| The distribution of NMO-characteristic brain lesions corresponds to sites of high AQP4 expression in neuromyelitis optica | Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression.
Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR, Lennon VA. | 01/21/2010 |
| Significant increased expression levels of AQP1 and AQP4 were seen in Creutzfeldt-Jakob disease, but not in advanced Alzheimer's disease and diffuse Lewy body disease. | Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice.
Rodríguez A, Pérez-Gracia E, Espinosa JC, Pumarola M, Torres JM, Ferrer I. | 01/21/2010 |
| Restricted to astrocytes. Detectable in subpial and subependymal zone in normal condition. More intense in ischemic foci. May reflect participation in development of brain edema in human brains by playing role in water transport. | Enhanced expression of aquaporin 4 in human brain with infarction.
Aoki K, Uchihara T, Tsuchiya K, Nakamura A, Ikeda K, Wakayama Y. | 01/21/2010 |
| Unexpectedly high AQP4 levels in pilocytic astrocytomas and present AQP4 as tumor progression marker in WHO grade II-IV astrocytomas. | Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival.
Warth A, Simon P, Capper D, Goeppert B, Tabatabai G, Herzog H, Dietz K, Stubenvoll F, Ajaaj R, Becker R, Weller M, Meyermann R, Wolburg H, Mittelbronn M. | 01/21/2010 |
| aquaporin-4 has species-specific roles in astrocytes and a functional relationship with Connexin43 | New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43.
Nicchia GP, Srinivas M, Li W, Brosnan CF, Frigeri A, Spray DC. | 01/21/2010 |
| Only the presence of AQP1, but not AQP4, enhanced cell growth and migration, typical properties of gliomas, while AQP4 enhanced cell adhesion suggesting differential biological roles for AQP1 and AQP4 in glioma cell biology. | Expression and function of water channels (aquaporins) in migrating malignant astrocytes.
McCoy E, Sontheimer H., Free PMC Article | 01/21/2010 |
| These results in human fetal brain lend morphological support to the previous findings that aquaporin-1 and aquaporin-4 play different roles in the regulation of the water homeostasis of the brain. | Fetal development of membrane water channel proteins aquaporin-1 and aquaporin-4 in the human brain.
Gömöri E, Pál J, Abrahám H, Vajda Z, Sulyok E, Seress L, Dóczi T. | 01/21/2010 |