| Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-alpha. | Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-α.
Hamada N, Miyata M, Eto H, Ikeda Y, Shirasawa T, Akasaki Y, Miyauchi T, Furusho Y, Nagaki A, Aronow BJ, Tei C. | 10/1/2011 |
| Data suggest that clusterin plays a critical role to promote both exocrine and endocrine regeneration following pancreas injury, as well as for in vitro beta-cell regeneration. | Essential role of clusterin in pancreas regeneration.
Lee S, Hong SW, Min BH, Shim YJ, Lee KU, Lee IK, Bendayan M, Aronow BJ, Park IS. | 08/6/2011 |
| these results suggest that clusterin expression is increased by glucose stimulation, and SREBP-1c plays a crucial role in the metabolic regulation of clusterin. | SREBP-1c regulates glucose-stimulated hepatic clusterin expression.
Kim G, Kim GH, Oh GS, Yoon J, Kim HW, Kim MS, Kim SW. | 08/6/2011 |
| the Rarb region of Mmu14 and Stmn2, but not Cr1 or Clu or Picalm have roles in prion disease | The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
Grizenkova J, Akhtar S, Collinge J, Lloyd SE., Free PMC Article | 07/9/2011 |
| The extracellular chaperone clusterin appears in the cytosol during endoplasmic reticulum stress | Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol.
Nizard P, Tetley S, Le Dréan Y, Watrin T, Le Goff P, Wilson MR, Michel D. | 05/4/2011 |
| The chaperone clusterin mediates systemic clearance of extracellular misfolded proteins | Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
Wyatt AR, Yerbury JJ, Berghofer P, Greguric I, Katsifis A, Dobson CM, Wilson MR. | 05/4/2011 |
| The chaperone action of clusterin is important in quality control of extracellular protein folding | Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding.
Wyatt A, Yerbury J, Poon S, Dabbs R, Wilson M. | 05/4/2011 |
| The chaperone action of clusterin is ATP-independent | Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.
Poon S, Easterbrook-Smith SB, Rybchyn MS, Carver JA, Wilson MR. | 05/4/2011 |
| Clusterin has a chaperone action like that of the small heat shock proteins | Clusterin is a secreted mammalian chaperone.
Wilson MR, Easterbrook-Smith SB. | 05/4/2011 |
| Clusterin is an extracellular holdase-type chaperone | Clusterin has chaperone-like activity similar to that of small heat shock proteins.
Humphreys DT, Carver JA, Easterbrook-Smith SB, Wilson MR. | 05/4/2011 |
| Cellular RNA released from necrotic cells can act as an endogenous TLR3 ligand to induce clusterin expression in vitro in vascular smooth muscle cells and in vivo. | Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells.
Baiersdörfer M, Schwarz M, Seehafer K, Lehmann C, Heit A, Wagner H, Kirschning CJ, Koch-Brandt C. | 01/29/2011 |
| Reduced clusterin expression reduces the proliferation of VSMCs and induced G1 arrest via p53 and p21 | Deficiency of clusterin inhibits neointimal hyperplasia after vascular injury.
Shirasawa T, Miyata M, Eto H, Hamada N, Akasaki Y, Miyauchi T, Furusho Y, Orihara K, Hamasaki S, Aronow BJ, Smith JD, Tei C. | 04/12/2010 |
| Reduction of inducible expression of clusterin results in an increase in tubular cell apoptosis and renders mice prone to ischemia reperfusion injury, implying a protective role of clusterin in kidney injury. | Loss of clusterin expression worsens renal ischemia-reperfusion injury.
Zhou W, Guan Q, Kwan CC, Chen H, Gleave ME, Nguan CY, Du C. | 03/22/2010 |
| Clusterin facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and sperm membranes. | Clusterin facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and mouse and human sperm membranes.
Griffiths GS, Galileo DS, Aravindan RG, Martin-DeLeon PA., Free PMC Article | 01/21/2010 |
| CLU depletion causes tumourigenesis in female TRAMP mice, which are normally cancer free. | Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread.
Bettuzzi S, Davalli P, Davoli S, Chayka O, Rizzi F, Belloni L, Pellacani D, Fregni G, Astancolle S, Fassan M, Corti A, Baffa R, Sala A. | 01/21/2010 |
| upregulation of clusterin during vascular injury may be a protective response against, rather than a causative response to, the development of neointimal hyperplasia. | Protective role of clusterin/apolipoprotein J against neointimal hyperplasia via antiproliferative effect on vascular smooth muscle cells and cytoprotective effect on endothelial cells.
Kim HJ, Yoo EK, Kim JY, Choi YK, Lee HJ, Kim JK, Jeoung NH, Lee KU, Park IS, Min BH, Park KG, Lee CH, Aronow BJ, Sata M, Lee IK. | 01/21/2010 |
| Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. | Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules.
Kaisman-Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, Hershfinkel M, Silverman WF. | 01/21/2010 |
| First genetic evidence that clusterin is a tumor and metastasis suppressor gene. | Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.
Chayka O, Corvetta D, Dews M, Caccamo AE, Piotrowska I, Santilli G, Gibson S, Sebire NJ, Himoudi N, Hogarty MD, Anderson J, Bettuzzi S, Thomas-Tikhonenko A, Sala A., Free PMC Article | 01/21/2010 |
| clusterin expression is already present in fetal life mainly in subcortical structures in mouse. | Clusterin expression during fetal and postnatal CNS development in mouse.
Charnay Y, Imhof A, Vallet PG, Hakkoum D, Lathuiliere A, Poku N, Aronow B, Kovari E, Bouras C, Giannakopoulos P. | 01/21/2010 |
| In an in vitro model of ischemia characterized by the predominance of N-methyl-D-aspartate-mediated cell death, clusterin exerts a negative effect on the structural integrity and functionality of hippocampal neurons. | Clusterin increases post-ischemic damages in organotypic hippocampal slice cultures.
Hakkoum D, Imhof A, Vallet PG, Boze H, Moulin G, Charnay Y, Stoppini L, Aronow B, Bouras C, Giannakopoulos P. | 01/21/2010 |
| Clusterin inhibits NF-kappaB-mediated antiapoptotic effects by the apparent stabilization of IkappaBalpha switching from promoting inflammation to apoptosis during proteinuria. | Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis.
Takase O, Minto AW, Puri TS, Cunningham PN, Jacob A, Hayashi M, Quigg RJ. | 01/21/2010 |
| The antiapoptotic protein clusterin protects cardiomyocytes against ischemia-induced cell death. | The antiapoptotic protein clusterin protects cardiomyocytes against ischemia-induced cell death.
Krijnen PA, Niessen HW. | 01/21/2010 |
| nuclear CLU may play an important role in tientsin albinao 2 spontaneous breast cancer initiation and development. | Clusterin is associated with spontaneous breast cancer in TA2 mice.
Sun B, Zhang S, Zhang D, Liu Y, Li Y, Rong Z, Zhu Y, Jia X. | 01/21/2010 |
| These findings reveal several novel pathways for the regulation of clusterin expression during mammary gland development, and suggest that clusterin is a morphogenic factor that plays a key role during differentiation. | Regulation of clusterin expression in mammary epithelial cells.
Itahana Y, Piens M, Sumida T, Fong S, Muschler J, Desprez PY., Free PMC Article | 01/21/2010 |
| Failure of green tea catechin chemoprevention caused induction of both histone H3 and Gas1 and down-regulation of clusterin. | The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression.
Caporali A, Davalli P, Astancolle S, D'Arca D, Brausi M, Bettuzzi S, Corti A. | 01/21/2010 |