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    Sdsl serine dehydratase-like [ Mus musculus (house mouse) ]

    Gene ID: 257635, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sdslprovided by MGI
    Official Full Name
    serine dehydratase-likeprovided by MGI
    Primary source
    MGI:MGI:2182607
    See related
    Ensembl:ENSMUSG00000029596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SDS; TDH; SDH1; SDS-RS1; AI504310; 4432411H13Rik
    Expression
    Broad expression in adrenal adult (RPKM 41.3), duodenum adult (RPKM 15.9) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Sdsl in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120596258..120610890, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120458193..120472825, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120908211..120922772, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 27199 Neighboring gene predicted gene, 31976 Neighboring gene LIM homeobox protein 5 Neighboring gene serine dehydratase Neighboring gene phospholipase B domain containing 2 Neighboring gene solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-threonine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in isoleucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in threonine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    serine dehydratase-like
    Names
    L-serine deaminase
    L-serine dehydratase/L-threonine deaminase
    L-threonine dehydratase
    SDH
    serine dehydratase related sequence 1
    NP_001371183.1
    NP_598663.2
    XP_011246504.2
    XP_036021034.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384254.1NP_001371183.1  serine dehydratase-like

      Status: VALIDATED

      Source sequence(s)
      AC129553
      Related
      ENSMUSP00000031594.7, ENSMUST00000031594.13
      Conserved Domains (1) summary
      cd06448
      Location:17326
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
    2. NM_133902.3NP_598663.2  serine dehydratase-like

      See identical proteins and their annotated locations for NP_598663.2

      Status: VALIDATED

      Source sequence(s)
      AC129553
      Consensus CDS
      CCDS19618.1
      UniProtKB/Swiss-Prot
      Q8R238
      Related
      ENSMUSP00000058198.8, ENSMUST00000052258.14
      Conserved Domains (1) summary
      cd06448
      Location:17326
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120596258..120610890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248202.2XP_011246504.2  serine dehydratase-like isoform X1

      UniProtKB/Swiss-Prot
      Q8R238
      Conserved Domains (1) summary
      cd06448
      Location:17326
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
    2. XM_036165141.1XP_036021034.1  serine dehydratase-like isoform X2

      Conserved Domains (1) summary
      cl00342
      Location:20274
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
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