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    Il2rg interleukin 2 receptor, gamma chain [ Mus musculus (house mouse) ]

    Gene ID: 16186, updated on 30-Nov-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    gamma c deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.

    Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.
    Decaluwe H, Taillardet M, Corcuff E, Munitic I, Law HK, Rocha B, Rivière Y, Di Santo JP., Free PMC Article

    07/26/2010
    dengue virus infection and virus-specific HLA-A2 restricted immune response does not require IL2rgamma

    Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
    Jaiswal S, Pearson T, Friberg H, Shultz LD, Greiner DL, Rothman AL, Mathew A., Free PMC Article

    03/15/2010
    High expression of the cytokine receptor common gamma-chain confers longevity of intestinal eosinophils and suggests that common gamma-chain-dependent tissue- intrinsic signals contribute to eosinophil homeostasis.

    Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.
    Carlens J, Wahl B, Ballmaier M, Bulfone-Paus S, Förster R, Pabst O.

    01/21/2010
    Evidence supports complementary and essential roles for IL2Rg and FMS-like tyrosine kinase 3 ligand Flt3l in regulation of developing thymic and bone marrow natural killer (NK) cell compartments.

    Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.
    Cheng M, Charoudeh HN, Brodin P, Tang Y, Lakshmikanth T, Höglund P, Jacobsen SE, Sitnicka E.

    01/21/2010
    Different gamma chain cytokines regulate regulatory T cell homeostasis in the periphery by differentially regulating survival and proliferation.

    The control of CD4+CD25+Foxp3+ regulatory T cell survival.
    Pandiyan P, Lenardo MJ., Free PMC Article

    01/21/2010
    naive T cells can be induced to undergo homeostatic proliferation of variable speed with a few members of the common gamma-chain (CD132) family of cytokines, the speed of proliferation depending on the levels of the particular cytokine involved.

    The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15.
    Ramsey C, Rubinstein MP, Kim DM, Cho JH, Sprent J, Surh CD.

    01/21/2010
    Stat5 has a role in severe combined immunodeficiency, similar in many respects to the roles of IL-7R, gammac, and Jak3

    Stat5a/b are essential for normal lymphoid development and differentiation.
    Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O'Shea JJ., Free PMC Article

    01/21/2010
    The estrous cycles in gamma(c) knockout (gamma(c) KO) mice were irregular compared with wild-type mice, although, the mutants could become pregnant.

    Interleukin 2 receptor gamma chain (gamma(c)) knockout mice show less regularity in estrous cycle but achieve normal pregnancy without fetal compromise.
    Miyazaki S, Tanebe K, Sakai M, Michimata T, Tsuda H, Fujimura M, Nakamura M, Kiso Y, Saito S.

    01/21/2010
    Colonic IL-6-producing thymus-derived CD4 + T cells are responsible for the development of colitis in CR gamma -/Y mice.

    Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.
    Kai Y, Takahashi I, Ishikawa H, Hiroi T, Mizushima T, Matsuda C, Kishi D, Hamada H, Tamagawa H, Ito T, Yoshizaki K, Kishimoto T, Matsuda H, Kiyono H.

    01/21/2010
    Effector mechanisms in nonobese diabetic (NOD) hosts are inherently complex, and islet allograft rejection in this model involves common gamma-chain-dependent and -independent mechanisms.

    Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms.
    Demirci G, Strom TB, Li XC.

    01/21/2010
    Although IL-2 has been reported to influence natural killer (NK) cell differentiation, mice deficient in IL-2 common gamma chain receptor subunit have normal NK cell numbers, phenotype, and effector functions.

    Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo.
    Vosshenrich CA, Ranson T, Samson SI, Corcuff E, Colucci F, Rosmaraki EE, Di Santo JP.

    01/21/2010
    Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain

    Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.
    Olosz F, Malek TR.

    01/21/2010
    These data suggest that IRS-dependent signaling pathways work by recruiting different signaling molecules to determine specificity of IL-2R gamma superfamily cytokines.

    Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway.
    Xiao H, Yin T, Wang XY, Uchida T, Chung J, White MF, Yang YC.

    01/21/2010
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