| It provides evidence that CCN1 is released from activated platelets, suggesting that platelets constitute a novel source for CCN1 release to the circulation during sepsis. | The matricellular "cysteine-rich protein 61" is released from activated platelets and increased in the circulation during experimentally induced sepsis.
Hviid CV, Samulin Erdem J, Drechsler S, Weixelbaumer K, Ahmed MS, Attramadal H, Redl H, Bahrami S, Osuchowski MF, Aasen AO. | 10/18/2014 |
| Binding of CYR61 to LFA-1, ICAM-1 and integrin alpha6 supports the adhesion of thymic epithelial cells and T-cell. | Thymic epithelial cell expansion through matricellular protein CYR61 boosts progenitor homing and T-cell output.
Emre Y, Irla M, Dunand-Sauthier I, Ballet R, Meguenani M, Jemelin S, Vesin C, Reith W, Imhof BA. | 10/11/2014 |
| these data reveal that de novo Cyr61 in the extracellular matrix bridges LPA and integrin pathways, which in turn, activate FAK, leading to cell migration. | Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration.
Wu DD, Zhang F, Hao F, Chun J, Xu X, Cui MZ., Free PMC Article | 04/26/2014 |
| CCN1 protein expression is increased in aging skeletal muscle. | Aging increases CCN1 expression leading to muscle senescence.
Du J, Klein JD, Hassounah F, Zhang J, Zhang C, Wang XH., Free PMC Article | 03/1/2014 |
| The aim of the study was to evaluate CCN1 protein abundance and localization in the kidney of IL-6-deficient C57BL/6J (IL-6 KO) mice. | CCN1 expression in interleukin-6 deficient mouse kidney in experimental model of heart failure.
Bonda TA, Taranta A, Kaminski KA, Dziemidowicz M, Litvinovich S, Kozuch M, Bialuk I, Chyczewski L, Winnicka MM. | 01/18/2014 |
| Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina. | Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina.
Choi J, Lin A, Shrier E, Lau LF, Grant MB, Chaqour B., Free PMC Article | 11/2/2013 |
| role of Cyr61 in obstructive kidney fibrosis | Cysteine-rich protein 61 plays a proinflammatory role in obstructive kidney fibrosis.
Lai CF, Chen YM, Chiang WC, Lin SL, Kuo ML, Tsai TJ., Free PMC Article | 08/31/2013 |
| the potential roles of CCN1 in the inflammation and macrophage infiltration of nonalcoholic fatty liver disease ( | CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice.
Bian Z, Peng Y, You Z, Wang Q, Miao Q, Liu Y, Han X, Qiu D, Li Z, Ma X., Free PMC Article | 06/1/2013 |
| the matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis | The matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis.
Haque I, De A, Majumder M, Mehta S, McGregor D, Banerjee SK, Van Veldhuizen P, Banerjee S., Free PMC Article | 02/2/2013 |
| It conclude that in the murine atria, CCN1 and CCN2 proteins are expressed constitutively. In chronic heart failure, CCN proteins tend to be upregulated, which may be related to the action of angiotensin II. | Atrial expression of the CCN1 and CCN2 proteins in chronic heart failure.
Bonda TA, Kamiński KA, Dziemidowicz M, Litvinovich S, Kożuch M, Hirnle T, Dmitruk I, Chyczewski L, Winnicka MM. | 11/3/2012 |
| The expressions of Cyr61, MMP-2, and VEGF at the levels of mRNA and protein were decreased in the QYHJ groups. | Qingyihuaji formula inhibits progress of liver metastases from advanced pancreatic cancer xenograft by targeting to decrease expression of Cyr61 and VEGF.
Yin JH, Shi WD, Zhu XY, Chen Z, Liu LM. | 10/20/2012 |
| a novel, VEGF-independent, clinically relevant, pro-angiogenic factor, CYR61, that is a transcriptional target of Hh-GLI signaling | Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.
