Results confirm that patients with COPD exhibited more MMP-12 protein, and the -82G allele of SNP rs2276109 was more frequent in controls than in COPD patients group. On the other hand, no relationship between the mentioned genetic polymorphism and MMP-12 level was found. Nevertheless, the data, together with other findings, suggest that MMP-12 affects COPD development. | The role of MMP-12 gene polymorphism - 82 A-to-G (rs2276109) in immunopathology of COPD in polish patients: a case control study. Gilowska I, Majorczyk E, Kasper Ł, Bogacz K, Szczegielniak J, Kasper M, Kaczmarski J, Skomudek A, Czerwinski M, Sładek K., Free PMC Article | 08/24/2019 |
In active human systemic lupus erythematosus, MMP12 levels were lower and IFN-gamma higher compared to treated patients or healthy individuals. Hence, macrophage proteolytic truncation of IFN-gamma attenuates classical activation of macrophages as a prelude for resolving inflammation. | C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease. Dufour A, Bellac CL, Eckhard U, Solis N, Klein T, Kappelhoff R, Fortelny N, Jobin P, Rozmus J, Mark J, Pavlidis P, Dive V, Barbour SJ, Overall CM., Free PMC Article | 01/19/2019 |
rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing rheumatic heart disease in a Han population in Southern China. | Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population. Hu W, Ye Y, Yin Y, Sang P, Li L, Wang J, Wan W, Li R, Bai X, Xie Y, Meng Z., Free PMC Article | 12/22/2018 |
Studied association of matrix metallopeptidase 12 (MMP12) -82 A>G promoter single nucleotide polymorphism (SNP) with bronchial asthma in a Bulgarian population. Results suggest the variant G allele of the MMP12 -82 A>G promoter polymorphism might considered protective for development of bronchial asthma. | MMP12 -82 A>G Promoter Polymorphism in Bronchial Asthma in a Population of Central Bulgaria. Tacheva T, Dimov D, Aleksandrova E, Bialecka M, Gulubova M, Vlaykova T. | 10/27/2018 |
that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma | The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma. Han F, Zhang S, Zhang L, Hao Q. | 08/11/2018 |
MMP-12 (-82A/G) polymorphisms associate with obesity risk and its severity. | Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population. Boumiza S, Bchir S, Ben Nasr H, Abbassi A, Jacob MP, Norel X, Tabka Z, Chahed K., Free PMC Article | 08/4/2018 |
Significant association observed for MMP-12 (-1082 A/G) (OR 2.55; 95% CI 1.75 to 3.71) gene polymorphism and risk of ischemic stroke. [meta-analysis] | Association between matrix metalloproteinase family gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis of 29 studies. Misra S, Talwar P, Kumar A, Kumar P, Sagar R, Vibha D, Pandit AK, Gulati A, Kushwaha S, Prasad K. | 07/21/2018 |
Review/Meta-analysis: MMP-1 -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms are associated with ischemic stroke risk. | MMP Gene Polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and Ischemic Stroke: A Meta-Analysis. Zhang G, Li W, Guo Y, Li D, Liu Y, Xu S. | 07/7/2018 |
The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha. These findings suggest MMP12 involved in trophoblast invasion during the first trimester. | Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A. Hiden U, Eyth CP, Majali-Martinez A, Desoye G, Tam-Amersdorfer C, Huppertz B, Ghaffari Tabrizi-Wizsy N., Free PMC Article | 05/5/2018 |
In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling. | HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ., Free PMC Article | 04/28/2018 |
The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease | Effects of common functional MMP12 gene polymorphisms on PD in a Polish population. Białecka M, Kurzawski M, Vlaykova T, Tacheva T, Dziedziejko V, Pierzchlińska A, Droździk M. | 03/24/2018 |
The results of this study demonstrate that the gene expression of MMP9, MMP12, TIMP1 and TIMP2 was influenced by the addition of TGF-beta1. These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 in the vein wall pathology. | Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency. Serralheiro P, Cairrão E, Maia CJ, João M, Almeida CMC, Verde I. | 03/10/2018 |
