| Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. | Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
Yang JQ, Kalim KW, Li Y, Duan X, Nguyen P, Khurana Hershey GK, Kroner J, Ruff B, Zhang L, Salomonis N, Rochman M, Wen T, Zheng Y, Guo F., Free PMC Article | 09/26/2020 |
| Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. | Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.
Mammoto T, Torisawa YS, Muyleart M, Hendee K, Anugwom C, Gutterman D, Mammoto A., Free PMC Article | 09/5/2020 |
| Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development. | Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.
Zhang M, Wang X, Guo F, Jia Q, Liu N, Chen Y, Yan Y, Huang M, Tang H, Deng Y, Huang S, Zhou Z, Zhang L, Zhang L., Free PMC Article | 08/22/2020 |
| The results indicate that SLIT2 inhibits osteoclastogenesis and the resultant bone resorption by decreasing Cdc42 activity, suggesting that this is a potential therapeutic target in metabolic bone diseases related to high bone turnover states. | SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity.
Park SJ, Lee JY, Lee SH, Koh JM, Kim BJ. | 06/20/2020 |
| Knockdown of Cdc42, a Rho family protein, caused mislocalization of neonatal dentate granule cells, although the effects were moderate compared to Rac1 and 3. Despite the ectopic localization, Rac3- or Cdc42-disrupted mispositioned cells expressed Prox1. | Rho family GTPases, Rac and Cdc42, control the localization of neonatal dentate granule cells during brain development.
Ito H, Morishita R, Mizuno M, Tabata H, Nagata KI. | 06/6/2020 |
| activation of Cdc42 by endothelin signaling is important for cardiac neural crest cell migration in the outflow tract but this pathway is not involved in mandibular or pharyngeal arch artery patterning. | Cdc42 activation by endothelin regulates neural crest cell migration in the cardiac outflow tract.
Fritz KR, Zhang Y, Ruest LB. | 05/9/2020 |
| Here, the authors show that angiogenic collective endothelial cell migration is regulated by non-canonical Wnt signaling. They identify that Wnt5a specifically activates Cdc42 at cell junctions downstream of ROR2 to reinforce coupling between adherens junctions and the actin cytoskeleton. | Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration.
Carvalho JR, Fortunato IC, Fonseca CG, Pezzarossa A, Barbacena P, Dominguez-Cejudo MA, Vasconcelos FF, Santos NC, Carvalho FA, Franco CA., Free PMC Article | 02/29/2020 |
| These results showed that loss of Cdc42 caused a defect of intramembranous ossification in cranial bone tissues which is related to decreased expressions of cranial suture morphogenesis genes, including Indian hedgehog and bone morphogenetic proteins. | Cdc42 regulates cranial suture morphogenesis and ossification.
Aizawa R, Yamada A, Seki T, Tanaka J, Nagahama R, Ikehata M, Kato T, Sakashita A, Ogata H, Chikazu D, Maki K, Mishima K, Yamamoto M, Kamijo R. | 02/8/2020 |
| endothelial-specific deletion of Cdc42 elicits CCM-like cerebrovascular malformations and that CDC42 is engaged in the cerebral cavernous malformation signaling network to restrain the MEKK3-MEK5-ERK5-KLF2/4 pathway. | CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.
Castro M, Laviña B, Ando K, Álvarez-Aznar A, Abu Taha A, Brakebusch C, Dejana E, Betsholtz C, Gaengel K. | 01/25/2020 |
| Cdc42 is apparently required for both articular cartilage degeneration and subchondral bone deterioration of osteoarthritis, thus, interventions targeting Cdc42 have potential in osteoarthritic therapy. | Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis.
Hu X, Ji X, Yang M, Fan S, Wang J, Lu M, Shi W, Mei L, Xu C, Fan X, Hussain M, Du J, Wu J, Wu X. | 10/26/2019 |
| we have shown that two isoforms of Cdc42 gene with distinct functions in neuronal polarity are differentially localized between neurites and soma of mESC-derived and mouse primary cortical neurons, at both mRNA and protein level. | Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli C, Rom A, Franke V, Imami K, Arrey G, Terne M, Woehler A, Akalin A, Ulitsky I, Chekulaeva M., Free PMC Article | 10/19/2019 |
| Data suggest that response similar to nicotine withdrawal or/and hypoxia induced by childhood chronic asthma enhances the BDNF-Cdc42/RhoA signaling pathway and activates cofilin1, leading to the remodeling of actin, causing the loss of dendritic spines and atrophy of dendrites, eventually resulting in behavioral alterations. | Chronic asthma-induced behavioral and hippocampal neuronal morphological changes are concurrent with BDNF, cofilin1 and Cdc42/RhoA alterations in immature mice.
