| the Fas/FasL system regulates the acute lung inflammatory response by positively affecting CXC-chemokine production | Relationship of acute lung inflammatory injury to Fas/FasL system.
Neff TA, Guo RF, Neff SB, Sarma JV, Speyer CL, Gao H, Bernacki KD, Huber-Lang M, McGuire S, Hoesel LM, Riedemann NC, Beck-Schimmer B, Zetoune FS, Ward PA., Free PMC Article | 01/21/2010 |
| These results suggest a substantial contribution of FasL to granule exocytosis-mediated target cell lysis by CD8+ CTL and NK cells. | Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.
Kojima Y, Kawasaki-Koyanagi A, Sueyoshi N, Kanai A, Yagita H, Okumura K. | 01/21/2010 |
| FasL is not an effector molecule is corneal graft rejection. | The role of Fas ligand as an effector molecule in corneal graft rejection.
Stuart PM, Yin X, Plambeck S, Pan F, Ferguson TA. | 01/21/2010 |
| differential role of Fas/Fas-L and TNFRI/TNF pathways in atrophy of mesenteric lymph nodes in experimental Chagas' disease | Atrophy of mesenteric lymph nodes in experimental Chagas' disease: differential role of Fas/Fas-L and TNFRI/TNF pathways.
de Meis J, Mendes-da-Cruz DA, Farias-de-Oliveira DA, Corrêa-de-Santana E, Pinto-Mariz F, Cotta-de-Almeida V, Bonomo A, Savino W. | 01/21/2010 |
| IL-23 plays an important role in the FasL-induced IL-17 production. | Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production.
Kidoya H, Umemura M, Kawabe T, Matsuzaki G, Yahagi A, Imamura R, Suda T. | 01/21/2010 |
| cellular CD8(+)-dependent immune response, acting through the Fas/Fas ligand death pathway, could be mediating the antitumor effect induced by immunization with antisense oligodeoxynucleotides-treated cells | Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/Fas ligand cytotoxic pathway.
Schillaci R, Salatino M, Cassataro J, Proietti CJ, Giambartolomei GH, Rivas MA, Carnevale RP, Charreau EH, Elizalde PV. | 01/21/2010 |
| Proapoptotic and antiinflammatory effects of endogenous FasL are factors in process of neointimal lesion formation after balloon injury. Activation of FasL may decrease neointimal thickening after percutaneous coronary intervention. | Role of endogenous Fas (CD95/Apo-1) ligand in balloon-induced apoptosis, inflammation, and neointima formation.
Matter CM, Chadjichristos CE, Meier P, von Lukowicz T, Lohmann C, Schuler PK, Zhang D, Odermatt B, Hofmann E, Brunner T, Kwak BR, Lüscher TF. | 01/21/2010 |
| the ERK5 signaling pathway promotes cell survival by downregulating FasL expression via a mechanism that implicates PKB-dependent inhibition of Foxo3a downstream of phosphoinositide 3 kinase. | Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress.
Wang X, Finegan KG, Robinson AC, Knowles L, Khosravi-Far R, Hinchliffe KA, Boot-Handford RP, Tournier C. | 01/21/2010 |
| in FasL transgenic mice, choroidal neovascularization was inhibited through Fas-FasL-mediated apoptosis in a mouse model of laser-induced choroidal neovascularization | Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization.
Semkova I, Fauser S, Lappas A, Smyth N, Kociok N, Kirchhof B, Paulsson M, Poulaki V, Joussen AM. | 01/21/2010 |
| While FasL is a death-inducing ligand for Fas, it also transduces a costimulatory signal through its intracellular domain. | The cytoplasmic domain of Fas ligand costimulates TCR signals.
Sun M, Ames KT, Suzuki I, Fink PJ. | 01/21/2010 |
| CD4-dependent destruction of melanocytes is partially inhibited by blocking Fas-Fas ligand interactions | CD4 T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas-Fas ligand interactions.
Lambe T, Leung JC, Bouriez-Jones T, Silver K, Makinen K, Crockford TL, Ferry H, Forrester JV, Cornall RJ. | 01/21/2010 |
| 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) regulates Fas and FasL promoters through a dioxin response element and/or NF-kappaB motif via an aryl hydrocarbon receptor. | Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expression.
Singh NP, Nagarkatti M, Nagarkatti PS. | 01/21/2010 |
| Epithelial cell apoptosis and associated upregulation of Fas and apoptotic Fas pathway genes in epithelial cells of lungs with bleomycin-induced fibrosis. | Epithelial cell apoptosis by fas ligand-positive myofibroblasts in lung fibrosis.
Golan-Gerstl R, Wallach-Dayan SB, Amir G, Breuer R. | 01/21/2010 |
| findings indicate a reduction of immune privilege in decidua pre-eclampsia/fetal growth restriction pregnancies by reduced FasL expression and that decidual cells may have a central role in the Fas-FasL-based feto-maternal immune balance. | Fetal growth restriction is associated with reduced FasL expression by decidual cells.
Eide IP, Isaksen CV, Salvesen KA, Langaas M, Günther CC, Iversen AC, Austgulen R. | 01/21/2010 |
| FasL is among those genes whose expression is up-regulated by E2 through a direct interaction of ERalpha with Sp-1 protein. | Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol "in situ" production.
Catalano S, Rizza P, Gu G, Barone I, Giordano C, Marsico S, Casaburi I, Middea E, Lanzino M, Pellegrino M, Andò S. | 01/21/2010 |
| FasL-induced activator protein (AP)-1 activation is required for optimal IL-8 production. | Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production.
Matsumoto N, Imamura R, Suda T. | 01/21/2010 |
| Transgenic expression of Fas ligand on thyroid follicular cells leads to markedly decreased anti-allogeneic, cytotoxic, and helper T lymphocyte activities and prevents rejection of thyroid allografts. | Transgenic expression of CD95 ligand on thyroid follicular cells confers immune privilege upon thyroid allografts.
Tourneur L, Malassagne B, Batteux F, Fabre M, Mistou S, Lallemand E, Lores P, Chiocchia G. | 10/17/2001 |
| Fas ligand (CD95L) expression by individual hippocampal neurons is involved in protection against perforin-mediated T-lymphocyte cytotoxicity. | Fas ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity.
Medana I, Li Z, Flügel A, Tschopp J, Wekerle H, Neumann H. | 09/28/2001 |