| Neurog1/2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium. | Neurog1 and Neurog2 coordinately regulate development of the olfactory system.
Shaker T, Dennis D, Kurrasch DM, Schuurmans C., Free PMC Article | 02/16/2013 |
| Gene expression analyses revealed that Ngn2-induced in vitro differentiation partially resembled neurogenesis in vivo, as it included specific activation of Ngn2 target genes and interaction partners | Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons.
Thoma EC, Wischmeyer E, Offen N, Maurus K, Sirén AL, Schartl M, Wagner TU., Free PMC Article | 12/22/2012 |
| Neurogenin 1 expression in mouse embryonic stem (ES) cells promotes neural differentiation and inhibits proliferation, thus establishing an approach to graft ES cells safely into the spinal cord. | Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors.
Lunn JS, Pacut C, Stern E, Sakowski SA, Velkey JM, O'Shea S, Feldman EL., Free PMC Article | 11/24/2012 |
| Loss of microprocessor activity results not only in an increase Ngn2 protein but also extended expression of Neurog2 into later stages of the neurogenic lineage. | Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.
Knuckles P, Vogt MA, Lugert S, Milo M, Chong MM, Hautbergue GM, Wilson SA, Littman DR, Taylor V. | 09/8/2012 |
| It was shown that, in the cerebellar primordium, neurogenin 2 is expressed by cycling progenitors fated to become Purkinje cells. During cerebellar development, neurogenin 2 is expressed in G1 phase by progenitors poised to exit the cell cycle. | Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development.
Florio M, Leto K, Muzio L, Tinterri A, Badaloni A, Croci L, Zordan P, Barili V, Albieri I, Guillemot F, Rossi F, Consalez GG., Free PMC Article | 08/18/2012 |
| temporal regulation of neurogenin 2 heterodimerization by GSK3 is a central component of the neuronal differentiation "clock" that coordinates the timing and tempo of neocortical neurogenesis in mouse | GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex.
Li S, Mattar P, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Dixit R, Kurrasch DM, Ma YC, Chan JA, Wallace V, Dilworth FJ, Brand M, Schuurmans C., Free PMC Article | 08/11/2012 |
| the formation of cranial ganglia along the anterior-posterior axis is dependent on the dynamic spatiotemporal activities of Neurog1 and/or Neurog2 in both neural crest and epibranchial placode. | Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis.
Takano-Maruyama M, Chen Y, Gaufo GO., Free PMC Article | 07/21/2012 |
| Data show that Bmp7 regulates Ngn2 steady-state transcript levels in the E14.5 cortex. | Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.
Segklia A, Seuntjens E, Elkouris M, Tsalavos S, Stappers E, Mitsiadis TA, Huylebroeck D, Remboutsika E, Graf D., Free PMC Article | 06/30/2012 |
| Ngn2 is required for the coordinated specification of cardinal features defining the phenotype of cortical pyramidal neurons, including their migration properties, dendritic morphology and axonal projection. | Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum.
Hand R, Polleux F., Free PMC Article | 06/23/2012 |
| NeuroD promoter is substantially more sensitive to the phosphorylation status of Ngn2 than the Delta promoter, and that this can be attributed to differences in the ease of promoter activation. | Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation.
Hindley C, Ali F, McDowell G, Cheng K, Jones A, Guillemot F, Philpott A., Free PMC Article | 06/9/2012 |
| multi-site cdk-dependent phosphorylation of Ngn2 interprets cdk levels to control neuronal differentiation in response to cell cycle lengthening during development | Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis.
Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A., Free PMC Article | 11/26/2011 |
| Results indicate that LMO4 promotes the acquisition of cortical neuronal identities by forming a complex with NGN2 and subsequently activating NGN2-dependent gene expression. | LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.
Asprer JS, Lee B, Wu CS, Vadakkan T, Dickinson ME, Lu HC, Lee SK., Free PMC Article | 08/27/2011 |
| all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the olfactory bulb | Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells.
Winpenny E, Lebel-Potter M, Fernandez ME, Brill MS, Götz M, Guillemot F, Raineteau O., Free PMC Article | 07/23/2011 |
| Neurog2 controls the leading edge of neurogenesis in the mouse retina. | Neurog2 controls the leading edge of neurogenesis in the mammalian retina.
Hufnagel RB, Le TT, Riesenberg AL, Brown NL., Free PMC Article | 05/31/2010 |
| localization of neurogenin2, NeuroD and Mash 1 in the embryonic forebrain is highly similar to the situation described in Xenopus and zebrafish, suggesting a temporally and spatially defined control of neurogenesis during development | Phylotypic expression of the bHLH genes Neurogenin2, Neurod, and Mash1 in the mouse embryonic forebrain.
Osório J, Mueller T, Rétaux S, Vernier P, Wullimann MF. | 04/12/2010 |
| Data show that Neurog2 expression is directly regulated by the PTF1-Rbpj complex, identifying Neurog2 as the first neural target of Ptf1a and revealing a bHLH cascade in the specification of GABAergic neurons in the dorsal spinal cord and cerebellum. | Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.
Henke RM, Savage TK, Meredith DM, Glasgow SM, Hori K, Dumas J, MacDonald RJ, Johnson JE., Free PMC Article | 01/21/2010 |
| Ngn2 and Mash1 are differentially sensitive to negative regulation by gliogenic factors or a gliogenic substrate | Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues.
Geoffroy CG, Critchley JA, Castro DS, Ramelli S, Barraclough C, Descombes P, Guillemot F, Raineteau O. | 01/21/2010 |
| critical role of for Ngn2 and NeuroD1 in controlling neuronal commitment and hippocampal granule neuroblast formation, both during embryonic development and in post-natal hippocampal granule neurogenesis | Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis.
Roybon L, Hjalt T, Stott S, Guillemot F, Li JY, Brundin P., Free PMC Article | 01/21/2010 |
| novel Ascl1 containing DNA binding complexes interact with specific E-box sites within the Dll3-promoter in vitro. These complexes include Ascl1/Ascl1 homodimers and Ascl1/Neurog2 heterodimers. | Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube.
Henke RM, Meredith DM, Borromeo MD, Savage TK, Johnson JE., Free PMC Article | 01/21/2010 |
| Taken together, our data illustrate that Ngn2, neuroD and Tbr transcription factors are involved in postnatal neurogenesis in the olfactory bulb. | Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis.
Roybon L, Deierborg T, Brundin P, Li JY. | 01/21/2010 |
| Results suggest that Notch signaling in nascent daughter cells suppresses a Ngn2-Tbr2 cascade. | Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells.
Ochiai W, Nakatani S, Takahara T, Kainuma M, Masaoka M, Minobe S, Namihira M, Nakashima K, Sakakibara A, Ogawa M, Miyata T. | 01/21/2010 |
| Combinatorial signalling controls Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis. | Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis.
Ribes V, Stutzmann F, Bianchetti L, Guillemot F, Dollé P, Le Roux I. | 01/21/2010 |
| results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration | Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F. | 01/21/2010 |
| Data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis. | Neurogenin 2 has an essential role in development of the dentate gyrus.
Galichet C, Guillemot F, Parras CM. | 01/21/2010 |
| Ngn1, Ngn2 and Mash1 are expressed at relevant stages of cerebellar neurogenesis in the prospective cerebellar nuclei and in the ventricular zone | Comparative analysis of proneural gene expression in the embryonic cerebellum.
Zordan P, Croci L, Hawkes R, Consalez GG. | 01/21/2010 |