M4 macrophages are a possible source for HDAC9 and MMP12 expression in advanced human carotid plaques. | Synergistic Expression of Histone Deacetylase 9 and Matrix Metalloproteinase 12 in M4 Macrophages in Advanced Carotid Plaques. Oksala NKJ, Seppälä I, Rahikainen R, Mäkelä KM, Raitoharju E, Illig T, Klopp N, Kholova I, Laaksonen R, Karhunen PJ, Hytönen VP, Lehtimäki T. | 01/20/2018 |
MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R surface levels. MMP12 production by these cells was induced by CSF2, and treatment with a CD200R ligand reduced CSF2-induced MMP12 production. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression. | Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R(low) Monocyte-Derived Cells in Periodontitis. Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, Nguyen Hoang AT, Johannsen G, Marsland BJ, Boström EA, Svensson M. | 12/30/2017 |
G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population | The G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population. Tacheva T, Dimov D, Aleksandrova E, Bialecka M, Gulubova M, Vlaykova T. | 10/14/2017 |
Data indicate that MMP1, MMP12 and PPARG and hsa-miR-31-5p, hsa-miR-224-5p, and hsa-miR-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity. | Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. Kuasne H, Barros-Filho MC, Busso-Lopes A, Marchi FA, Pinheiro M, Muñoz JJ, Scapulatempo-Neto C, Faria EF, Guimarães GC, Lopes A, Trindade-Filho JC, Domingues MA, Drigo SA, Rogatto SR., Free PMC Article | 09/2/2017 |
Increased levels of MMP1 and MMP12 on tumor-associated macrophages in the peripheral areas of dermatofibrosarcoma protuberance might contribute to local invasion | The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma Protuberans. Fujimura T, Kakizaki A, Sato Y, Tanita K, Furudate S, Aiba S. | 08/26/2017 |
Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3, MMP9, MMP12, and MMP13 were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B) expression. | Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. Kim S, Ahn SH, Lee JS, Song JE, Cho SH, Jung S, Kim SK, Kim SH, Lee KP, Kwon KS, Lee TH., Free PMC Article | 07/22/2017 |
We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1. | Matrix metalloproteinase12 facilitated platelet activation by shedding carcinoembryonic antigen related cell adhesion molecule1. Wang J, Ye Y, Wei G, Hu W, Li L, Lu S, Meng Z. | 06/24/2017 |
There were no statistically significant differences in the distribution of MMP7 -181 A/G and MMP12 -82 A/G genotype, allele, or haplotype frequencies between IRSA patients and controls, as well as patients' primary and secondary idiopathic recurrent spontaneous abortion | Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion. Barišić A, Pereza N, Hodžić A, Kapović M, Peterlin B, Ostojić S., Free PMC Article | 05/27/2017 |
To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 and MMP-13 expression, which is further controlled by NF-kappaB signaling. | Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κB Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. Park JW, Kim YJ, Shin IS, Kwon OK, Hong JM, Shin NR, Oh SR, Ha UH, Kim JH, Ahn KS. | 05/27/2017 |
This study demonstrated that the MMP-12 levels was significantly higher in patients with atheromatous plaques than in those without plaques. | Matrix Metalloproteinase Levels in Cervical and Intracranial Carotid Dolichoarteriopathies. Arslan Y, Arslan İB, Pekçevik Y, Şener U, Köse Ş, Zorlu Y. | 04/15/2017 |
High MMP12 expression is associated with gastric cancer. | Role of miR-647 in human gastric cancer suppression. Cao W, Wei W, Zhan Z, Xie D, Xie Y, Xiao Q., Free PMC Article | 04/15/2017 |
Study evaluated MMP-12 and TIMP-1, TIMP-2, TIMP-3, and TIMP-4 levels in 40 patients with asymptomatic and symptomatic critical carotid artery stenosis (CAS) with neurologic symptoms onset within the preceding 12 hours; results suggest that MMP-12 is related to critical CAS independently on symptoms, moreover, TIMP-3 and TIMP-4 seem to be specifically related to stroke | MMP-12 and TIMP Behavior in Symptomatic and Asymptomatic Critical Carotid Artery Stenosis. Del Porto F, Cifani N, Proietta M, Toni D, Taurino M. | 04/15/2017 |
MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans. | Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening. Liu SL, Bae YH, Yu C, Monslow J, Hawthorne EA, Castagnino P, Branchetti E, Ferrari G, Damrauer SM, Puré E, Assoian RK., Free PMC Article | 10/8/2016 |