| DEC1 is induced by the p53 family and DNA damage in a p53-dependent manner. p53 family proteins bind to, and activate, the promoter of the DEC1 gene. | DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.
Qian Y, Zhang J, Yan B, Chen X., Free PMC Article | 01/21/2010 |
| MLH1 is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. | Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2.
Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, Yoshiga K, Poellinger L, Hiyama E, Nishiyama M. | 01/21/2010 |
| DEC1, along with DEC2, plays a role in the finer regulation and robustness of the molecular clock CLOCK/BMAL1 | DEC1 modulates the circadian phase of clock gene expression.
Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, Kohno N, Kato Y., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesSystematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.
Utge SJ, Soronen P, Loukola A, Kronholm E, Ollila HM, Pirkola S, Porkka-Heiskanen T, Partonen T, Paunio T. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.
Soria V, Martínez-Amorós E, Escaramís G, Valero J, Pérez-Egea R, García C, Gutiérrez-Zotes A, Puigdemont D, Bayés M, Crespo JM, Martorell L, Vilella E, Labad A, Vallejo J, Pérez V, Menchón JM, Estivill X, Gratacòs M, Urretavizcaya M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. PER2 variantion is associated with depression vulnerability.
Lavebratt C, Sjöholm LK, Partonen T, Schalling M, Forsell Y. | 09/20/2009 |
| differentiated embryo-chondrocyte expressed gene 1 downregulates hypoxia-inducible factor 1alpha at both mRNA and protein levels at hypoxia in lung adenocarcinoma cells | Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1alpha, is another marker of lung tumor hypoxia.
Zhang L, Li QQ. | 01/21/2010 |
| link between HIF-1 and STAT1 reveals a previously unknown role of STRA13 in hypoxia and carcinogenesis | Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13.
Ivanov SV, Salnikow K, Ivanova AV, Bai L, Lerman MI. | 01/21/2010 |
| A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with bipolar disorder | Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.
Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C, Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C., Free PMC Articles: PMC2574897, PMC2574897 | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.
Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C, Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C., Free PMC Articles: PMC2574897, PMC2574897 | 04/3/2008 |
| Findings suggest that the basic region of DEC1 participates in the transcriptional regulation through a protein-protein interaction with BMAL1 and DNA binding to the E-box. | Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.
Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y. | 01/21/2010 |
| hypoxia-induced gene in pancreatic cancer cell lines | Identification of genes differentially induced by hypoxia in pancreatic cancer cells.
Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O. | 01/21/2010 |
| DEC1-mediated anti-apoptosis is achieved by blocking apoptotic pathways initiated via the mitochondria. The results functionally distinguish DEC1 from other bHLH proteins and directly link this factor to oncogenesis. | Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation.
Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B., Free PMC Article | 01/21/2010 |
| These findings suggest that Dec1 modulates osteogenic differentiation of mesenchymal stem cells by inducing the expression of several, but not all, bone-related genes. | Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells.
Iwata T, Kawamoto T, Sasabe E, Miyazaki K, Fujimoto K, Noshiro M, Kurihara H, Kato Y. | 01/21/2010 |
| DEC1 and DEC2 may play a crucial role in the adaptation to hypoxia | Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.
Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y. | 01/21/2010 |
| DEC1 is the first transcription factor that can promote both chondrogenic differentiation and terminal differentiation | Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages.
Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y. | 01/21/2010 |
| DEC1-mediated repression on the expression of DEC2 provides an important mechanism that these transcription factors regulate the cellular function of members within the same class | DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.
Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B. | 01/21/2010 |
| Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. | Dec1 and Dec2 are regulators of the mammalian molecular clock.
Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K. | 01/21/2010 |