Harris LG, Pannell LK, Singh S, Samant RS, Shevde LA., Free PMC Article | 09/22/2012 |
| Cyr61 expression increases with tumor grade in human osteosarcoma and demonstrate that cyr61 silencing inhibits in vitro osteosarcoma cell invasion and migration as well as in vivo lung metastases in mice. | CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis.
Fromigue O, Hamidouche Z, Vaudin P, Lecanda F, Patino A, Barbry P, Mari B, Marie PJ. | 10/15/2011 |
| Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions. | G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.
Kim YM, Lim SC, Han CY, Kay HY, Cho IJ, Ki SH, Lee MY, Kwon HM, Lee CH, Kim SG. | 05/21/2011 |
| newly identified functions of CCN1 suggest its possible therapeutic utility in ischemic retinopathy. | The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy.
Hasan A, Pokeza N, Shaw L, Lee HS, Lazzaro D, Chintala H, Rosenbaum D, Grant MB, Chaqour B., Free PMC Article | 05/21/2011 |
| extracellular matrix protein CCN1 dictates TNFalpha and FasL cytotoxicity | The extracellular matrix protein CCN1 dictates TNFα and FasL cytotoxicity in vivo.
Chen CC, Juric V, Lau LF., Free PMC Article | 04/16/2011 |
| CYR61 up-regulates BMP-2 mRNA and protein expression, resulting in enhanced cell proliferation and osteoblastic differentiation through activation of the alpha(v)beta(3) integrin/integrin-linked kinase/ERK signaling pathway. | CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway.
Su JL, Chiou J, Tang CH, Zhao M, Tsai CH, Chen PS, Chang YW, Chien MH, Peng CY, Hsiao M, Kuo ML, Yen ML., Free PMC Article | 11/6/2010 |
| Fas-dependent hepatic apoptosis induced by an agonistic monoclonal anti-Fas antibody or intragastric administration of alcohol is severely blunted in knock-in mice expressing an apoptosis-defective Ccn1 allele. | Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.
Juric V, Chen CC, Lau LF., Free PMC Article | 01/21/2010 |
| Data suggest that signal-controlled activation of SRF, MRTF-A, and CBP provides a novel connection between mechanical stimuli and CCN1 gene expression. | Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.
Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, Lau LF, Chaqour B., Free PMC Article | 01/21/2010 |
| Caveolin-1 (cav-1)/Cyr61 interaction via integrins represents a novel pathway of Cyr61 signaling involving cav-1-dependent processes, which play a critical role in regulating hyperoxia-induced cell death | Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death.
Jin Y, Kim HP, Cao J, Zhang M, Ifedigbo E, Choi AM., Free PMC Article | 01/21/2010 |
| The Cyr61 protein, a product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells. | Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells.
Wong M, Kireeva ML, Kolesnikova TV, Lau LF. | 12/23/2008 |
| Intracolonic overexpression of CCN1 induced angiogenesis in mouse colon. | Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis.
Koon HW, Zhao D, Xu H, Bowe C, Moss A, Moyer MP, Pothoulakis C., Free PMC Article | 01/21/2010 |
| We demonstrate that infection of epithelial cells with attenuated Yersinia enterocolitica lacking the virulence plasmid pYV leads to the expression of CYR61 and CTGF. | Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner.
Wiedmaier N, Müller S, Köberle M, Manncke B, Krejci J, Autenrieth IB, Bohn E. | 01/21/2010 |
| These findings establish CYR61 as a novel and essential regulator of vascular development. | CYR61 (CCN1) is essential for placental development and vascular integrity.
Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF., Free PMC Article | 01/21/2010 |
| Expression of Cyr61 is induced in fibroblasts through plasmin-induced activation of the protease-activated receptor-1 signaling pathway. | Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway.
Pendurthi UR, Ngyuen M, Andrade-Gordon P, Petersen LC, Rao LV. | 01/21/2010 |