| Under basal conditions SK2 channels do not undergo rapid recycling and are present within the spine in a population of endosomes distinct from alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs). | Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors.
Lin MT, Luján R, Watanabe M, Frerking M, Maylie J, Adelman JP., Free PMC Article | 09/27/2010 |
| The functional roles of SK2 channels in whole animals are discussed, and a possible link is provided between abnormalities in cardiac SK2 channels and cardiac arrhythmias. | Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.
Li N, Timofeyev V, Tuteja D, Xu D, Lu L, Zhang Q, Zhang Z, Singapuri A, Albert TR, Rajagopal AV, Bond CT, Periasamy M, Adelman J, Chiamvimonvat N., Free PMC Article | 01/21/2010 |
| demonstrate that proper membrane localization of a small-conductance Ca(2+)-activated K(+) channel (SK2 or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein. | Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel).
Lu L, Timofeyev V, Li N, Rafizadeh S, Singapuri A, Harris TR, Chiamvimonvat N., Free PMC Article | 01/21/2010 |
| describe a deletion in the 5' region of the Kcnn2 gene encoding the SK2 subunit in the neurological frissonnant (fri) mutant. The frissonnant mutant phenotype is characterized by constant rapid tremor and locomotor instability. | Behavioral effects of a deletion in Kcnn2, the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channels.
Szatanik M, Vibert N, Vassias I, Guénet JL, Eugène D, de Waele C, Jaubert J. | 01/21/2010 |
| SK2 channels are required both for expression of functional nAChRs, and for establishment and/or maintenance of efferent terminals in the cochlea. | Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells.
Kong JH, Adelman JP, Fuchs PA., Free PMC Article | 01/21/2010 |
| SK2 null mice exhibit loss of nAChR-induced activity in mouse outer hair cells and efferent nerve fiber and synaptic boutons degeneration in the cochlea. SK2 is epistatic to the nAChR alpha10 gene as assessed in the SK2/alpha10 double null mouse. | SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells.
Murthy V, Maison SF, Taranda J, Haque N, Bond CT, Elgoyhen AB, Adelman JP, Liberman MC, Vetter DE, Murthy V, Maison SF, Taranda J, Haque N, Bond CT, Elgoyhen AB, Adelman JP, Liberman MC, Vetter DE., Free PMC Articles: PMC2661972, PMC2661972 | 02/6/2009 |
| Results suggest a hierarchy of activity necessary to maintain early olivocochlear synapses at their targets, with SK2 serving an epistatic, upstream, role to the nicotinic acetylcholine receptors. | SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells.
Murthy V, Maison SF, Taranda J, Haque N, Bond CT, Elgoyhen AB, Adelman JP, Liberman MC, Vetter DE, Murthy V, Maison SF, Taranda J, Haque N, Bond CT, Elgoyhen AB, Adelman JP, Liberman MC, Vetter DE., Free PMC Articles: PMC2661972, PMC2661972 | 01/21/2010 |
| Transgenic mice overexpressing SK2 channels (SK2+/T mice) exhibit marked deficits in hippocampal memory and synaptic plasticity. | Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficit.
Stackman RW Jr, Bond CT, Adelman JP., Free PMC Article | 01/21/2010 |
| SK2 gene is expressed in the bladder and that it is essential for the ability of SK channels to regulate urinary bladder smooth muscle contractility | Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder.
Thorneloe KS, Knorn AM, Doetsch PE, Lashinger ES, Liu AX, Bond CT, Adelman JP, Nelson MT., Free PMC Article | 01/21/2010 |
| Overexpression of SK2 channels results in the shortening of the spontaneous action potentials of the atrioventricular node cells and an increase in the firing frequency | Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes.
Zhang Q, Timofeyev V, Lu L, Li N, Singapuri A, Long MK, Bond CT, Adelman JP, Chiamvimonvat N., Free PMC Article | 01/21/2010 |
| SK2 channels have a functional influence on inner hair cells (IHC) during immature development. The altered Ca(2+) dependence of exocytosis in adult IHCs is likely to be a consequence of their disrupted action potential activity at immature stages. | Genetic deletion of SK2 channels in mouse inner hair cells prevents the developmental linearization in the Ca2+ dependence of exocytosis.
Johnson SL, Adelman JP, Marcotti W., Free PMC Article | 01/21/2010 |
| These findings suggest a possible transcriptional cross talk between glucocorticoid receptors and NF-kappaB in the intronic promoter regulation of SK2-S channel gene transcription. | Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids.
Kye MJ, Spiess J, Blank T. | 01/21/2010 |
| SK2 overexpressers were not protected from acoustic injury | Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance.
Maison SF, Parker LL, Young L, Adelman JP, Zuo J, Liberman MC., Free PMC Article | 01/21/2010 |
| SK2 channels regulate hippocampal synaptic plasticity and play a critical role in modulating mechanisms of learning and memory. | Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity.
Hammond RS, Bond CT, Strassmaier T, Ngo-Anh TJ, Adelman JP, Maylie J, Stackman RW., Free PMC Article | 01/21/2010 |
| SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion. | Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses.
Tamarina NA, Wang Y, Mariotto L, Kuznetsov A, Bond C, Adelman J, Philipson LH. | 01/21/2010 |
| the SK2 gene encodes two subunit proteins; native SK2-L subunits may preferentially partition into heteromeric channel complexes with other SK subunits | A novel isoform of SK2 assembles with other SK subunits in mouse brain.
Strassmaier T, Bond CT, Sailer CA, Knaus HG, Maylie J, Adelman JP. | 01/21/2010 |
| Here we report the cloning, characterization, and expression of a complete SK2 cDNA from the mouse cochlea. The cDNAs of the mouse cochlea alpha9 and alpha10 acetylcholine receptors were also obtained, sequenced, and coexpressed with the SK2 channels. | Cloning and expression of a small-conductance Ca(2+)-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors.
Nie L, Song H, Chen MF, Chiamvimonvat N, Beisel KW, Yamoah EN, Vázquez AE. | 01/21/2010 |
| Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes | Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts.
Xu Y, Tuteja D, Zhang Z, Xu D, Zhang Y, Rodriguez J, Nie L, Tuxson HR, Young JN, Glatter KA, Vázquez AE, Yamoah EN, Chiamvimonvat N. | 01/21/2010 |
| At the cellular level, SK2-like immunoreactivity is primarily localized to somatic and dendritic structures in mouse brain. | Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain.
Sailer CA, Kaufmann WA, Marksteiner J, Knaus HG. | 01/21/2010 |