Tumor necrosis factor-alpha knockout mitigates intestinal inflammation and tumorigenesis in obese Apc[1638N] mice. | Tumor necrosis factor-α knockout mitigates intestinal inflammation and tumorigenesis in obese Apc(1638N) mice. Li J, Tang Y, Lin TC, Zeng H, Mason JB, Liu Z. | 05/22/2023 |
Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver-derived TNF-alpha in senescence-accelerated mice. | Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver-derived TNF-α in senescence-accelerated mice. Shirakami Y, Kato J, Maeda T, Ideta T, Imai K, Sakai H, Shiraki M, Shimizu M. | 05/18/2023 |
Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression. | Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression. Sharma GP, Kosuru R, Lakshmikanthan S, Zheng S, Chen Y, Burns R, Xin G, Cui W, Chrzanowska M. | 04/26/2023 |
Wnt3a/YTHDF1 Regulated Oxaliplatin-Induced Neuropathic Pain Via TNF-alpha/IL-18 Expression in the Spinal Cord. | Wnt3a/YTHDF1 Regulated Oxaliplatin-Induced Neuropathic Pain Via TNF-α/IL-18 Expression in the Spinal Cord. Bai X, Huang Y, Huang W, Zhang Y, Zhang K, Li Y, Ouyang H. | 04/10/2023 |
Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor alpha Axis. | Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor α Axis. Zhou Q, Yang L, Verne ML, Zhang BB, Fields J, Verne GN., Free PMC Article | 03/28/2023 |
Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice. | Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice. McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Kovacs EJ., Free PMC Article | 03/22/2023 |
NOX1 is essential for TNFalpha-induced intestinal epithelial ROS secretion and inhibits M cell signatures. | NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures. Hsu NY, Nayar S, Gettler K, Talware S, Giri M, Alter I, Argmann C, Sabic K, Thin TH, Ko HM, Werner R, Tastad C, Stappenbeck T, Azabdaftari A, Uhlig HH, Chuang LS, Cho JH., Free PMC Article | 03/13/2023 |
TNF-alpha Limits Serological Memory by Disrupting the Bone Marrow Niche. | TNF-α Limits Serological Memory by Disrupting the Bone Marrow Niche. Aaron T, Laudermilch E, Benet Z, Ovando LJ, Chandran K, Fooksman D., Free PMC Article | 03/11/2023 |
Early TNF-Dependent Regulation of Excitatory and Inhibitory Synapses on Striatal Direct Pathway Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease. | Early TNF-Dependent Regulation of Excitatory and Inhibitory Synapses on Striatal Direct Pathway Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease. Chambon J, Komal P, Lewitus GM, Kemp GM, Valade S, Adaïdi H, Al Bistami N, Stellwagen D., Free PMC Article | 02/4/2023 |
Tumor necrosis factor-alpha-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model. | Tumor necrosis factor-α-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model. Li J, Pan Y, Yang J, Wang J, Jiang Q, Dou H, Hou Y., Free PMC Article | 01/14/2023 |
Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress. | Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress. Kemp GM, Altimimi HF, Nho Y, Heir R, Klyczek A, Stellwagen D., Free PMC Article | 01/11/2023 |
Extracellular vesicles of Clonorchis sinensis promote IL-6 and TNF-alpha secretion via the Toll-like receptor 9-mediated ERK pathway in biliary epithelial cells. | Extracellular vesicles of Clonorchis sinensis promote IL-6 and TNF-α secretion via the Toll-like receptor 9-mediated ERK pathway in biliary epithelial cells. Wang Y, Wang X, Zhang N, Yu Y, Bao P, Ma Y, Zhang H, Zhang X, Zhang X, Gong P, Li X, Li J. | 12/17/2022 |
Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-alpha/Bcl-2 pathway in male mice. | Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-α/Bcl-2 pathway in male mice. Zhu H, Wang H, Cheng Y, Liu D, Zhang A, Wen Z, Gao J. | 12/3/2022 |
