Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lyz1 lysozyme 1 [ Mus musculus (house mouse) ]

    Gene ID: 17110, updated on 25-Jan-2022

    Summary

    Official Symbol
    Lyz1provided by MGI
    Official Full Name
    lysozyme 1provided by MGI
    Primary source
    MGI:MGI:96902
    See related
    Ensembl:ENSMUSG00000069515 AllianceGenome:MGI:96902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lyz; Lyzf3; Lzp-s
    Summary
    Predicted to enable identical protein binding activity and lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Is expressed in embryo mesenchyme; liver and biliary system; and small intestine. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in large intestine adult (RPKM 3054.3), small intestine adult (RPKM 742.7) and 2 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lyz1 in Genome Data Viewer
    Location:
    10; 10 D2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117123700..117128773, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117287795..117292868, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (116724851..116729924, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530003J23 gene Neighboring gene lysozyme 2 Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene predicted gene, 40770

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysozyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi cis cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rough endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysozyme C-1
    Names
    1,4-beta-N-acetylmuramidase C
    P lysozyme structural
    lysozyme C type P
    lysozyme f3
    renal amyloidosis
    NP_038618.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013590.4NP_038618.1  lysozyme C-1 precursor

      See identical proteins and their annotated locations for NP_038618.1

      Status: VALIDATED

      Source sequence(s)
      BC061129, CD742179
      Consensus CDS
      CCDS48695.1
      UniProtKB/Swiss-Prot
      P17897
      UniProtKB/TrEMBL
      A0A077S9N1
      Related
      ENSMUSP00000089800.6, ENSMUST00000092162.7
      Conserved Domains (1) summary
      smart00263
      Location:19147
      LYZ1; Alpha-lactalbumin / lysozyme C

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      117123700..117128773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center