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    Gldc glycine decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 104174, updated on 6-May-2021

    Summary

    Official Symbol
    Gldcprovided by MGI
    Official Full Name
    glycine decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:1341155
    See related
    Ensembl:ENSMUSG00000024827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D19Wsu57; b2b2679C; D19Wsu57e; b2b2679Clo; D030049L12Rik
    Expression
    Broad expression in liver adult (RPKM 46.0), kidney adult (RPKM 27.4) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gldc in Genome Data Viewer
    Location:
    19 C1; 19 24.87 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (30075841..30152841, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (30098441..30175441, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (30172937..30249908, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tumor protein D52-like 3 Neighboring gene ubiquitin-like, containing PHD and RING finger domains 2 Neighboring gene ribosomal protein L31, pseudogene 20 Neighboring gene mannose-binding lectin (protein C) 2 Neighboring gene protein dpy-30 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glycine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine dehydrogenase (decarboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glycine dehydrogenase (decarboxylating) activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of glycine cleavage complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of glycine cleavage complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycine dehydrogenase (decarboxylating), mitochondrial
    Names
    glycine cleavage system P protein
    glycine dehydrogenase (aminomethyl-transferring)
    glycine dehydrogenase [decarboxylating], mitochondrial
    NP_613061.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138595.2NP_613061.1  glycine dehydrogenase (decarboxylating), mitochondrial precursor

      See identical proteins and their annotated locations for NP_613061.1

      Status: VALIDATED

      Source sequence(s)
      AC157986, BC017135, BF020198
      Consensus CDS
      CCDS37956.1
      UniProtKB/Swiss-Prot
      Q91W43
      Related
      ENSMUSP00000025778.8, ENSMUST00000025778.9
      Conserved Domains (3) summary
      COG1003
      Location:509982
      GcvP2; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]
      PRK05367
      Location:621014
      PRK05367; glycine dehydrogenase; Provisional
      pfam02347
      Location:70493
      GDC-P; Glycine cleavage system P-protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      30075841..30152841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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