| these results indicate that miR455 is involved in gastric cancer progression by directly targeting IGF1R and may serve as a novel therapeutic target for the treatment of gastric cancer. | MicroRNA‑455 is downregulated in gastric cancer and inhibits cell proliferation, migration and invasion via targeting insulin‑like growth factor 1 receptor.
Zhang S, Yin WL, Zhang X, Zhang XY. | 04/28/2018 |
| Low expression of miR455 is associated with gastric cancer. | miR-455 inhibits cell proliferation and migration via negative regulation of EGFR in human gastric cancer.
Ning T, Peng Z, Li S, Qu Y, Zhang H, Duan J, Wang X, Yang H, Liu R, Deng T, Bai M, Wang Y, Si Y, Zhang L, Wang X, Ge S, Zhou L, Ying G, Ba Y. | 04/7/2018 |
| the present study confirmed the tumor suppressor function of miR-455 in melanoma, and demonstrated that miR-455 suppressed proliferation and invasion through directly targeting IGF-1R. | Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma.
Wang H, Yu L, Shan X. | 03/10/2018 |
| An increase in miR-455-3p expression found in AD patients and Abeta pathologies unveiled its biomarker characteristics and a precise role in AD pathogenesis. | MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer's disease.
Kumar S, Vijayan M, Reddy PH., Free PMC Article | 01/27/2018 |
| Taken together, our results for the first time suggested that miR-455-3p was downregulated in NSCLC and was correlated with the poor prognosis of NSCLC patients. Also, miR-455-3p functions as tumor suppressor by directly targeting HOXB5 in NSCLC progression and may be used as a potential target for NSCLC treatment. | miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.
Gao X, Zhao H, Diao C, Wang X, Xie Y, Liu Y, Han J, Zhang M. | 12/30/2017 |
| miR-455 inhibits breast cancer cell proliferation through targeting CDK14 | miR-455 inhibits breast cancer cell proliferation through targeting CDK14.
Wang B, Zou A, Ma L, Chen X, Wang L, Zeng X, Tan T. | 12/9/2017 |
| The miR-139-5p, 455-5p and let-7b signature, in particular, may represent an important therapeutic target in KIT/PDGFRA WT-SDH deficient GIST, usually characterized by IGF1R overexpression. | Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors.
Pantaleo MA, Ravegnini G, Astolfi A, Simeon V, Nannini M, Saponara M, Urbini M, Gatto L, Indio V, Sammarini G, Santini D, Ferracin M, Negrini M, Hrelia P, Biasco G, Angelini S. | 10/14/2017 |
| High miR455-3p expression is associated with triple negative breast cancer. | MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24.
Li Z, Meng Q, Pan A, Wu X, Cui J, Wang Y, Li L., Free PMC Article | 10/14/2017 |
| The findings suggest that miR-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 acetylation. | MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.
Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z, Liao W. | 10/7/2017 |
| miR-455 inhibited cell proliferation while inducing cell apoptosis by targeting HDAC2 in colorectal cancer cells. | MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer.
Mao QD, Zhang W, Zhao K, Cao B, Yuan H, Wei LZ, Song MQ, Liu XS., Free PMC Article | 09/30/2017 |
| Findings suggest that miR-455-3p functions as a tumor suppressor by directly targeting eIF4E in prostate carcinogenesis. | MicroRNA-455-3p functions as a tumor suppressor by targeting eIF4E in prostate cancer.
Zhao Y, Yan M, Yun Y, Zhang J, Zhang R, Li Y, Wu X, Liu Q, Miao W, Jiang H. | 07/1/2017 |
| In conclusion, we reveal that miR-455-5p expression is regulated by the TGF-beta-dependent pathway, which subsequently leads to UBE2B down-regulation and contributes to oral cancer tumourigenesis. | Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Cheng CM, Shiah SG, Huang CC, Hsiao JR, Chang JY. | 05/6/2017 |
| The overexpression of miR-455-3p markedly elevated the levels of Bax, pro-caspase 3, and active caspase-3, but significantly reduced the levels of Bcl-2 in HCT116 cells, demonstrating that overexpression of miR-455-3p induced cell apoptosis. Thus miR-455-3p functions as a tumor suppressor in HCT116 cells by inhibition of cell proliferation and induction of apoptosis. | MicroRNA-455-3p Inhibits Tumor Cell Proliferation and Induces Apoptosis in HCT116 Human Colon Cancer Cells.
Zheng J, Lin Z, Zhang L, Chen H., Free PMC Article | 04/15/2017 |
| Runx2 is a direct downstream target of miR-455 in hepatocellular carcinoma. | MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2.
Qin L, Zhang Y, Lin J, Shentu Y, Xie X. | 03/25/2017 |
| miR-455 directly binds to 3'UTR of ZEB1 and suppresses the endogenous level of ZEB1 protein expression. overexpression of ZEB1 reverses miR-455-suppressed malignant phenotype of NSCLC cells. upregulation of ZEB1 expression is inversely associated with miR-455 expression in NSCLC tissues. Taken together, miR-455 as an anti-oncogene in non-small cell lung cancer through up-regulation of ZEB1 | MicroRNA-455 suppresses non-small cell lung cancer through targeting ZEB1.
Li YJ, Ping C, Tang J, Zhang W. | 02/25/2017 |
| miR-455-5p was reduced significantly in gastric cancer cells and tissues . MiR-455-5p acts as a tumor suppressor in gastric cancer. | MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18.
Liu J, Zhang J, Li Y, Wang L, Sui B, Dai D. | 02/18/2017 |
| Data suggest that three microRNAs (miR-191-3p, miR-455-3p, and miR-1281) are up-regulated in plasma of patients with abdominal aortic aneurysms as compared to control subjects; thus, these microRNAs are potential plasma biomarkers. | Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm.
Zhang W, Shang T, Huang C, Yu T, Liu C, Qiao T, Huang D, Liu Z, Liu C. | 07/2/2016 |
| MiR455 represses a hypoxia response that might otherwise prevent cytotrophoblasts from syncytiotrophoblast differentiation. | miR455 is linked to hypoxia signaling and is deregulated in preeclampsia.
Lalevée S, Lapaire O, Bühler M., Free PMC Article | 09/12/2015 |
| our study demonstrated that miR-455-RAF1 may represent a new potential therapeutic target for colorectal carcinoma treatment. | MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase.
Chai J, Wang S, Han D, Dong W, Xie C, Guo H. | 06/20/2015 |
| Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. | Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
Shoshan E, Mobley AK, Braeuer RR, Kamiya T, Huang L, Vasquez ME, Salameh A, Lee HJ, Kim SJ, Ivan C, Velazquez-Torres G, Nip KM, Zhu K, Brooks D, Jones SJ, Birol I, Mosqueda M, Wen YY, Eterovic AK, Sood AK, Hwu P, Gershenwald JE, Robertson AG, Calin GA, Markel G, Fidler IJ, Bar-Eli M., Free PMC Article | 05/2/2015 |
| MiR-455 was underexpressed in medullary thyroid carcinoma. | Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma.
Hudson J, Duncavage E, Tamburrino A, Salerno P, Xi L, Raffeld M, Moley J, Chernock RD., Free PMC Article | 09/14/2013 |