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    Icam2 intercellular adhesion molecule 2 [ Mus musculus (house mouse) ]

    Gene ID: 15896, updated on 5-Jan-2022

    Summary

    Official Symbol
    Icam2provided by MGI
    Official Full Name
    intercellular adhesion molecule 2provided by MGI
    Primary source
    MGI:MGI:96394
    See related
    Ensembl:ENSMUSG00000001029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD102; Ly-60; Icam-2
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Located in microvillus; plasma membrane; and uropod. Is integral component of plasma membrane. Is expressed in central nervous system; extraembryonic component; female reproductive system; retina; and vascular element. Orthologous to human ICAM2 (intercellular adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in lung adult (RPKM 101.8), thymus adult (RPKM 40.1) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Icam2 in Genome Data Viewer
    Location:
    11 E1; 11 69.09 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106268482..106278948, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106377656..106388139, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106238970..106243955, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CD79B antigen Neighboring gene sodium channel, voltage-gated, type IV, alpha Neighboring gene proline rich 29 Neighboring gene endoplasmic reticulum (ER) to nucleus signalling 1 Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene predicted gene, 36220

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in uropod IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    intercellular adhesion molecule 2
    Names
    lymphocyte function-associated AG-1 counter-receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010494.2NP_034624.1  intercellular adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_034624.1

      Status: VALIDATED

      Source sequence(s)
      AL604045, X65493
      Consensus CDS
      CCDS25555.1
      UniProtKB/Swiss-Prot
      P35330
      Related
      ENSMUSP00000001055.9, ENSMUST00000001055.15
      Conserved Domains (2) summary
      pfam03921
      Location:23114
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:112200
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106268482..106278948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248762.4XP_011247064.1  intercellular adhesion molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_011247064.1

      Conserved Domains (2) summary
      pfam03921
      Location:59150
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    2. XM_006532303.3XP_006532366.1  intercellular adhesion molecule 2 isoform X2

      See identical proteins and their annotated locations for XP_006532366.1

      UniProtKB/Swiss-Prot
      P35330
      Conserved Domains (2) summary
      pfam03921
      Location:23114
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:112200
      Ig; Immunoglobulin domain
    3. XM_011248763.4XP_011247065.1  intercellular adhesion molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_011247065.1

      Conserved Domains (2) summary
      pfam03921
      Location:59150
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    4. XM_030245595.2XP_030101455.1  intercellular adhesion molecule 2 isoform X2

      Conserved Domains (2) summary
      pfam03921
      Location:23114
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:112200
      Ig; Immunoglobulin domain
    5. XM_011248761.4XP_011247063.1  intercellular adhesion molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_011247063.1

      Conserved Domains (2) summary
      pfam03921
      Location:59150
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
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