| increased FXIII activity is associated with an increased risk of MI in young patients. None of studied single genetic variants-F13A1 Val34Leu, THBS2 T/G 3'UTR and THBS4 Ala387Pro-and the extended CC/TT/GG haplotype of F13A1/THBS2/THBS4 genes was associated with MI in young age. | Increased coagulation factor XIII activity but not genetic variants of coagulation factors is associated with myocardial infarction in young patients.
Ambroziak M, Kuryłowicz A, Budaj A., Free PMC Article | 02/22/2020 |
| beta-barrel 1 domain protects the active site cysteine in the FXIII protransglutaminase, whereas the beta-barrel 2 domain is necessary for exposure of the active site cysteine during activation. | The role of β-barrels 1 and 2 in the enzymatic activity of factor XIII A-subunit.
Hethershaw EL, Adamson PJ, Smith KA, Goldsberry WN, Pease RJ, Radford SE, Grant PJ, Ariëns RAS, Maurer MC, Philippou H., Free PMC Article | 09/21/2019 |
| this first South Asian study suggests neither protective nor deleterious effects of the F13A1 Val34Leu polymorphism on the risk of MI in young persons. The Leu allele frequency is intermediate to that reported from the West and the Far East. Traditional risk factors contribute greatly to risk even in younger MI patients in South Asia. | Coagulation F13A1 V34L, fibrinogen and homocysteine versus conventional risk factors in the pathogenesis of MI in young persons.
Vishwajeet V, Jamwal M, Sharma P, Das R, Ahluwalia J, Dogra RK, Rohit MK. | 09/7/2019 |
| F13A1 rs5985(c.103G > T (p.Val35Leu)) is associated with lower risk of aneurysmal subarachnoid hemorrhage (aSAH) but F13A1 rs5982(c.1694C > T (p.Pro564Leu)) is associated with higher risk of aSAH in South Indian population. | Factor XIII polymorphism and risk of aneurysmal subarachnoid haemorrhage in a south Indian population.
Suvatha A, Sibin MK, Bhat DI, Narasingarao KVL, Vazhayil V, Chetan GK., Free PMC Article | 06/1/2019 |
| Using Western blotting, kinetic assays, and microfluidic analyses, the study shows that FXIIIa covalently cross-links ABETA40 into dimers and oligomers (k cat/Km = 1.5 x 10(5) m(-1)s(-1)), as well as to fibrin, platelet proteins, and blood clots under flow in vitro ABETA40 also increased the stiffness of platelet-rich plasma clots in the presence of FXIIIa. | Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins.
Hur WS, Mazinani N, Lu XJD, Yefet LS, Byrnes JR, Ho L, Yeon JH, Filipenko S, Wolberg AS, Jefferies WA, Kastrup CJ., Free PMC Article | 05/4/2019 |
| this study characterized a novel mutation in AP-FXIII representing only the fourth case of the rare FXIII-A type II deficiency | Proline 36 of the Factor XIII Activation Peptide Plays a Crucial Role in Substrate Recognition and Zymogen Activation.
Li B, Billur R, Maurer MC, Kohler HP, Raddatz Müller P, Alberio L, Schroeder V., Free PMC Article | 02/2/2019 |
| Overall, genetically-determined FXIIIA levels have a significant long-term prognostic role, suggesting that a pharmacogenetics approach might help to select those AMI patients at risk of poor prognosis in the need of dedicated treatments. | F13A1 Gene Variant (V34L) and Residual Circulating FXIIIA Levels Predict Short- and Long-Term Mortality in Acute Myocardial Infarction after Coronary Angioplasty.
Ansani L, Marchesini J, Pestelli G, Luisi GA, Scillitani G, Longo G, Milani D, Serino ML, Tisato V, Gemmati D., Free PMC Article | 12/29/2018 |
| Inflammatory monocytes highly express Factor XIIIA, which promotes fibrin cross-linking to create a scaffold for lung squamous carcinomas cell invasion and metastases. | Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking.
Porrello A, Leslie PL, Harrison EB, Gorentla BK, Kattula S, Ghosh SK, Azam SH, Holtzhausen A, Chao YL, Hayward MC, Waugh TA, Bae S, Godfrey V, Randell SH, Oderup C, Makowski L, Weiss J, Wilkerson MD, Hayes DN, Earp HS, Baldwin AS, Wolberg AS, Pecot CV., Free PMC Article | 12/22/2018 |
| Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients | Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients.
Balogh L, Katona É, Mezei ZA, Kállai J, Gindele R, Édes I, Muszbek L, Papp Z, Bereczky Z. | 11/3/2018 |
| Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women. | Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.
Xu Z, Zhang Y, Liu W, Liu Y, Su Y, Xing Q, He X, Wei Z, Cao Y, Xiang H., Free PMC Article | 10/27/2018 |
| Coagulation factor FXIII-A (FXIIIA) was found to express specifically in the fetal beta islets but not in the alpha/delta islets. | Human Fetal β Islets Express Coagulation Factor XIII-A and Proteases Suggesting Amphicrine Regulation to Facilitate Islet Fusion.
