Nr4a1 nuclear receptor subfamily 4, group A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr4a1provided by MGI
Official Full Name: nuclear receptor subfamily 4, group A, member 1provided by MGI
Primary source: MGI:MGI:1352454
See related: Ensembl:ENSMUSG00000023034 AllianceGenome:MGI:1352454
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hmr; N10; TR3; Gfrp; Hbr1; NP10; TIS1; GFRP1; Hbr-1; NGFIB; nur77; NGFI-B; NUR77-1; NUR77-2
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in cellular response to corticotropin-releasing hormone stimulus; fat cell differentiation; and negative regulation of cell cycle. Acts upstream of or within several processes, including positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; and skeletal muscle cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including bone; genitourinary system; hemolymphoid system; nervous system; and submandibular gland primordium. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 65.6), thymus adult (RPKM 24.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.64 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101151783..101172676)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101253902..101274795)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NR4a1/2 deletion promotes accumulation of TCF1[+] stem-like precursors of exhausted CD8[+] T cells in the tumor microenvironment.
Title: NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment.
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Title: NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways.
Title: Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways.
Knockdown of NR4A1 alleviates doxorubicin-induced cardiotoxicity through inhibiting the activation of the NLRP3 inflammasome.
Title: Knockdown of NR4A1 alleviates doxorubicin-induced cardiotoxicity through inhibiting the activation of the NLRP3 inflammasome.
Orphan nuclear receptor 4 A1 involvement in transforming growth factor beta1-induced myocardial fibrosis in diabetic mice.
Title: Orphan nuclear receptor 4 A1 involvement in transforming growth factor beta1-induced myocardial fibrosis in diabetic mice.
Nur77 alleviates cardiac fibrosis by upregulating GSK-3beta transcription during aging.
Title: Nur77 alleviates cardiac fibrosis by upregulating GSK-3β transcription during aging.
NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration.
Title: NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration.
Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung.
Title: Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung.
Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis.
Title: Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis.
Oxidative stress impairs the Nur77-Sirt1 axis resulting in a decline in organism homeostasis during aging.
Title: Oxidative stress impairs the Nur77-Sirt1 axis resulting in a decline in organism homeostasis during aging.

Submit: New GeneRIF Correction See all GeneRIFs (209)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nr4a1 (e-PCR), detects polymorphism
- UniSTS:536539

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter secretion involved in regulation of skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in non-canonical inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to inorganic substance	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear receptor subfamily 4 group A member 1

Names: hormone receptor; nuclear hormone receptor NUR/77; nuclear protein N10; orphan nuclear receptor HMR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411253.1 → NP_001398182.1 nuclear receptor subfamily 4 group A member 1

Status: VALIDATED

Source sequence(s)

AC163018

UniProtKB/Swiss-Prot

P12813

UniProtKB/TrEMBL

Q545Q1

Related

ENSMUSP00000155225.2, ENSMUST00000228985.2
NM_001411254.1 → NP_001398183.1 nuclear receptor subfamily 4 group A member 1

Status: VALIDATED

Source sequence(s)

AC163018

UniProtKB/Swiss-Prot

P12813

UniProtKB/TrEMBL

Q545Q1
NM_010444.3 → NP_034574.1 nuclear receptor subfamily 4 group A member 1

See identical proteins and their annotated locations for NP_034574.1

Status: VALIDATED

Source sequence(s)

AC163018

Consensus CDS

CCDS27848.1

UniProtKB/Swiss-Prot

P12813

UniProtKB/TrEMBL

Q545Q1

Related

ENSMUSP00000023779.7, ENSMUST00000023779.8

Conserved Domains (2) summary

cd07348
Location:364 → 601

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:268 → 342

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

101151783..101172676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248339.2 → XP_030104199.1 nuclear receptor subfamily 4 group A member 1 isoform X1

UniProtKB/Swiss-Prot

P12813

UniProtKB/TrEMBL

Q545Q1

Conserved Domains (2) summary

cd07348
Location:364 → 601

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:268 → 342

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_017316436.3 → XP_017171925.1 nuclear receptor subfamily 4 group A member 1 isoform X1

UniProtKB/Swiss-Prot

P12813

UniProtKB/TrEMBL

Q545Q1

Conserved Domains (2) summary

cd07348
Location:364 → 601

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:268 → 342

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_006520459.5 → XP_006520522.1 nuclear receptor subfamily 4 group A member 1 isoform X1

See identical proteins and their annotated locations for XP_006520522.1

UniProtKB/Swiss-Prot

P12813

UniProtKB/TrEMBL

Q545Q1

Conserved Domains (2) summary

cd07348
Location:364 → 601

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:268 → 342

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_006520455.2 → XP_006520518.2 nuclear receptor subfamily 4 group A member 1 isoform X1

UniProtKB/Swiss-Prot

P12813

UniProtKB/TrEMBL

Q545Q1

Conserved Domains (2) summary

cd07348
Location:364 → 601

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:268 → 342

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B