| This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling | SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Harris NLE, Vennin C, Conway JRW, Vine KL, Pinese M, Cowley MJ, Shearer RF, Lucas MC, Herrmann D, Allam AH, Pajic M, Morton JP, Australian Pancreatic Cancer Genome Initiative, Biankin AV, Ranson M, Timpson P, Saunders DN., Free PMC Article | 09/30/2017 |
| The variant of PAI-2 gene was associated with coronary artery disease and recurrent coronary event risk in Chinese Han population, in Xinjiang. | Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population.
Li X, Luo JY, Zhang L, Yang YN, Xie X, Liu F, Chen BD, Ma YT., Free PMC Article | 07/16/2016 |
| SerpinB2 plays an important role in proteostas | SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.
Lee JA, Yerbury JJ, Farrawell N, Shearer RF, Constantinescu P, Hatters DM, Schroder WA, Suhrbier A, Wilson MR, Saunders DN, Ranson M., Free PMC Article | 04/30/2016 |
| a total of 500 ESCC cases and 500 matched controls in a Southwest China population were evaluated for six SNPs in the exons of three Serpin genes (SerpinB5, SerpinB2, and SerpinE1). | Association between SNPs in Serpin gene family and risk of esophageal squamous cell carcinoma.
Meng H, Guan X, Guo H, Xiong G, Yang K, Wang K, Bai Y. | 11/21/2015 |
| Polymorphisms in this fibrinolytic system gene are associated with recurrent spontaneous abortion in Sinhalese women, probably through impaired implantation. | Polymorphisms in the fibrinolytic pathway genes and the risk of recurrent spontaneous abortion.
Andraweera PH, Dekker GA, Thompson SD, Nowak RC, Jayasekara RW, Dissanayake VH, Roberts CT. | 08/1/2015 |
| PAI-2 was up-regulated in tensioned keloid fibroblasts and normal fibroblasts, but more so in keloid cells. Knockdown of PAI2 reduced cell proliferation in fibroblasts under tension. | Skin equivalent tensional force alters keloid fibroblast behavior and phenotype.
Suarez E, Syed F, Rasgado TA, Walmsley A, Mandal P, Bayat A. | 07/4/2015 |
| Soluble guanylate cyclase activators might alleviate or reverse vascular remodeling in pulmonary hypertension through the up-regulation of PAI-2. | The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2.
Zhang S, Zou L, Yang T, Yang Y, Zhai Z, Xiao F, Wang C. | 05/16/2015 |
| We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for serpinb2 | Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis.
Cox MB, Bowden NA, Scott RJ, Lechner-Scott J. | 11/8/2014 |
| A role for SERPINB2 in patients with head and neck squamous cell carcinoma. | SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer.
Huang Z, Li H, Huang Q, Chen D, Han J, Wang L, Pan C, Chen W, House MG, Nephew KP, Guo Z. | 11/8/2014 |
| Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels. | Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels.
Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE., Free PMC Article | 03/1/2014 |
| PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1. | The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.
O'Hara A, Howarth A, Varro A, Dimaline R., Free PMC Article | 09/21/2013 |
| SerpinB2 can be induced by lentiviral infection in vivo. | Induction of SerpinB2 and Th1/Th2 modulation by SerpinB2 during lentiviral infections in vivo.
Major LD, Partridge TS, Gardner J, Kent SJ, de Rose R, Suhrbier A, Schroder WA., Free PMC Article | 09/7/2013 |
| Low expression of PAI-2 serves as a novel marker of portal vein tumor embolism and poor prognosis for hepatocellular cancer. | Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma.
Zhou L, Jin Y, Cui QC, Jin KM, Zhou WX, Xing BC. | 08/31/2013 |
| Increased expression of SerpinB2 by an inflammatory stimulus is sufficient to generate structures that resemble secretory vesicles. | Secretion of SerpinB2 from endothelial cells activated with inflammatory stimuli.