Lee I. | 10/13/2018 |
| Factor XIIIa (AC-1A1) is a sensitive and specific nuclear marker for sebaceous differentiation...which can be utilized to aid in the diagnosis of sebaceous neoplasms. | Evaluation and comparison of staining patterns of factor XIIIa (AC-1A1), adipophilin and GATA3 in sebaceous neoplasia.
Tjarks BJ, Pownell BR, Evans C, Thompson PA, Kerkvliet AM, Koch MRD, Jassim AD. | 08/11/2018 |
| Our meta-analysis supports an association between F13A1 Val34Leu and recurrent pregnancy loss. | Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss: A meta-analysis.
Jung JH, Kim JH, Song GG, Choi SJ. | 04/28/2018 |
| A brief history of some key events in the conversion of fibrinogen to fibrin has been reviewed. (Review) | The conversion of fibrinogen to fibrin: A brief history of some key events.
Doolittle RF. | 03/3/2018 |
| The results of this study suggest that these biomarker F13A1 can serve as a potential non-invasive early diagnosis platform reflecting PiB-PET imaging for Mild Cognitive Impairment and Alzheimer's Disease. | PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease.
Kang S, Jeong H, Baek JH, Lee SJ, Han SH, Cho HJ, Kim H, Hong HS, Kim YH, Yi EC, Seo SW, Na DL, Hwang D, Mook-Jung I. | 02/3/2018 |
| F13A1 gene mutations in 73 patients treated with recombinant FXIII-A2 | Comparison of F13A1 gene mutations in 73 patients treated with recombinant FXIII-A(2).
Ivaškevičius V, Biswas A, Garly ML, Oldenburg J. | 12/2/2017 |
| Results show that the missense mutations-causing mild FXIII de fi ciency influence different aspects of FXIII function and can be functionally categorized on the basis of their expression phenotype. | Coagulation Factor XIIIA Subunit Missense Mutations Affect Structure and Function at the Various Steps of Factor XIII Action.
Thomas A, Biswas A, Dodt J, Philippou H, Hethershaw E, Ensikat HJ, Ivaskevicius V, Oldenburg J. | 11/11/2017 |
| These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations. | The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
Byrnes JR, Wilson C, Boutelle AM, Brandner CB, Flick MJ, Philippou H, Wolberg AS., Free PMC Article | 08/5/2017 |
| FXIIIa exhibits a preference for Q237 in crosslinking reactions within fibrinogen alphaC (233-425) followed by Q328 and Q366. | Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant factor XIII.
Mouapi KN, Bell JD, Smith KA, Ariëns RA, Philippou H, Maurer MC., Free PMC Article | 06/24/2017 |
| factor XIII Val34Leu polymorphism is associated with coronary artery diseases risk, especially myocardial infarction. Age and sex did not affect the relationship between factor XIII Val34Leu polymorphism and diseases risk (Meta-Analysis) | Association of factor XIII Val34Leu polymorphism and coronary artery disease: A meta-analysis.
Jung JH, Song GG, Kim JH, Seo YH, Choi SJ. | 05/20/2017 |
| Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. This condensed review discusses recent advances in the understanding of the novel intracellular and extracellular functions of platelet FXIII-A. [review] | Novel aspects of platelet factor XIII function.
Mitchell JL, Mutch NJ. | 04/1/2017 |
| It is a unique case showing the combination of a highly aggressive angiosarcoma and presence of inherited FXIII deficiency. It is also a rare example demonstrating the benefit of FXIII genotyping besides the expected acquired FXIII deficiency possibly due to neoplasm induced increased consumption by elevated crosslinking of fibrin fibers. | Neoplasm-induced bleeding in inherited, heterozygous FXIII-A deficiency.
Ivaškevičius V, Goldmann G, Biswas A, Westhofen P, Thomas A, Marquardt N, Horneff S, Klein C, Rühl H, Pötzsch B, Oldenburg J. | 12/17/2016 |
| The Val34Leu polymorphism of FXIII was not found in Korean people, and compared with Caucasians, a noticeably low incidence of deep vein thrombosis was shown. | Prevalence of the Factor XIII Val34Leu Polymorphism in Korean Patients with Deep Vein Thrombosis.
Kim SD, Hwang JK, Park SC, Kim JI, Won YS, Yun SS, Moon IS, Park JS. | 12/17/2016 |
| Genetic basis of severe factor XIII deficiency in a large cohort of Indian patients has been uncovered. | Genetic basis of severe factor XIII deficiency in a large cohort of Indian patients: Identification of fourteen novel mutations.
Shanbhag S, Ghosh K, Shetty S. | 10/29/2016 |
| Our meta-analysis suggests that there is no evidence for strong association between FXIII Val34Leu polymorphisms and intracerebral hemorrhage--{review} | Blood coagulation factor XIII-A subunit Val34Leu polymorphisms and intracerebral hemorrhage risk: A meta-analysis of case-control studies.
Ma J, Li H, You C, Liu Y, Ma L, Huang S. | 09/17/2016 |