| Studies show that acute loss of LPL can be produced and leads to rapid alteration in gene expression and cardiac dysfunction. | Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction.
Noh HL, Okajima K, Molkentin JD, Homma S, Goldberg IJ. | 01/21/2010 |
| thiazolidinediones upregulate the adipocyte lipid storage genes DGAT and FAS but have no significant effect on LPL | The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment.
Ranganathan G, Unal R, Pokrovskaya I, Yao-Borengasser A, Phanavanh B, Lecka-Czernik B, Rasouli N, Kern PA., Free PMC Article | 01/21/2010 |
| Endothelial cell associated lipoprotein lipase (LPL), either active or inactive, in the arterial wall is a strong proatherosclerotic factor in both LPL- and ApoE-deficient mice. | Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.
Wang J, Xian X, Huang W, Chen L, Wu L, Zhu Y, Fan J, Ross C, Hayden MR, Liu G. | 01/21/2010 |
| RAP binds to LPL with high affinity both in purified systems and cell extracts and RAP-deficient adipocytes secrete poorly assembled LPL | Interaction of lipoprotein lipase and receptor-associated protein.
Page S, Judson A, Melford K, Bensadoun A. | 01/21/2010 |
| LPL activity can be inhibited by endogenous apoC-I in apoE-knockout mice. | Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL.
Westerterp M, de Haan W, Berbée JF, Havekes LM, Rensen PC. | 01/21/2010 |
| Decrease of LPL activity in the heart, along with the inhibitory effects of excess apolipoprotein C-II, may contribute to the hypertriglyceridemia observed in apolipoprotein c-ii transgenic mice. | Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle.
Pulawa LK, Jensen DR, Coates A, Eckel RH. | 01/21/2010 |