| The forced expression of NDRG2 in ATL cells down-regulates not only the canonical pathway by inhibiting AKT signaling but also the non-canonical pathway by inducing NF-kappaB-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A | Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development.
Ichikawa T, Nakahata S, Fujii M, Iha H, Morishita K., Free PMC Article | 08/13/2016 |
| NIK(+) endothelial cells may play an important role in the persistence of synovitis | Nuclear Factor-κB-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study.
Maijer KI, Noort AR, de Hair MJ, van der Leij C, van Zoest KP, Choi IY, Gerlag DM, Maas M, Tak PP, Tas SW. | 06/11/2016 |
| Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells. | Mir-302c mediates influenza A virus-induced IFNβ expression by targeting NF-κB inducing kinase.
Gui S, Chen X, Zhang M, Zhao F, Wan Y, Wang L, Xu G, Zhou L, Yue X, Zhu Y, Liu S. | 05/14/2016 |
| TWEAK induces noncanonical NF-kappaB signaling and signal-specific regulation of NIK mRNA expression. | Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signaling.
Cherry EM, Lee DW, Jung JU, Sitcheran R., Free PMC Article | 02/6/2016 |
| by demonstrating a critical role of NIK in mediating NF-kappaB activation and BAG3 induction upon ST80/Bortezomib cotreatment, our study provides novel insights into mechanisms of resistance to proteotoxic stress in RMS | NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways.
Rapino F, Abhari BA, Jung M, Fulda S., Free PMC Article | 12/5/2015 |
| Loss-of-function mutations in NIK can cause B-cell lymphopenia, hypogammaglobulinemia, impaired ICOSL expression, and disordered T helper cell and NK cell function. | Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.
Willmann KL, Klaver S, Doğu F, Santos-Valente E, Garncarz W, Bilic I, Mace E, Salzer E, Conde CD, Sic H, Májek P, Banerjee PP, Vladimer GI, Haskoloğlu S, Bolkent MG, Küpesiz A, Condino-Neto A, Colinge J, Superti-Furga G, Pickl WF, van Zelm MC, Eibel H, Orange JS, Ikincioğulları A, Boztuğ K., Free PMC Article | 11/21/2015 |
| Membrane attack complexes activate noncanonical NF-kappaB by forming a novel Akt(+)NIK(+) signalosome on Rab5(+) endosomes. | Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes.
Jane-wit D, Surovtseva YV, Qin L, Li G, Liu R, Clark P, Manes TD, Wang C, Kashgarian M, Kirkiles-Smith NC, Tellides G, Pober JS., Free PMC Article | 11/21/2015 |
| Authors show that activation of NF-kappaB by Kaposi's sarcoma-associated herpesvirus K15 protein involves the recruitment of NF-kappaB-inducing kinase (NIK) and IKK alpha/beta to result in the phosphorylation of p65/RelA on Ser536. | Activation of NF-κB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-κB-inducing kinase, IκB kinases, and phosphorylation of p65.
Hävemeier A, Gramolelli S, Pietrek M, Jochmann R, Stürzl M, Schulz TF., Free PMC Article | 02/14/2015 |
| NIK plays a key role in constitutive NF-kappaB activation and the progression of ovarian cancer cells | NF-κB inducing kinase, a central signaling component of the non-canonical pathway of NF-κB, contributes to ovarian cancer progression.
Uno M, Saitoh Y, Mochida K, Tsuruyama E, Kiyono T, Imoto I, Inazawa J, Yuasa Y, Kubota T, Yamaoka S., Free PMC Article | 01/10/2015 |
| Identification and function of the NIK IAP binding motif, which promotes c-IAP1-dependent ubiquitylation of NIK. | Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1).
Lee S, Challa-Malladi M, Bratton SB, Wright CW., Free PMC Article | 01/3/2015 |
| These studies provide evidence for a role of NF-kappaB-inducing kinase (NIK) and subsequent non-canonical NF-kappaB signalling in pathological angiogenesis | NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.
Noort AR, van Zoest KP, Weijers EM, Koolwijk P, Maracle CX, Novack DV, Siemerink MJ, Schlingemann RO, Tak PP, Tas SW., Free PMC Article | 12/20/2014 |
| ARC is regulated via BIRC2/MAP3K14 signalling and its overexpression in AML or MSCs can function as a resistant factor to birinapant-induced leukaemia cell death. | Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia.
