK/NIK inter-relationship and its impact on NF-kappaB control by mathematical modelling. | NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.
Kim HB, Evans I, Smallwood R, Holcombe M, Qwarnstrom EE. | 05/3/2010 |
| These findings indicate an upstream signaling role for BCL10, in addition to its effects on IKKgamma, the regulatory component of the IKK signalosome, and a requirement for BCL10 in both canonical and noncanonical pathways of NF-kappaB activation. | B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation.
Bhattacharyya S, Borthakur A, Tyagi S, Gill R, Chen ML, Dudeja PK, Tobacman JK., Free PMC Article | 02/1/2010 |
| These results clearly indicate that NIK is involved in the constitutive activation of the alternative pathway and controls cell proliferation in pancreatic cancer cells. | NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells.
Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J. | 01/21/2010 |
| Report suppression of hepatitis B virus-derived human hepatocellular carcinoma by NF-kappaB-inducing kinase-specific siRNA using liver-targeting liposomes. | Suppression of hepatitis B virus-derived human hepatocellular carcinoma by NF-kappaB-inducing kinase-specific siRNA using liver-targeting liposomes.
Cho HA, Park IS, Kim TW, Oh YK, Yang KS, Kim JS. | 01/21/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients.
Bowes JD, Potter C, Gibbons LJ, Hyrich K, Plant D, Morgan AW, Wilson AG, Isaacs JD, Worthington J, Barton A, BRAGGSS. | 03/25/2009 |
| Translocation of NF-kappa B to the nucleus in prostatic cancer might be due to overexpression of several components of the NIK pathway. | TNF/IL-1/NIK/NF-kappa B transduction pathway: a comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma).
Nuñez C, Cansino JR, Bethencourt F, Pérez-Utrilla M, Fraile B, Martínez-Onsurbe P, Olmedilla G, Paniagua R, Royuela M. | 01/21/2010 |
| NIK functions downstream of Cot to mediate p65 phosphorylation. | NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.
Wittwer T, Schmitz ML. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHigh-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.
Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario JL, Velloso ML, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna AR, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar MD, Blanco FJ, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino JJ, Gonzalez A. | 05/11/2008 |
| NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1 | NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.
Lee EJ, Seo SR, Um JW, Park J, Oh Y, Chung KC. | 01/21/2010 |
| This study demonstrates that NF-kappaB-inducing kinase (NIK) is a critical target of the endogenous ROS in NF-kappaB pathways. | The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells.
Wang Y, Huang X, Cang H, Gao F, Yamamoto T, Osaki T, Yi J. | 01/21/2010 |
| induction of noncanonical NF-kappaB signaling may involve the rescue of NIK from TRAF3-mediated negative regulation | Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.
Liao G, Zhang M, Harhaj EW, Sun SC. | 01/21/2010 |
| subcellular distribution of NIK to different compartments might be a means of regulating the function of this kinase | Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK.
Birbach A, Bailey ST, Ghosh S, Schmid JA. | 01/21/2010 |
| Results for the first time place NF-kappa B-inducing kinase (NIK), previously shown to function in TNF signaling, within the interferon signal transduction pathway | Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival.
Yang CH, Murti A, Pfeffer LM., Free PMC Article | 01/21/2010 |