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    AQP4 aquaporin 4 [ Homo sapiens (human) ]

    Gene ID: 361, updated on 16-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain.

    The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain.
    Pati R, Palazzo C, Valente O, Abbrescia P, Messina R, Surdo NC, Lefkimmiatis K, Signorelli F, Nicchia GP, Frigeri A., Free PMC Article

    06/11/2022
    TNF-alpha induces AQP4 overexpression in astrocytes through the NF-kappaB pathway causing cellular edema and apoptosis.

    TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis.
    Lu H, Ai L, Zhang B., Free PMC Article

    05/7/2022
    Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders: A Target of Autoimmunity in the Central Nervous System.

    Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders: A Target of Autoimmunity in the Central Nervous System.
    Abe Y, Yasui M., Free PMC Article

    05/7/2022
    AQP4 labels a subpopulation of white matter-dependent glial radial cells affected by pediatric hydrocephalus, and its expression increased in glial microvesicles released to the cerebrospinal fluid in obstructive hydrocephalus.

    AQP4 labels a subpopulation of white matter-dependent glial radial cells affected by pediatric hydrocephalus, and its expression increased in glial microvesicles released to the cerebrospinal fluid in obstructive hydrocephalus.
    Castañeyra-Ruiz L, González-Marrero I, Hernández-Abad LG, Carmona-Calero EM, Pardo MR, Baz-Davila R, Lee S, Muhonen M, Borges R, Castañeyra-Perdomo A., Free PMC Article

    04/9/2022
    Disassembly and Mislocalization of AQP4 in Incipient Scar Formation after Experimental Stroke.

    Disassembly and Mislocalization of AQP4 in Incipient Scar Formation after Experimental Stroke.
    Banitalebi S, Skauli N, Geiseler S, Ottersen OP, Amiry-Moghaddam M., Free PMC Article

    03/12/2022
    Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma.

    Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma.
    Valente O, Messina R, Ingravallo G, Bellitti E, Zimatore DS, de Gennaro L, Abbrescia P, Pati R, Palazzo C, Nicchia GP, Trojano M, Signorelli F, Frigeri A., Free PMC Article

    03/5/2022
    Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder.

    Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder.
    Li J, Bazzi SA, Schmitz F, Tanno H, McDaniel JR, Lee CH, Joshi C, Kim JE, Monson N, Greenberg BM, Hedfalk K, Melamed E, Ippolito GC., Free PMC Article

    03/5/2022
    Pregnancy-Related Attack in Neuromyelitis Optica Spectrum Disorder With AQP4-IgG: A Single-Center Study and Meta-Analysis.

    Pregnancy-Related Attack in Neuromyelitis Optica Spectrum Disorder With AQP4-IgG: A Single-Center Study and Meta-Analysis.
    Deng S, Lei Q, Lu W., Free PMC Article

    02/26/2022
    Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.

    Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.
    Chen X, Ren Y, Zhang Y, Lu W.

    02/26/2022
    Aquaporin-4 Removal from the Plasma Membrane of Human Muller Cells by AQP4-IgG from Patients with Neuromyelitis Optica Induces Changes in Cell Volume Homeostasis: the First Step of Retinal Injury?

    Aquaporin-4 Removal from the Plasma Membrane of Human Müller Cells by AQP4-IgG from Patients with Neuromyelitis Optica Induces Changes in Cell Volume Homeostasis: the First Step of Retinal Injury?
    Netti V, Fernández J, Melamud L, Garcia-Miranda P, Di Giusto G, Ford P, Echevarría M, Capurro C.

    02/5/2022
    Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder.

    Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder.
    Tradtrantip L, Yeaman MR, Verkman AS., Free PMC Article

    01/29/2022
    Differential regulation of the water channel protein aquaporins in chondrocytes of human knee articular cartilage by aging.

