| during development, endothelial Acvrl1 plays an essential role to regulate endothelial cell proliferation and arterial identity during angiogenesis, whilst in adult life endothelial Acvrl1 is required to maintain vascular integrity. | Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.
Tual-Chalot S, Mahmoud M, Allinson KR, Redgrave RE, Zhai Z, Oh SP, Fruttiger M, Arthur HM., Free PMC Article | 08/22/2015 |
| Results show that ALK5 and ALK1 play antagonistic roles in TGF-beta-induced podosome formation in aortic endothelial cells. | ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
Curado F, Spuul P, Egaña I, Rottiers P, Daubon T, Veillat V, Duhamel P, Leclercq A, Gontier E, Génot E., Free PMC Article | 01/18/2015 |
| ALK1 modulates obstruction-induced renal fibrosis by increased extracellular matrix synthesis in myofibroblasts, but without differences in myofibroblast number. | Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy.
Muñoz-Félix JM, López-Novoa JM, Martínez-Salgado C. | 10/4/2014 |
| the mechanisms responsible for the angiogenic imbalance and the response to anti-VEGF therapy differ between Eng and Alk1 heterozygous mice and raise the need for systemic monitoring of anti-angiogenic therapy effects in HHT patients. | Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment.
Ardelean DS, Jerkic M, Yin M, Peter M, Ngan B, Kerbel RS, Foster FS, Letarte M. | 08/23/2014 |
| Deletion of Alk1 in endothelial cells in adult mice leads to an increased local endothelial cell proliferation during brain angiogenesis | De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation.
Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H., Free PMC Article | 04/26/2014 |
| FGF2 inhibited BMP9-induced osteogenic differentiation by blocking BMP9-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2 in mesenchymal stem cells. | Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2.
Song T, Wang W, Xu J, Zhao D, Dong Q, Li L, Yang X, Duan X, Liang Y, Xiao Y, Wang J, He J, Tang M, Wang J, Luo J. | 02/15/2014 |
| ALK-1 signals inhibit lymphatic vessel (LV) formation, and LVs were enlarged in multiple organs in Alk1-depleted mice. | Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression.
Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI, Maruyama K, Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, Miyazono K, Watabe T., Free PMC Article | 01/25/2014 |
| Endoglin contributes to both shear induced collateral artery growth and to ischaemia induced angiogenesis, whereas ALK1 is only involved in ischaemia induced angiogenesis. | Shear induced collateral artery growth modulated by endoglin but not by ALK1.
Seghers L, de Vries MR, Pardali E, Hoefer IE, Hierck BP, ten Dijke P, Goumans MJ, Quax PH., Free PMC Article | 03/30/2013 |
| Reduction of mural cell coverage in response to vascular endothelial growth factor stimulation is a potential mechanism for the impairment of vessel wall integrity in Alk1-deficient mouse brain. | Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain.
Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL., Free PMC Article | 03/16/2013 |
| ALK1 is upregulated in endothelial cells during vascular injury by a synergistic cooperative mechanism between KLF6 and specificity protein 1. | Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene.
Garrido-Martín EM, Blanco FJ, Roquè M, Novensà L, Tarocchi M, Lang UE, Suzuki T, Friedman SL, Botella LM, Bernabéu C., Free PMC Article | 03/2/2013 |
| Deletion of Eng induces more severe cerebrovascular dysplasia per copy than that of Alk1 upon VEGF stimulation. | Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.
Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H., Free PMC Article | 12/8/2012 |
| PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1 | Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.
Benzinou M, Clermont FF, Letteboer TG, Kim JH, Espejel S, Harradine KA, Arbelaez J, Luu MT, Roy R, Quigley D, Higgins MN, Zaid M, Aouizerat BE, van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Plauchu H, Hughes CC, Westermann CJ, Akhurst RJ., Free PMC Article | 07/28/2012 |
| The results uncovered a direct link between ALK1 and Notch signaling during vascular morphogenesis that may be relevant to the pathogenesis of hereditary hemorrhagic telangiectasia vascular lesions. | ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.
Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A., Free PMC Article | 05/19/2012 |
| Increased pulmonary vascular remodelling in Alk1(+/-) mice leads to signs of pulmonary hypertension and is associated with eNOS-dependent ROS production, which is preventable by anti-oxidant treatment. | Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress.
Jerkic M, Kabir MG, Davies A, Yu LX, McIntyre BA, Husain NW, Enomoto M, Sotov V, Husain M, Henkelman M, Belik J, Letarte M. | 03/3/2012 |
| Kidneys of ALK(+/+) and ALK1(+/-) mice were irradiated with 14 Gy. ALK1(+/-) mice develop a delayed normal tissue response by modulating the inflammatory response and growth factor expression after irradiation. | ALK1 heterozygosity delays development of late normal tissue damage in the irradiated mouse kidney.
Scharpfenecker M, Floot B, Korlaar R, Russell NS, Stewart FA. | 12/10/2011 |
| ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth | ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.
Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R. | 11/13/2010 |
| Results strongly suggest that ALK1 and ALK2 may play an important role in mediating BMP9-induced osteogenic differentiation. | TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells.
Luo J, Tang M, Huang J, He BC, Gao JL, Chen L, Zuo GW, Zhang W, Luo Q, Shi Q, Zhang BQ, Bi Y, Luo X, Jiang W, Su Y, Shen J, Kim SH, Huang E, Gao Y, Zhou JZ, Yang K, Luu HH, Pan X, Haydon RC, Deng ZL, He TC., Free PMC Article | 10/4/2010 |
| a novel aspect of ALK1 signaling in regulating lymphatic development and suggests that targeting ALK1 pathway might provide additional control of lymphangiogenesis in human diseases. | ALK1 signaling regulates early postnatal lymphatic vessel development.
Niessen K, Zhang G, Ridgway JB, Chen H, Yan M., Free PMC Article | 03/29/2010 |
| Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. | Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.
Cunha SI, Pardali E, Thorikay M, Anderberg C, Hawinkels L, Goumans MJ, Seehra J, Heldin CH, ten Dijke P, Pietras K., Free PMC Article | 02/22/2010 |
| age-related shift in ALK1/ALK5 ratio in murine cartilage and a strong correlation between ALK1 and MMP-13 expression in human cartilage | Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.
Blaney Davidson EN, Remst DF, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM. | 01/21/2010 |
| Eng was more widely expressed than Acvrl1 in lungs. Association of ACVRL1 mutations with pulmonary artery hypertension underlines importance of ACVRL1 expression in distal arteries affected in this disorder. | Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH.
Mahmoud M, Borthwick GM, Hislop AA, Arthur HM. | 01/21/2010 |
| Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. | Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.
Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY., Free PMC Article | 01/21/2010 |
| neither ALK5 nor TGFBR2 is required for ALK1 signaling pertinent to the pathogenesis of HHT and suggest that HHT might not be a TGF-beta subfamily disease. | ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2.
Park SO, Lee YJ, Seki T, Hong KH, Fliess N, Jiang Z, Park A, Wu X, Kaartinen V, Roman BL, Oh SP., Free PMC Article | 01/21/2010 |
| Results from this study provide valuable information regarding the role of ALK1 in the development of placental vasculature as well as insights into the pathogenesis of HHT. | Activin receptor-like kinase 1 is essential for placental vascular development in mice.
Hong KH, Seki T, Oh SP. | 01/21/2010 |
| Using a series of transgenic constructs with various Alk1 genomic fragments joined to a reporter, it seems a 9.2-kb genomic fragment including the 2.7-kb promoter region & the whole intron 2 is sufficient for arterial endothelium-specific expression. | Isolation of a regulatory region of activin receptor-like kinase 1 gene sufficient for arterial endothelium-specific expression.
Seki T, Hong KH, Yun J, Kim SJ, Oh SP. | 01/21/2010 |