| Both endogenous and heterologously expressed TRPM7 was found in tubulovesicular structures that were translocated to the region of the plasma membrane on induction of shear stress. | Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow.
Oancea E, Wolfe JT, Clapham DE. | 01/21/2010 |
| the channel may serve as a regulated transport mechanism for these ions that could affect cell adhesion, cell growth and proliferation, and even cell death under pathological stress such as anoxia--{REVIEW} | The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7.
Penner R, Fleig A., Free PMC Article | 01/21/2010 |
| TRPM7 activity is up- and down-regulated through its endogenous kinase in a cAMP- and protein kinase A-dependent manner | Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.
Takezawa R, Schmitz C, Demeuse P, Scharenberg AM, Penner R, Fleig A., Free PMC Article | 01/21/2010 |
| A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. | A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders.
Hermosura MC, Nayakanti H, Dorovkov MV, Calderon FR, Ryazanov AG, Haymer DS, Garruto RM., Free PMC Article | 01/21/2010 |
| under physiological ionic conditions, TRPM7 currents are activated rather than inhibited by PLC-activating receptor agonists | Activation of TRPM7 channels by phospholipase C-coupled receptor agonists.
Langeslag M, Clark K, Moolenaar WH, van Leeuwen FN, Jalink K. | 01/21/2010 |
| TRPM7-deficient cells become Mg(2+) deficient & are not viable.TRPM7 is characterized functionally as constitutively active ion channel permeable for variety of cations including Ca & Mg & regulated by intracellular Mg &/or Mg-nucleotide complexes[review] | Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.
Chubanov V, Gudermann T, Schlingmann KP. | 01/21/2010 |
| heterologous expression of TRPM6 but not the mutant TRPM6(S141L) produces functional channels with divalent cation permeability profile and pH sensitivity distinctive from those of TRPM7 channels and TRPM6/7 complexes | Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.
Li M, Jiang J, Yue L., Free PMC Article | 01/21/2010 |
| We thus conclude that the TRPM7 channel can be directly activated by mechano-stress in a manner independent of exocytosis-mediated incorporation of this channel protein into the plasma membrane. | Direct mechano-stress sensitivity of TRPM7 channel.
Numata T, Shimizu T, Okada Y. | 01/21/2010 |