| The structural consequences of two hTRbeta mutants, residing in the flexible N-terminal portion of the ligand binding domain (LBD), were investigated. These mutants exhibit modestly reduced hormone binding with impaired release of corepressor. | Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.
Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. | 01/21/2010 |
| demonstrated that TR isoforms THRA2 and THRB1 and NCoAs are autoregulated transcription factors with tissue specificity. | Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone.
Sadow PM, Chassande O, Koo EK, Gauthier K, Samarut J, Xu J, O'Malley BW, Weiss RE. | 01/21/2010 |
| Increased TR expression in the hypertrophied heart is associated with an improvement in contractile function and increased SERCA expression. | Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy.
Belke DD, Gloss B, Swanson EA, Dillmann WH. | 01/21/2010 |
| Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis. | Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis.
Ying H, Suzuki H, Zhao L, Willingham MC, Meltzer P, Cheng SY. | 01/21/2010 |