Mak PY, Mak DH, Ruvolo V, Jacamo R, Kornblau SM, Kantarjian H, Andreeff M, Carter BZ., Free PMC Article | 12/20/2014 |
| Results show that nuclear factor-kappa B inducing kinase has a role in graft-versus-host disease by maintaining the viability of activated alloreactive T lymphocytes. | Nuclear factor-kappaB inducing kinase is required for graft-versus-host disease.
Sánchez-Valdepeñas C, Casanova L, Colmenero I, Arriero M, González A, Lozano N, González-Vicent M, Díaz MA, Madero L, Fresno M, Ramírez M., Free PMC Article | 05/10/2014 |
| NIK is a new therapeutic target for Mantle cell lymphoma treatment, particularly for lymphomas that are refractory to B cell receptor pathway inhibitors. | Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B, Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D, Naylor T, Pfister E, Kovats S, Kim S, Dietze K, Dörken B, Steidl C, Tzankov A, Hummel M, Monahan J, Morrissey MP, Fritsch C, Sellers WR, Cooke VG, Gascoyne RD, Lenz G, Stegmeier F. | 03/22/2014 |
| A pivotal role for NIK in nuclear factor kappa B activation and regulation of gene expression in T-cell lymphoma. | NIK controls classical and alternative NF-κB activation and is necessary for the survival of human T-cell lymphoma cells.
Odqvist L, Sánchez-Beato M, Montes-Moreno S, Martín-Sánchez E, Pajares R, Sánchez-Verde L, Ortiz-Romero PL, Rodriguez J, Rodríguez-Pinilla SM, Iniesta-Martínez F, Solera-Arroyo JC, Ramos-Asensio R, Flores T, Palanca JM, Bragado FG, Franjo PD, Piris MA. | 11/16/2013 |
| TRAF2/NIK/NF-kappaB2 pathway regulates pancreatic ductal adenocarcinoma cell tumorigenicity | Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity.
Döppler H, Liou GY, Storz P., Free PMC Article | 08/31/2013 |
| APPL1 regulates basal NF-kappaB activity by modulating the stability of NIK, which affects the activation of p65. | APPL1 regulates basal NF-κB activity by stabilizing NIK.
Hupalowska A, Pyrzynska B, Miaczynska M., Free PMC Article | 05/11/2013 |
| we found that NIK and the noncanonical pathway are very prevalent in Hodgkin lymphoma | Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival.
Ranuncolo SM, Pittaluga S, Evbuomwan MO, Jaffe ES, Lewis BA., Free PMC Article | 01/5/2013 |
| study shows API2-MALT1 fusion oncoprotein induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK); resulting deregulated NIK activity is associated with constitutive noncanonical NF-kappaB signaling, enhanced B cell adhesion and apoptosis resistance | Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation.
Rosebeck S, Madden L, Jin X, Gu S, Apel IJ, Appert A, Hamoudi RA, Noels H, Sagaert X, Van Loo P, Baens M, Du MQ, Lucas PC, McAllister-Lucas LM., Free PMC Article | 11/24/2012 |
| a molecular basis for the recent observation of gain-of-function activity for an N-terminal deletion mutant (DeltaN324) of NIK, leading to constitutive non-canonical NF-kappaB signaling with enhanced B-cell adhesion and apoptosis resistance. | Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation.
Liu J, Sudom A, Min X, Cao Z, Gao X, Ayres M, Lee F, Cao P, Johnstone S, Plotnikova O, Walker N, Chen G, Wang Z., Free PMC Article | 11/17/2012 |
| NIK is one of the direct target genes of miR-520e. | MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK).
Zhang S, Shan C, Kong G, Du Y, Ye L, Zhang X. | 10/20/2012 |
| NIK mediates both beta-catenin and NF-kappaB regulated transcription to modulate melanoma survival and growth | NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.
Thu YM, Su Y, Yang J, Splittgerber R, Na S, Boyd A, Mosse C, Simons C, Richmond A., Free PMC Article | 09/1/2012 |
| Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma. | Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma.
Otto C, Giefing M, Massow A, Vater I, Gesk S, Schlesner M, Richter J, Klapper W, Hansmann ML, Siebert R, Küppers R. | 07/28/2012 |
| NIK activity in nonhematopoietic cells controls Th2 cell development and prevents eosinophil-driven inflammatory disease, most likely using a signaling pathway that operates independent of the known NIK substrate IKKalpha. | NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation.
Häcker H, Chi L, Rehg JE, Redecke V., Free PMC Article | 06/16/2012 |
| Cigarette smoke and TNFalpha increase NIK levels causing phosphorylation of IKKalpha, which leads to histone acetylation. | NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.
Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I., Free PMC Article | 01/21/2012 |