| MMP-2 -1306 C-->T polymorphism may be associated with colorectal cancer development and invasion | A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer.
Xu E, Lai M, Lv B, Xing X, Huang Q, Xia X. | 01/21/2010 |
| in vitro findings suggest that the environment within the airways of patients with asthma enhances MMP-2 and -14 protein and activity by a complex interaction of transcriptional and posttranscriptional mechanisms, which may contribute to ASM migration. | Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration.
Henderson N, Markwick LJ, Elshaw SR, Freyer AM, Knox AJ, Johnson SR. | 01/21/2010 |
| matrix metalloproteinase-2 has a role in progression of breast carcinoma | A high serum matrix metalloproteinase-2 level is associated with an adverse prognosis in node-positive breast carcinoma.
Leppä S, Saarto T, Vehmanen L, Blomqvist C, Elomaa I. | 01/21/2010 |
| MMP-2 correlated negatively with fractional shortening & positively with LV dimension. Changes in the release & activity of MMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with hypertrophic cardiomyopathy. | Increased circulating matrix metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction.
Noji Y, Shimizu M, Ino H, Higashikata T, Yamaguchi M, Nohara A, Horita T, Shimizu K, Ito Y, Matsuda T, Namura M, Mabuchi H. | 01/21/2010 |
| These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2, which is an important proteolytic factor in lung remodeling. | Epimorphin expression in interstitial pneumonia.
Terasaki Y, Fukuda Y, Suga M, Ikeguchi N, Takeya M., Free PMC Article | 01/21/2010 |
| results suggest that matrix metalloproteinase 2 plays an important role in tumor invasion and metastasis | MMP-1 and MMP-2 expression in uterine leiomyosarcoma and correlation with different clinicopathologic parameters.
Bodner-Adler B, Bodner K, Kimberger O, Czerwenka K, Leodolter S, Mayerhofer K. | 01/21/2010 |
| Significantly increased activity of MMP-2 was recognized in tumors showing tenascin-C degradation. | Degradation of tenascin-C and activity of matrix metalloproteinase-2 are associated with tumor recurrence in early stage non-small cell lung cancer.
Cai M, Onoda K, Takao M, Kyoko IY, Shimpo H, Yoshida T, Yada I. | 01/21/2010 |
| design, synthesis and characterization of potent slow-binding inhibitors | Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases.
Bernardo MM, Brown S, Li ZH, Fridman R, Mobashery S. | 01/21/2010 |
| HIV-1 interaction with mannose receptor induces promotion of MMP-2 through mannose receptor-mediated intracellular signaling in astrocytes. | HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes.
López-Herrera A, Liu Y, Rugeles MT, He JJ. | 01/21/2010 |
| MMP-2 was significantly higher in cell extracts from pseudoxanthoma elasticum patients than in control cells, whereas differences were negligible in the culture media. | Dermal fibroblasts from pseudoxanthoma elasticum patients have raised MMP-2 degradative potential.
Quaglino D, Sartor L, Garbisa S, Boraldi F, Croce A, Passi A, De Luca G, Tiozzo R, Pasquali-Ronchetti I. | 01/21/2010 |
| Results suggest that MMP-2 might contribute in the pathogenesis of chronic kidney disease. | Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease.
Chang HR, Yang SF, Li ML, Lin CC, Hsieh YS, Lian JD. | 01/21/2010 |
| destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells. | Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay.
Mizumoto H, Saito T, Ashihara K, Nishimura M, Takehara M, Tanaka R, Ito E, Kudo R. | 01/21/2010 |
| potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-2 was reduced in women with menorrhagia | Reduced levels of VEGF-A and MMP-2 and MMP-9 activity and increased TNF-alpha in menstrual endometrium and effluent in women with menorrhagia.
Malik S, Day K, Perrault I, Charnock-Jones DS, Smith SK. | 01/21/2010 |
| an imbalance between the MMP-2 and TIMP-2, caused primarily by an increase in TIMP-2 activity, contributes to the pathogenesis of diabetic nephropathy. | An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy.
Han SY, Jee YH, Han KH, Kang YS, Kim HK, Han JY, Kim YS, Cha DR. | 01/21/2010 |
| These experiments identified a collagen-binding domain (CBD)-binding site on type I collagen and demonstrated that a corresponding synthetic peptide can inhibit hydrolysis of type I and IV collagens by competing CBD-mediated gelatin binding to MMP-2. | Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions.
Xu X, Chen Z, Wang Y, Bonewald L, Steffensen B., Free PMC Article | 01/21/2010 |
| MMP-2 status in stromal fibroblasts, not in tumor cells, was a significant prognostic factor associated with angiogenesis in NSCLC. | Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer.
Ishikawa S, Takenaka K, Yanagihara K, Miyahara R, Kawano Y, Otake Y, Hasegawa S, Wada H, Tanaka F. | 01/21/2010 |
| In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower. | Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer.
Inagaki N, Stern C, McBain J, Lopata A, Kornman L, Wilkinson D. | 01/21/2010 |
| furin can directly cleave the RXXR amino acid sequence in the propeptide domain of proMMP-2 leading to inactivation of the enzyme. | Furin directly cleaves proMMP-2 in the trans-Golgi network resulting in a nonfunctioning proteinase.
Cao J, Rehemtulla A, Pavlaki M, Kozarekar P, Chiarelli C. | 01/21/2010 |
| In artery samples in diabetic patients relative to nondiabetic patients, capillary density was reduced to 30%, VEGF expression was reduced by 48%; the expression and the gelatinolytic activity of MMP-2 and -9 were upregulated. | Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in human type 2 diabetic arterial vasculature.
Chung AW, Hsiang YN, Matzke LA, McManus BM, van Breemen C, Okon EB. | 01/21/2010 |
| Upregulation of matrix metalloproteinase-2 (MMP-2) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees. | Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinase expression via 3 mitogen-activated protein kinases and PI3K pathways during the early development of osteoarthritis.
Hsieh YS, Yang SF, Lue KH, Chu SC, Li TJ, Lu KH. | 01/21/2010 |
| The production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs, and plasminogen activators by gingival fibroblasts stimulated with lipopolysaccharides produced by periodontopathogens, are reported. | Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction.
Bodet C, Andrian E, Tanabe S, Grenier D. | 01/21/2010 |
| expression up-regulated in Helicobacter species-infected colon and bile duct epithelial cells and hepatocytes. | Expression of matrix metalloprotease-2, -7 and -9 on human colon, liver and bile duct cell lines by enteric and gastric Helicobacter species.
Yanagisawa N, Geironson L, Al-Soud WA, Ljungh S. | 01/21/2010 |
| Lysophosphatidic acid and sphingosine 1-phoshpate enhanced MMP-2 expression in mRNA, protein levels, and also enzymatic activity of cells of the EAhy926 human endothelial cell line. | Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells.
Wu WT, Chen CN, Lin CI, Chen JH, Lee H. | 01/21/2010 |
| MMP2 activity in human endothelial cells exposed to high glucose is inhibited by acetylsalicylic acid | Inhibitory effect of acetylsalicylic acid on matrix metalloproteinase - 2 activity in human endothelial cells exposed to high glucose.
Nicolae M, Tircol M, Alexandru D., Free PMC Article | 01/21/2010 |
| Loss of MMP-2, MMP-3 and FN in lichen planus may be associated with the destruction of the epidermal basal layer and these MMPs may be involved in the pathogenesis of interface dermatitis. | Expression of matrix metalloproteinases (MMP-2, MMP-3, and MMP-9) and fibronectin in lichen planus.
Gunduz K, Demireli P, Inanir I, Nese N. | 01/21/2010 |