Boncela J, Przygodzka P, Wyroba E, Papiewska-Pajak I, Cierniewski CS. | 06/15/2013 |
| PAI-2 expression may be negatively associated with the invasive potential of hepatocellular carcinoma (HCC). | Expression of plasminogen activator inhibitor-2 is negatively associated with invasive potential in hepatocellular carcinoma cells.
Jin Y, Zhou L, Jin KM, Xing BC. | 06/15/2013 |
| a model for the transcriptional control of the human PAI-2 gene | Regulation of the human plasminogen activator inhibitor type 2 gene: cooperation of an upstream silencer and transactivator.
Stringer B, Udofa EA, Antalis TM., Free PMC Article | 05/19/2012 |
| Data suggests that PAI-2, in endothelial cells induced with inflammatory stimuli, can inhibit proteasome and thus tilt the balance favoring proapoptotic signaling. | Association of plasminogen activator inhibitor type 2 (PAI-2) with proteasome within endothelial cells activated with inflammatory stimuli.
Boncela J, Przygodzka P, Papiewska-Pajak I, Wyroba E, Cierniewski CS., Free PMC Article | 03/31/2012 |
| High PAI-2 expression is associated with poor treatment response in colorectal carcinoma. | Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients.
Halamkova J, Kiss I, Pavlovsky Z, Tomasek J, Jarkovsky J, Cech Z, Tucek S, Hanakova L, Moulis M, Zavrelova J, Man M, Benda P, Robek O, Kala Z, Penka M. | 09/24/2011 |
| Plasminogen activator inhibitor-2 (PAI-2) secreted from activated mast cells induces alpha-smooth muscle actin (alpha-SMA) expression in dermal fibroblasts | Plasminogen activator inhibitor-2 (PAI-2) secreted from activated mast cells induces α-smooth muscle actin (α-SMA) expression in dermal fibroblasts.
Kim CD, Sohn KC, Lee SS, Lee JH, Kim S, Lee YH, Ryu EK, Park YS. | 09/17/2011 |
| Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in | Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer.
Cochran BJ, Croucher DR, Lobov S, Saunders DN, Ranson M., Free PMC Article | 09/10/2011 |
| Our results suggest that P. intermedia may contribute to periodontal tissue destruction by upregulating tPA and PAI-2 expression in hPDL cells via multiple signaling pathways. | Prevotella intermedia stimulates tissue-type plasminogen activator and plasminogen activator inhibitor-2 expression via multiple signaling pathways in human periodontal ligament cells.
Guan SM, He JJ, Zhang M, Shu L. | 08/20/2011 |
| The decrease in plasma PAI-2 observed in preeclampsia does not precede the clinical onset of the disease. | Maternal plasma plasminogen activator inhibitor-2 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy.
Akolekar R, Cruz Jde J, Penco JM, Zhou Y, Nicolaides KH. | 08/13/2011 |
| PAI-2 is capable of inhibiting uPA in the presence of PAI-1, particularly on adherent cells in the presence of vitronectin | Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: Implications for cellular proteolysis and adhesion in cancer.
Lobov S, Ranson M. | 04/30/2011 |
| Results describe periodontal treatment effects on gingival crevicular fluid (GCF) interleukin-6 (IL-6), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-2 (PAI-2), albumin levels in type 2 diabetic patients. | Gingival crevicular fluid IL-6, tPA, PAI-2, albumin levels following initial periodontal treatment in chronic periodontitis patients with or without type 2 diabetes.
Kardeşler L, Buduneli N, Çetinkalp S, Lappin D, Kinane DF. | 04/30/2011 |
| Suggest that while PAI-1 and PAI-2 function similarly in the control of cellular plasmin generation by t-PA, they may have disparate effects on the alternative functions of t-PA via modulation of its engagement with endocytosis receptors. | Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes.
Lee JA, Croucher DR, Ranson M. | 03/26/2011 |