Hypothalamic AgRP neurons exert top-down control on systemic TNF-alpha release during endotoxemia. | Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia. Boutagouga Boudjadja M, Culotta I, De Paula GC, Harno E, Hunter J, Cavalcanti-de-Albuquerque JP, Luckman SM, Hepworth M, White A, Aviello G, D'Agostino G. | 11/19/2022 |
Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis. | Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis. Zhou X, Huang F, Ma G, Wei W, Wu N, Liu Z., Free PMC Article | 11/5/2022 |
Double-negative T cells mediate M1 polarization of microglial cells via TNF-alpha-NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice. | Double-negative T cells mediate M1 polarization of microglial cells via TNF-α-NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice. Han C, Sheng Y, Wang J, Zhou X, Li W, Zhang C, Guo L, Yang Y. | 10/22/2022 |
Lack of Nogo-B expression ameliorates PPARgamma deficiency-aggravated liver fibrosis by regulating TLR4-NF-kappaB-TNF-alpha axis and macrophage polarization. | Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization. Zhao D, Xue C, Yang Y, Li J, Wang X, Chen Y, Zhang S, Chen Y, Duan Y, Yang X, Han J. | 09/24/2022 |
The Mechanism of TNF-alpha-Mediated Accumulation of Phosphorylated Tau Protein and Its Modulation by Propofol in Primary Mouse Hippocampal Neurons: Role of Mitophagy, NLRP3, and p62/Keap1/Nrf2 Pathway. | The Mechanism of TNF-α-Mediated Accumulation of Phosphorylated Tau Protein and Its Modulation by Propofol in Primary Mouse Hippocampal Neurons: Role of Mitophagy, NLRP3, and p62/Keap1/Nrf2 Pathway. Zhang L, Song H, Ding J, Wang DJ, Zhu SP, Liu C, Jin X, Chen JW., Free PMC Article | 09/17/2022 |
Sensitization of colonic nociceptors by TNFalpha is dependent on TNFR1 expression and p38 MAPK activity. | Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity. Barker KH, Higham JP, Pattison LA, Taylor TS, Chessell IP, Welsh F, Smith ESJ, Bulmer DC., Free PMC Article | 09/17/2022 |
Elevated TNF-alpha Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8. | Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8. Feinberg PA, Becker SC, Chung L, Ferrari L, Stellwagen D, Anaclet C, Durán-Laforet V, Faust TE, Sumbria RK, Schafer DP., Free PMC Article | 08/20/2022 |
Discovery of novel targets in a complex regional pain syndrome mouse model by transcriptomics: TNF and JAK-STAT pathways. | Discovery of novel targets in a complex regional pain syndrome mouse model by transcriptomics: TNF and JAK-STAT pathways. Pohóczky K, Kun J, Szentes N, Aczél T, Urbán P, Gyenesei A, Bölcskei K, Szőke É, Sensi S, Dénes Á, Goebel A, Tékus V, Helyes Z. | 08/13/2022 |
Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. | Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Hu Y, Zhang H, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Chen X, Li C, Wang Q, Huang X, Liu Y, Shi Y, Zhang X., Free PMC Article | 06/18/2022 |
TNF-alpha/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells. | TNF-α/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells. Xiong H, Chen Z, Zhao J, Li W, Zhang S. | 05/28/2022 |
Targeting TNFalpha produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice. | Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice. Jensen BK, McAvoy KJ, Heinsinger NM, Lepore AC, Ilieva H, Haeusler AR, Trotti D, Pasinelli P., Free PMC Article | 05/14/2022 |
TNF Signaling Acts Downstream of MiR-322/-503 in Regulating DM1 Myogenesis. | TNF Signaling Acts Downstream of MiR-322/-503 in Regulating DM1 Myogenesis. Li M, Xu F, Liu Z, Wang C, Zhao Y, Zhu G, Shen X., Free PMC Article | 04/30/2022 |