| A novel role for p66Shc-ROS pathway in androgen-induced prostate cancer cell proliferation and a role in early prostate carcinogenesis. | Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells.
Veeramani S, Yuan TC, Lin FF, Lin MF., Free PMC Article | 01/21/2010 |
| in VSMCs exposed to hyperglycemia, IGF-I stimulation of Shc facilitates the transfer of Grb2 to p85 resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration | Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells.
Radhakrishnan Y, Maile LA, Ling Y, Graves LM, Clemmons DR., Free PMC Article | 01/21/2010 |
| Shc has an intrinsic phosphorylation-dependent gating mechanism where the SH2 domain adopts an open conformation only when tyrosine phosphorylation has occurred. | A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein.
George R, Schuller AC, Harris R, Ladbury JE. | 01/21/2010 |
| Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling | Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling.
Kraut-Cohen J, Muller WJ, Elson A. | 01/21/2010 |
| demonstrated that 8-isoprostane has a significant influence on p66Shc promoter methylation. In the control group and in patients with ESRD, increasing 8-isoprostane levels were linked to an elevated promoter methylation | Decreased p66Shc promoter methylation in patients with end-stage renal disease.
Geisel J, Schorr H, Heine GH, Bodis M, Hübner U, Knapp JP, Herrmann W. | 01/21/2010 |
| IL-15 but not IL-21 caused an increased phosphorylation of Shc and ERK1/2. | The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.
de Totero D, Meazza R, Capaia M, Fabbi M, Azzarone B, Balleari E, Gobbi M, Cutrona G, Ferrarini M, Ferrini S. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesMultiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.
Feigelson HS, Teras LR, Diver WR, Tang W, Patel AV, Stevens VL, Calle EE, Thun MJ, Bouzyk M. The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer.
Wagner K, Hemminki K, Grzybowska E, Klaes R, Butkiewicz D, Pamula J, Pekala W, Zientek H, Mielzynska D, Siwinska E, Försti A. Variation in the SHC1 gene and longevity in humans.
Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline Slagboom P, Westendorp RG, 'Long Life' Study Group. Association analysis of the SHC1 gene locus with longevity in the Japanese population.
Kamei H, Adati N, Arai Y, Yamamura K, Takayama M, Nakazawa S, Ebihara Y, Gondo Y, Akechi M, Noguchi T, Hirose N, Sakaki Y, Kojima T. | 03/13/2008 |
| Suggest new pathway for the induction of oxidative stress by AGEs involving FKHRL1 inactivation and MnSOD suppression via Ser-36 phosphorylation of p66(shc) in human kidney cells. | AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.
Cai W, He JC, Zhu L, Chen X, Striker GE, Vlassara H. | 01/21/2010 |
| Up-regulation of muscle p66(ShcA) relates to proteolysis rate, suggesting an involvement of this gene in muscle catabolic response in hypercatabolic traumatized patients. | Overexpression of the elongation factor 1A1 relates to muscle proteolysis and proapoptotic p66(ShcA) gene transcription in hypercatabolic trauma patients.
Bosutti A, Scaggiante B, Grassi G, Guarnieri G, Biolo G. | 01/21/2010 |
| p66 Shc may have a role in progression of colon cancer | p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer.
Grossman SR, Lyle S, Resnick MB, Sabo E, Lis RT, Rosinha E, Liu Q, Hsieh CC, Bhat G, Frackelton AR Jr, Hafer LJ. | 01/21/2010 |
| the adaptors Nck and ShcA influenced adherence of S. Typhimurium to non-phagocytic cells. | Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells.
Boyle EC, Brown NF, Brumell JH, Finlay BB. | 01/21/2010 |
| novel interplay between p66Shc and p52Shc in the control of T-cell fate | p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P, Baldari CT., Free PMC Article | 01/21/2010 |
| report novel investigations into the role of the mitochondrial import machinery on p66(Shc) activation, which highlight the energetic status of mitochondria as a crucial determinant of p66(Shc) function | Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.
Orsini F, Moroni M, Contursi C, Yano M, Pelicci P, Giorgio M, Migliaccio E. | 01/21/2010 |
| NCAM activates FGFR signaling in a manner distinct from FGF2 stimulation, and regulates ShcA phosphorylation by the concerted efforts of the NCAM/FGFR as well as the NCAM/Fyn signaling pathway. | ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation.
Hinsby AM, Lundfald L, Ditlevsen DK, Korshunova I, Juhl L, Meakin SO, Berezin V, Bock E. | 01/21/2010 |
| p66(shc) regulates mitochondrial oxidative capacity and may extend life span by repartitioning metabolic energy conversion away from oxidative and toward glycolytic pathways | The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism.
Nemoto S, Combs CA, French S, Ahn BH, Fergusson MM, Balaban RS, Finkel T. | 01/21/2010 |
| Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA | Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.
Kisielow M, Kleiner S, Nagasawa M, Faisal A, Nagamine Y., Free PMC Article | 01/21/2010 |
| p46 Shc expressed in the nucleus may play an important role in gastric carcinogenesis | Enhanced expression of p46 Shc in the nucleus and p52 Shc in the cytoplasm of human gastric cancer.
Yukimasa S, Masaki T, Yoshida S, Uchida N, Watanabe S, Usuki H, Yoshiji H, Maeta T, Ebara K, Nakatsu T, Kurokohchi K, Kuriyama S. | 01/21/2010 |
| Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues. | Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.
Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ. | 01/21/2010 |
| insulin receptor substrate-4 and ShcA have roles in signaling by the fibroblast growth factor receptor | Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.
Hinsby AM, Olsen JV, Mann M. | 01/21/2010 |
| p52Shc couples tyrosine kinase receptors to Ras by recruiting Grb2. | Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Patrussi L, Savino MT, Pellegrini M, Paccani SR, Migliaccio E, Plyte S, Lanfrancone L, Pelicci PG, Baldari CT. | 01/21/2010 |
| DDR2 autophosphorylation generates cytosolic domain phosphotyrosines that promote the formation of DDR2 cytosolic domain-Shc signaling complexes. | Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.
Yang K, Kim JH, Kim HJ, Park IS, Kim IY, Yang BS. | 01/21/2010 |
| CD9 activates the p46 Shc isoform in tumor cells and leads to apoptosis | CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.
Murayama Y, Miyagawa J, Oritani K, Yoshida H, Yamamoto K, Kishida O, Miyazaki T, Tsutsui S, Kiyohara T, Miyazaki Y, Higashiyama S, Matsuzawa Y, Shinomura Y. | 01/21/2010 |
| The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter | The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.
Ventura A, Luzi L, Pacini S, Baldari CT, Pelicci PG. | 01/21/2010 |
| p66shc may have a complex role in mammalian longevity: it is highly expressed in fibroblasts from centenarians | p66(shc) is highly expressed in fibroblasts from centenarians.
Pandolfi S, Bonafè M, Di Tella L, Tiberi L, Salvioli S, Monti D, Sorbi S, Franceschi C. | 01/21/2010 |
| Important variations in the p66Shc gene may be extremely rare and probably this gene is not involved in the genetic susceptibility to coronary artery disease. | Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease.
Sentinelli F, Romeo S, Barbetti F, Berni A, Filippi E, Fanelli M, Fallarino M, Baroni MG., Free PMC Article | 01/21/2010 |