    Differential regulation of the water channel protein aquaporins in chondrocytes of human knee articular cartilage by aging.
    Kyung BS, Jung KW, Yeo WJ, Seo HK, Lee YS, Suh DW., Free PMC Article

    01/29/2022
    Evaluation of AQP4/TRPV4 Channel Co-expression, Microvessel Density, and its Association with Peritumoral Brain Edema in Intracranial Meningiomas.

    Evaluation of AQP4/TRPV4 Channel Co-expression, Microvessel Density, and its Association with Peritumoral Brain Edema in Intracranial Meningiomas.
    Faropoulos K, Polia A, Tsakona C, Pitaraki E, Moutafidi A, Gatzounis G, Assimakopoulou M., Free PMC Article

    01/22/2022
    Dynamics of AQP4 upon exposure to seropositive patient serum before and after Rituximab therapy in Neuromyelitis Optica: A cell-based study.

    Dynamics of AQP4 upon exposure to seropositive patient serum before and after Rituximab therapy in Neuromyelitis Optica: A cell-based study.
    Saha S, Mukherjee S, Guha G, Mukhopadhyay D.

    01/8/2022
    Pathogenic antibodies to AQP4: Neuromyelitis optica spectrum disorder (NMOSD).

    Pathogenic antibodies to AQP4: Neuromyelitis optica spectrum disorder (NMOSD).
    Wright SK, Wassmer E, Vincent A.

    01/8/2022
    The role of AQP4 in the pathogenesis of depression, and possible related mechanisms.

    The role of AQP4 in the pathogenesis of depression, and possible related mechanisms.
    Genel O, Pariante CM, Borsini A.

    12/18/2021
    Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease.

    Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease.
    Ameli R, Guttmann CRG, Prieto JC, Rollot F, Palotai M, Vukusic S, Marignier R, Cotton F, Group Members for OFSEP Imaging Working Group, COPIL of OFSEP, NOMADMUS study group.

    12/4/2021
    Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus.

    Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus.
    Hiraldo-González L, Trillo-Contreras JL, García-Miranda P, Pineda-Sánchez R, Ramírez-Lorca R, Rodrigo-Herrero S, Blanco MO, Oliver M, Bernal M, Franco-Macías E, Villadiego J, Echevarría M., Free PMC Article

    11/27/2021
    MiR-196b Promotes the Invasion and Migration of Lung Adenocarcinoma Cells by Targeting AQP4.

    MiR-196b Promotes the Invasion and Migration of Lung Adenocarcinoma Cells by Targeting AQP4.
    Wu X, Wu G, Zhang H, Peng X, Huang B, Huang M, Ding J, Mao C, Peng C., Free PMC Article

    11/27/2021
    Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway.

    Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway.
    Du L, Xing Z, Tao B, Li T, Yang D, Li W, Zheng Y, Kuang C, Yang Q., Free PMC Article

    10/9/2021
    Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study.

    Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study.
    Wallensten J, Nager A, Åsberg M, Borg K, Beser A, Wilczek A, Mobarrez F., Free PMC Article

    09/25/2021
    Correlations of AQP4 expression and polymorphism with diabetic retinopathy.

    Correlations of AQP4 expression and polymorphism with diabetic retinopathy.
    Zhou X, Cheng FC, Wang HL.

    09/18/2021
    Aquaporin-4 polymorphisms predict amyloid burden and clinical outcome in the Alzheimer's disease spectrum.

    Aquaporin-4 polymorphisms predict amyloid burden and clinical outcome in the Alzheimer's disease spectrum.
    Chandra A, Farrell C, Wilson H, Dervenoulas G, De Natale ER, Politis M, Alzheimer's Disease Neuroimaging Initiative.

    09/4/2021
    Neuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort.

    Neuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort.
    Dahan A, Brilot F, Leventer R, Kornberg AJ, Dale RC, Yiu EM.

    08/28/2021
    Expression and significance of aquaporin-4 in thyroid carcinoma.

    Expression and significance of aquaporin-4 in thyroid carcinoma.
    Zhang YH, Cheng YH, Cai G, Zhang YJ.

    08/28/2021