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    Slc8b1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 [ Mus musculus (house mouse) ]

    Gene ID: 170756, updated on 16-Aug-2021

    Summary

    Official Symbol
    Slc8b1provided by MGI
    Official Full Name
    solute carrier family 8 (sodium/lithium/calcium exchanger), member B1provided by MGI
    Primary source
    MGI:MGI:2180781
    See related
    Ensembl:ENSMUSG00000032754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NC; NCKX; NCLX; Slc2; NCKX6; Slc24a6; AF261233
    Expression
    Broad expression in colon adult (RPKM 34.9), spleen adult (RPKM 21.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc8b1 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120649233..120672089)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120511168..120534024)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120961201..120984033)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine dehydratase-like Neighboring gene serine dehydratase Neighboring gene phospholipase B domain containing 2 Neighboring gene two pore channel 1 Neighboring gene IQ motif containing D Neighboring gene RBPJ interacting and tubulin associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in calcium export from the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in calcium export from the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium export from the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell membrane potential IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lymphocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial crista ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial sodium/calcium exchanger protein
    Names
    Na(+)/K(+)/Ca(2+)-exchange protein 6
    sodium/calcium exchanger protein, mitochondrial
    sodium/potassium/calcium exchanger 6, mitochondrial
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
    solute carrier family 24 member 6
    solute carrier family 8 member B1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177594.1NP_001171065.1  mitochondrial sodium/calcium exchanger protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001171065.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site, compared to variant 1. The resulting isoform (2) differs at an internal segment, compared to isoform 1.
      Source sequence(s)
      AC125183
      Consensus CDS
      CCDS51634.1
      UniProtKB/Swiss-Prot
      Q925Q3
      Related
      ENSMUSP00000107521.3, ENSMUST00000111890.9
      Conserved Domains (1) summary
      pfam01699
      Location:404557
      Na_Ca_ex; Sodium/calcium exchanger protein
    2. NM_001177595.1NP_001171066.1  mitochondrial sodium/calcium exchanger protein isoform 3 precursor

      See identical proteins and their annotated locations for NP_001171066.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AC125183
      Consensus CDS
      CCDS51633.1
      UniProtKB/Swiss-Prot
      Q925Q3
      Related
      ENSMUSP00000075428.6, ENSMUST00000076051.12
      Conserved Domains (2) summary
      pfam01699
      Location:103246
      Na_Ca_ex; Sodium/calcium exchanger protein
      cl01507
      Location:82118
      EIID-AGA; PTS system mannose/fructose/sorbose family IID component
    3. NM_133221.2NP_573484.2  mitochondrial sodium/calcium exchanger protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_573484.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF261233, AK028537, BP766040
      Consensus CDS
      CCDS39238.1
      UniProtKB/Swiss-Prot
      Q925Q3
      Related
      ENSMUSP00000064714.8, ENSMUST00000068326.14
      Conserved Domains (1) summary
      pfam01699
      Location:421574
      Na_Ca_ex; Sodium/calcium exchanger protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120649233..120672089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530174.1XP_006530237.1  mitochondrial sodium/calcium exchanger protein isoform X1

      Conserved Domains (1) summary
      PLN03151
      Location:63578
      PLN03151; cation/calcium exchanger; Provisional
    2. XM_006530175.2XP_006530238.1  mitochondrial sodium/calcium exchanger protein isoform X2

      Conserved Domains (1) summary
      PLN03151
      Location:63430
      PLN03151; cation/calcium exchanger; Provisional

    RNA

    1. XR_003955590.1 RNA Sequence

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