| p97 does not provide the primary driving force for extracting the cholera toxin A1 chain from the endoplasmic reticulum | Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate.
Kothe M, Ye Y, Wagner JS, De Luca HE, Kern E, Rapoport TA, Lencer WI. | 01/21/2010 |
| valosin-containing protein (VCP) is an integral component of the endoplasmic reticulum associated degradation and cellular stress pathways induced by the unfolded protein response, which destroys the CFTR to cause cystic fibrosis | Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications.
Vij N, Fang S, Zeitlin PL. | 01/21/2010 |
| VCP (valosin-containing protein; p97) has a role in the control of N-glycosylation of proteins in the endoplasmic reticulum | A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum.
Lass A, McConnell E, Nowis D, Mechref Y, Kang P, Novotny MV, Wójcik C., Free PMC Article | 01/21/2010 |
| These results indicate that VCP is required for maintenance of normal endoplasmic reticulum structure and function and mediates the degradation of some proteins via the ubiquitin (Ub)-proteasome system. | Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells.
Wójcik C, Rowicka M, Kudlicki A, Nowis D, McConnell E, Kujawa M, DeMartino GN., Free PMC Article | 01/21/2010 |
| PBX1 plays a crucial role in valosin-containing protein (VCP) expression and function and the PBX-VCP pathway might be important for cell survival under cytokine stress | Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth.
Qiu Y, Tomita Y, Zhang B, Nakamichi I, Morii E, Aozasa K., Free PMC Article | 01/21/2010 |
| p97 can exert unfoldase activity in vitro, provided that a single tyrosine residue is introduced into the D1 pore and that the N domain is deleted. | Mutations in p97/VCP induce unfolding activity.
Rothballer A, Tzvetkov N, Zwickl P. | 01/21/2010 |
| p97/VCP is essential for degrading membrane-associated ubiquitinated proteins and that profound deficits in its ATPase activity severely affect ER quality control, leading to abnormal ER expansion and cell death | Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.
Kobayashi T, Tanaka K, Inoue K, Kakizuka A. | 01/21/2010 |
| VCP expression analysis is a useful prognosticator for PENs (pancreatic endocrine neoplasms). | Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms.
Yamamoto S, Tomita Y, Nakamori S, Hoshida Y, Iizuka N, Okami J, Nagano H, Dono K, Umeshita K, Sakon M, Ishikawa O, Ohigashi H, Aozasa K, Monden M. | 01/21/2010 |
| A 55-year-old German patient with inclusion body myopathy and frontotemporal dementia who harbors a heterozygous R155C missense mutation residing in the N-terminal CDC48 domain of VCP, which is involved in ubiquitin binding. | Mutant valosin-containing protein causes a novel type of frontotemporal dementia.
Schröder R, Watts GD, Mehta SG, Evert BO, Broich P, Fliessbach K, Pauls K, Hans VH, Kimonis V, Thal DR. | 01/21/2010 |
| VCP regulates NFKappaB pathway, which is important for metastasis of osteosarcoma | VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line.
Asai T, Tomita Y, Nakatsuka S, Hoshida Y, Myoui A, Yoshikawa H, Aozasa K., Free PMC Article | 01/21/2010 |
| VCP/CDC48 is required for transport of T cell-specific adapter protein into the eukaryotic nucleus | The p95-100 kDa ligand of the T cell-specific adaptor (TSAd) protein Src-homology-2 (SH2) domain implicated in TSAd nuclear import is p97 Valosin-containing protein (VCP).
Marti F, King PD. | 01/21/2010 |
| Functional characterizations indicate that VCP is not an Hsp90 substrate, but rather demonstrate the biochemical hallmarks of an Hsp90 co-chaperone | Evidence for chaperone heterocomplexes containing both Hsp90 and VCP.
Prince T, Shao J, Matts RL, Hartson SD. | 01/21/2010 |
| p97/valosin-containing protein ATPase activity is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif | ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.
Noguchi M, Takata T, Kimura Y, Manno A, Murakami K, Koike M, Ohizumi H, Hori S, Kakizuka A. | 01/21/2010 |
| Results suggest that the D2 domain of valosin-containing protein is involved in aggresome formation. | Dominant-negative effect of mutant valosin-containing protein in aggresome formation.
Kitami MI, Kitami T, Nagahama M, Tagaya M, Hori S, Kakizuka A, Mizuno Y, Hattori N. | 01/21/2010 |
| VCP-Atx-3 association is a potential target for therapeutic intervention and suggest that it might influence the progression of spinocerebellar ataxia type 3. | An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, Frank R, Hartl UF, Bonini NM, Wanker EE., Free PMC Article | 01/21/2010 |
| Our findings are consistent with the hypothesis that the pathology associated with VCP gene mutations is the result of impairment of ubiquitin-based degradation pathways. | Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.
Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, Tu PH, Watts GD, Markesbery WR, Smith CD, Kimonis VE. | 01/21/2010 |
| valosin-containing protein has a role in progression of colorectal carcinomas | Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis.
Yamamoto S, Tomita Y, Hoshida Y, Sakon M, Kameyama M, Imaoka S, Sekimoto M, Nakamori S, Monden M, Aozasa K. | 01/21/2010 |
| VCP is an essential target of Akt signaling | The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival.
Vandermoere F, El Yazidi-Belkoura I, Slomianny C, Demont Y, Bidaux G, Adriaenssens E, Lemoine J, Hondermarck H. | 01/21/2010 |
| These findings indicate that ELF2/NERF promotes VCP transcription and that ELF2/NERF-VCP pathway might be important for cell survival and proliferation under cytokine stress. | E74-like factor 2 regulates valosin-containing protein expression.
Zhang B, Tomita Y, Qiu Y, He J, Morii E, Noguchi S, Aozasa K. | 01/21/2010 |