| This study is the first to describe how CCN1 promotes VEGF expression in osteoblasts and increased endothelial progenitor cells angiogenesis in rheumatoid arthritis disease. | CCN1 Promotes VEGF Production in Osteoblasts and Induces Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-126 Expression in Rheumatoid Arthritis.
Chen CY, Su CM, Hsu CJ, Huang CC, Wang SW, Liu SC, Chen WC, Fuh LJ, Tang CH. | 01/13/2018 |
| Data show that cysteine rich protein 61 protein (CCN1) critically mediates doxorubicin (DOX)-induced cardiotoxicity. | Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice.
Hsu PL, Mo FE., Free PMC Article | 12/30/2017 |
| Our results not only reveal a novel mechanism illustrating the role of Cyr61 in epidermis pathogenesis but also suggest that therapies targeting Cyr61 may represent a novel strategy in the treatment of psoriasis vulgaris. | Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway.
Wu P, Ma G, Zhu X, Gu T, Zhang J, Sun Y, Xu H, Huo R, Wang B, Shen B, Chen X, Li N. | 06/24/2017 |
| The LPA1-CCN1 axis may be the central control for SMC migration. | Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61.
Hao F, Zhang F, Wu DD, An D, Shi J, Li G, Xu X, Cui MZ., Free PMC Article | 06/10/2017 |
| these data suggest that the WNT/beta-catenin signaling pathway enhances pancreatic cancer development and malignancy in part via up-regulation of CYR61. | Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.
Sano M, Driscoll DR, DeJesus-Monge WE, Quattrochi B, Appleman VA, Ou J, Zhu LJ, Yoshida N, Yamazaki S, Takayama T, Sugitani M, Nemoto N, Klimstra DS, Lewis BC., Free PMC Article | 05/6/2017 |
| Lysophosphatidic acid induced time-dependent phosphorylation of serum response factor and CRE-binding protein in in smooth muscle cells, inducing transcription of CCN1. | CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells.
Dou Q, Hao F, Sun L, Xu X, Cui MZ., Free PMC Article | 03/25/2017 |
| Data show that Cysteine-rich 61 (CYR61) acts as a tumor-promoting gene in pancreatic neuroendocrine tumors. | The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression.
Huang YT, Lan Q, Ponsonnet L, Blanquet M, Christofori G, Zaric J, Rüegg C., Free PMC Article | 12/17/2016 |
| CCN1 is an important regulator of chondrocyte maturation during cartilage development and homeostasis. | CCN1 Regulates Chondrocyte Maturation and Cartilage Development.
Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ., Free PMC Article | 12/17/2016 |
| CCN1 exacerbates tracheal obliterative bronchiolitis by enhancing fibroproliferation via an alphavbeta3-integrin-independent pathway. | Systemic overexpression of matricellular protein CCN1 exacerbates obliterative bronchiolitis in mouse tracheal allografts.
Raissadati A, Nykänen AI, Tuuminen R, Syrjälä SO, Krebs R, Arnaudova R, Rouvinen E, Wang X, Poller W, Lemström KB. | 10/29/2016 |
| Data show that RNA silencing of CCN family member 1 protein (CCN1) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling in mouse pup model of oxygen-induced retinopathy (OIR). | CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.
Di Y, Zhang Y, Nie Q, Chen X., Free PMC Article | 09/17/2016 |
| CCN genes are activated in heart failure. | Transcriptional and post-transcriptional regulation of CCN genes in failing heart.
Bonda TA, Kożuch M, Litvinovich S, Bialuk I, Taranta A, Lipiec P, Szymczyk E, Musiał WJ, Winnicka MM, Kamiński KA. | 09/10/2016 |
| These findings reveal a critical role for CCN1 in restoring mucosal homeostasis after intestinal injury | The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6.
