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    Canx calnexin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29144, updated on 9-Oct-2021

    Summary

    Official Symbol
    Canxprovided by RGD
    Official Full Name
    calnexinprovided by RGD
    Primary source
    RGD:2266
    See related
    EnsemblRapid:ENSRNOG00000003343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    calcium-binding protein that may serve to chaperone proteins from the ER to outer cellular membrane [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 1097.7), Liver (RPKM 895.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Canx in Genome Data Viewer
    Location:
    10q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34623865..34656866, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35800942..35833939, complement)

    Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095091 Neighboring gene leukotriene C4 synthase Neighboring gene mastermind-like transcriptional coactivator 1 Neighboring gene uncharacterized LOC120095092 Neighboring gene chibby family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein H1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables apolipoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ionotropic glutamate receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum quality control compartment ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of presynaptic active zone membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in integral component of presynaptic active zone membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in integral component of presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172008.2NP_742005.1  calnexin precursor

      See identical proteins and their annotated locations for NP_742005.1

      Status: VALIDATED

      Source sequence(s)
      CB586187, EV776124, JACYVU010000219, L18889
      UniProtKB/Swiss-Prot
      P35565
      Conserved Domains (1) summary
      pfam00262
      Location:72441
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

      Range
      34623865..34656866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767680.3XP_008765902.1  calnexin isoform X1

      See identical proteins and their annotated locations for XP_008765902.1

      UniProtKB/Swiss-Prot
      P35565
      Related
      ENSRNOP00000040859.5, ENSRNOT00000049942.5
      Conserved Domains (1) summary
      pfam00262
      Location:72441
      Calreticulin; Calreticulin family
    2. XM_008767679.3XP_008765901.1  calnexin isoform X1

      See identical proteins and their annotated locations for XP_008765901.1

      UniProtKB/Swiss-Prot
      P35565
      Conserved Domains (1) summary
      pfam00262
      Location:72441
      Calreticulin; Calreticulin family
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