Zhuang TT, Pan C, Chen JJ, Han F, Zhu XL, Xu H, Lu YP. | 10/5/2019 |
| CDC42 regulated the inflammatory response and the innate immune response in IBD mice | Cell division cycle protein 42 regulates the inflammatory response in mice bearing inflammatory bowel disease.
Dong LM, Chen XW, He XX, Jiang XP, Wu F. | 08/31/2019 |
| A specific small molecule inhibitor for Cdc42, and demonstrates that signaling molecules downstream of cytokines and chemokines. | Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.
Liu W, Du W, Shang X, Wang L, Evelyn C, Florian MC, A Ryan M, Rayes A, Zhao X, Setchell K, Meller J, Guo F, Nassar N, Geiger H, Pang Q, Zheng Y., Free PMC Article | 07/20/2019 |
| reduced levels of Cdc42 affected membrane trafficking from and toward the plasma membrane, highlighting a novel role for Cdc42 in membrane remodeling through the negative regulation of selected endocytic pathways. | Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.
Shitara A, Malec L, Ebrahim S, Chen D, Bleck C, Hoffman MP, Weigert R., Free PMC Article | 06/29/2019 |
| these results reveal that CDC42 controls the activation of primordial follicles in the mammalian ovary and that increasing the activity of CDC42 with specific activators might improve the efficiency of in vitro activation approaches, opening avenues for infertility treatments. | CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes.
Yan H, Zhang J, Wen J, Wang Y, Niu W, Teng Z, Zhao T, Dai Y, Zhang Y, Wang C, Qin Y, Xia G, Zhang H., Free PMC Article | 05/18/2019 |
| results identify a novel link between Cdc42 activity and the hematopoiesis-supportive function of mesenchymal stroma cells | Reduced Cell Division Control Protein 42 Activity Compromises Hematopoiesis-Supportive Function of Fanconi Anemia Mesenchymal Stromal Cells.
Xu J, Li X, Cole A, Sherman Z, Du W., Free PMC Article | 04/20/2019 |
| Cdc42 is a bona fide regulator of peripheral tolerance through suppression of Th17 aberrant differentiation/pathogenicity and promotion of regulatory T cell differentiation/stability/function involving metabolic signaling. | Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Kalim KW, Yang JQ, Li Y, Meng Y, Zheng Y, Guo F., Free PMC Article | 02/23/2019 |
| Elevated expression of miR302-367 in endothelial cells inhibits developmental angiogenesis via CDC42/CCND1 mediated signaling pathways. | Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways.
Pi J, Liu J, Zhuang T, Zhang L, Sun H, Chen X, Zhao Q, Kuang Y, Peng S, Zhou X, Yu Z, Tao T, Tomlinson B, Chan P, Tian Y, Fan H, Liu Z, Zheng X, Morrisey E, Zhang Y., Free PMC Article | 02/2/2019 |
| This study observed impaired collagen I secretion in mesenchymal stem cells lacking RhoA or Cdc42. | RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
Ge J, Burnier L, Adamopoulou M, Kwa MQ, Schaks M, Rottner K, Brakebusch C., Free PMC Article | 01/26/2019 |
| We concluded that CDC42 negatively regulates SEPT12 polymerization and is involved in terminal structure formation of sperm heads. | CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization.
Huang CY, Wang YY, Chen YL, Chen MF, Chiang HS, Kuo PL, Lin YH., Free PMC Article | 12/22/2018 |
| These results of this study suggest that Cdc42 and Rac1 synergistically function in BG during cerebellar corticogenesis. | Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis.
Sakamoto I, Ueyama T, Hayashibe M, Nakamura T, Mohri H, Kiyonari H, Shigyo M, Tohda C, Saito N. | 12/22/2018 |
| Cdc42 and RhoA act as a regulatory circuit downstream of the megakaryocytes -specific mechanoreceptor GPIb to coordinate polarized transendothelial platelet biogenesis. | A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.
Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B., Free PMC Article | 12/22/2018 |
| Cdc42 deficiency impairs endothelial cell function and regeneration after inflammatory vascular injury. | Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Lv J, Zeng J, Guo F, Li Y, Xu M, Cheng Y, Zhang L, Cai S, Chen Y, Zheng Y, Hu G., Free PMC Article | 11/10/2018 |
| MiR-7 inhibited peripheral nerve injury repair by affecting neural stem cells migration and proliferation through cdc42. | MiR-7 inhibited peripheral nerve injury repair by affecting neural stem cells migration and proliferation through cdc42.
Zhou N, Hao S, Huang Z, Wang W, Yan P, Zhou W, Zhu Q, Liu X., Free PMC Article | 10/27/2018 |