Choi JS, Kim KH, Lau LF., Free PMC Article | 08/20/2016 |
| CCN1 is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR-dependent hepatocyte compensatory proliferation | The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
Chen CC, Kim KH, Lau LF., Free PMC Article | 07/30/2016 |
| Both knockin mice expressing a mutant CCN1 that is unable to bind alphavbeta3/alphavbeta5 and mice with Ccn1 knockdown are defective in neutrophil efferocytosis, resulting in exuberant neutrophil accumulation and delayed healing. | The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing.
Jun JI, Kim KH, Lau LF., Free PMC Article | 04/9/2016 |
| CYR61 is upregulated in acute lung injury (ALI) and CYR61 overexpression exacerbates ALI in mice. | CYR61 (CCN1) overexpression induces lung injury in mice.
Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, Altemeier WA, Matute-Bello G., Free PMC Article | 01/2/2016 |
| miR-155 functions in tandem with CCN1 to modulate inflammation-induced vascular homeostasis and repair. | Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia.
Yan L, Lee S, Lazzaro DR, Aranda J, Grant MB, Chaqour B., Free PMC Article | 12/19/2015 |
| MRTF-A promotes microvessel growth (via CCN1) and maturation (via CCN2), thereby enabling functional improvement of ischaemic muscle tissue | MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. | 12/5/2015 |
| CCN1-integrin binding increased the expression of and association between SHP-1 and VEGF-R2, which leads to rapid dephosphorylation of VEGF-R2 tyrosine, thus preventing endothelial cell hyperproliferation. | The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.
Chintala H, Krupska I, Yan L, Lau L, Grant M, Chaqour B., Free PMC Article | 09/26/2015 |
| CYR61 silencing can blunt the malignant behavior of osteosarcoma tumor cells by limiting primary tumor growth and dissemination process. | Cyr61 silencing reduces vascularization and dissemination of osteosarcoma tumors.
Habel N, Vilalta M, Bawa O, Opolon P, Blanco J, Fromigué O. | 08/29/2015 |
| Knock-in mice expressing a CCN1 mutant that is unable to bind alphavbeta5/alphavbeta3 were impaired in ductular reaction. CCN1, acting through its alphav beta3/alphav beta5 binding site, is critical for survival after bile duct ligation. | CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.
Kim KH, Chen CC, Alpini G, Lau LF., Free PMC Article | 08/22/2015 |
| Findings reveal that CCN1 plays a novel role in pathogen clearance; increasing macrophage infiltration and activation resulting in increased virus clearance in tumors. | Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance.
Thorne AH, Meisen WH, Russell L, Yoo JY, Bolyard CM, Lathia JD, Rich J, Puduvalli VK, Mao H, Yu J, Caligiuri MA, Tridandapani S, Kaur B., Free PMC Article | 07/25/2015 |
| Extracellular Cyr61 convergence with growth factor signaling and integrin/FAK signaling is a new concept of growth factor-induced cell migration. | The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration.
Zhang F, Hao F, An D, Zeng L, Wang Y, Xu X, Cui MZ., Free PMC Article | 06/6/2015 |
| These findings implicate CCN1 as a mediator of cardioprotection induced by G-protein coupled receptor agonists that activate RhoA/MRTF-A signaling. | Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.
Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S., Free PMC Article | 05/23/2015 |
| Our results here reveal a novel role of Cyr61 in the pathogenesis of rheumatoid arthritis | Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis.
Zhu X, Xiao L, Huo R, Zhang J, Lin J, Xie J, Sun S, He Y, Sun Y, Zhou Z, Shen B, Li N., Free PMC Article | 11/8/2014 |
| Findings suggest that that cysteine-rich 61 protein (cyr61) is expressed in airway epithelial cells and has a positive correlation with eotaxin and number of airway infiltrating eosinophils. | Inhibitory effect of dexamethasone on expression of cysteine-rich 61 protein in airway epithelial cells of allergic mouse models.
Cao Y, Chen HL, Cheng S, Xie JG, Xiong WN, Xu YJ, Fang HJ. | 11/8/2014 |