| Mutating the four extracellular cysteines reveals their differing roles in receptor trafficking, ligand binding, and signaling. | Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling.
Ai LS, Liao F. | 01/21/2010 |
| association between expression level of CCR6 in primary CRC and synchronous liver metastases suggests that CCR6 and its ligand may be involved in the metastatic spread to the liver | Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer.
Ghadjar P, Coupland SE, Na IK, Noutsias M, Letsch A, Stroux A, Bauer S, Buhr HJ, Thiel E, Scheibenbogen C, Keilholz U. | 01/21/2010 |
| Up-regulation on distinct subpopulations of antigen-activated CD4+ T lymphocytes | Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes.
Ebert LM, McColl SR. | 01/21/2010 |
| CCR6 has multiple domains involved in ligand binding and receptor signaling | Molecular characterization of CCR6: involvement of multiple domains in ligand binding and receptor signaling.
Ai LS, Lee SF, Chen SS, Liao F. | 01/21/2010 |
| CCR1, CCR6, and CXCR6 are preferentially expressed by the low cytokine-producing CD8 and CD4(-)CD8(-) subsets of natural killer T-cells. | Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.
Kim CH, Johnston B, Butcher EC. | 01/21/2010 |
| CCR6 mediated signals result in increased IEC migration and proliferation suggesting an important role in intestinal homeostasis and intestinal inflammation by mediating chemotaxis of IEC but also in mediating migration of CRC cells. | Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells.
Brand S, Olszak T, Beigel F, Diebold J, Otte JM, Eichhorst ST, Göke B, Dambacher J. | 01/21/2010 |
| CCR6-expressing CD8+ T cells have the ability to migrate in response to CCL20, may migrate to tissues such as colon, and are involved in mucosal immunity. | Functional expression of chemokine receptor CCR6 on human effector memory CD8+ T cells.
Kondo T, Takata H, Takiguchi M. | 01/21/2010 |
| CCR6 on polarized intestinal epithelial cells, alter specialized intestinal epithelial cell functions, including electrogenic ion secretion and possibly epithelial cell adhesion and migration | Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells.
Yang CC, Ogawa H, Dwinell MB, McCole DF, Eckmann L, Kagnoff MF. | 01/21/2010 |
| CCR6 preferentially attracts memory B cells and becomes an efficacious B-cell receptor following cellular activation, acquiring an enhanced function due to changes in the responsiveness of downstream signaling pathways. | Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding.
Liao F, Shirakawa AK, Foley JF, Rabin RL, Farber JM. | 01/21/2010 |
| characterized the expression of CCR6 on B cells and B-cell non-Hodgkin's lymphomas | CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomas.
Rodig SJ, Jones D, Shahsafaei A, Dorfman DM. | 01/21/2010 |
| CXCR4 expression in colorectal liver metastases suggests it is a predictive factor. CCL20 and receptor CCR6 expression in hepatocellular carcinomas indicates a role of a CCL20/CCR6 ligand-receptor pair in liver carcinogenesis and progression. | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases.
Rubie C, Frick VO, Wagner M, Weber C, Kruse B, Kempf K, König J, Rau B, Schilling M., Free PMC Article | 01/21/2010 |
| Coincident expression of CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis may contribute to their accumulation in nonlymphoid organs such as skin and bone | Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis.
Fleming MD, Pinkus JL, Fournier MV, Alexander SW, Tam C, Loda M, Sallan SE, Nichols KE, Carpentieri DF, Pinkus GS, Rollins BJ. | 01/21/2010 |
| Our results add new insight to the important role of the CCL20/CCR6, RANKL system in the bone tissue of rheumatoid arthritis. | CCL20 chemokine induces both osteoblast proliferation and osteoclast differentiation: Increased levels of CCL20 are expressed in subchondral bone tissue of rheumatoid arthritis patients.
Lisignoli G, Piacentini A, Cristino S, Grassi F, Cavallo C, Cattini L, Tonnarelli B, Manferdini C, Facchini A. | 01/21/2010 |
| CCR6, appears to have an important role in the selective recruitment of T cells, in the context of periodontal inflammation. | Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue.
Hosokawa Y, Nakanishi T, Yamaguchi D, Takahashi K, Yumoto H, Ozaki K, Matsuo T., Free PMC Article | 01/21/2010 |
| MIP-3alpha/CCL20 has a role in amplification of the immune response during renal allograft rejection by attraction of CCR6+ inflammatory cells, which may include DC, to the site of inflammation | MIP-3alpha/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection.
Woltman AM, de Fijter JW, van der Kooij SW, Jie KE, Massacrier C, Caux C, Daha MR, van Kooten C. | 01/21/2010 |