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    Mcrs1 microspherule protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 51812, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mcrs1provided by MGI
    Official Full Name
    microspherule protein 1provided by MGI
    Primary source
    MGI:MGI:1858420
    See related
    Ensembl:ENSMUSG00000037570 AllianceGenome:MGI:1858420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P78; MSP58; ICP22BP
    Summary
    Predicted to enable RNA binding activity and telomerase inhibitor activity. Predicted to be involved in histone H4 acetylation; positive regulation of protein localization to nucleolus; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within DNA recombination; DNA repair; and chromatin organization. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be part of Ino80 complex; MLL1 complex; and NSL complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 38.4), testis adult (RPKM 37.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F1; 15 56.09 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99140698..99149838, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99242817..99251961, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183 Neighboring gene STARR-seq mESC enhancer starr_39699 Neighboring gene predicted gene, 46538 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99082061-99082244 Neighboring gene STARR-positive B cell enhancer ABC_E1486 Neighboring gene STARR-positive B cell enhancer ABC_E7417 Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis. Ju JQ, et al. EMBO Rep, 2023 May 4. PMID 36951681, Free PMC Article
    2. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. Garrido A, et al. J Hepatol, 2022 Apr. PMID 34958836, Free PMC Article
    3. MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation. Fawal MA, et al. Dev Cell, 2015 Apr 6. PMID 25816988
    4. MCRS1 is essential for epiblast development during early mouse embryogenesis. Cui W, et al. Reproduction, 2020 Jan. PMID 31671403, Free PMC Article
    5. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. Ren Y, et al. Eur J Biochem, 1998 May 1. PMID 9654073

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.
      Title: Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.
    2. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
      Title: Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
    3. MCRS1 is essential for epiblast development during early mouse embryogenesis.
      Title: MCRS1 is essential for epiblast development during early mouse embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103140, MGC117915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microspherule protein 1
    Names
    58 kDa microspherule protein
    nucleolar protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164156.2 → NP_001157628.1  microspherule protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001157628.1

      Status: VALIDATED

      Source sequence(s)
      AC161198
      Consensus CDS
      CCDS49728.1
      UniProtKB/TrEMBL
      Q3TJY1, Q3TYU7
      Related
      ENSMUSP00000131407.2, ENSMUST00000163506.3
      Conserved Domains (2) summary
      cd00060
      Location:332 → 432
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:121 → 318
      MCRS_N; N-terminal region of micro-spherule protein

    2. NM_001411911.1 → NP_001398840.1  microspherule protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161198
      UniProtKB/Swiss-Prot
      O35255, Q32P11, Q99L90

    3. NM_016766.4 → NP_058046.2  microspherule protein 1 isoform 1

      See identical proteins and their annotated locations for NP_058046.2

      Status: VALIDATED

      Source sequence(s)
      AC161198
      Consensus CDS
      CCDS37199.1
      UniProtKB/Swiss-Prot
      O35255, Q32P11, Q99L90
      UniProtKB/TrEMBL
      Q3TYU7
      Related
      ENSMUSP00000043901.10, ENSMUST00000041190.17
      Conserved Domains (2) summary
      cd00060
      Location:345 → 445
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:134 → 331
      MCRS_N; N-terminal region of micro-spherule protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99140698..99149838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L90.1 GenPept UniProtKB/Swiss-Prot:Q99L90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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