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    Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 [ Mus musculus (house mouse) ]

    Gene ID: 13085, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cyp2a12provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily a, polypeptide 12provided by MGI
    Primary source
    MGI:MGI:105055
    See related
    Ensembl:ENSMUSG00000060407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Restricted expression toward liver adult (RPKM 255.5) See more
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    Genomic context

    See Cyp2a12 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26728515..26736243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27029090..27036818)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (27814109..27821837)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450 2A8-like Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 22 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 21, pseudogene Neighboring gene predicted gene, 51444 Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene predicted gene, 29754

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables coumarin 7-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables steroid hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in coumarin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exogenous drug catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 2A12
    Names
    CYPIIA12
    cytochrome P450, 2a12
    steroid hormones 7-alpha-hydroxylase
    testosterone 7-alpha-hydroxylase
    NP_598418.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133657.1NP_598418.1  cytochrome P450 2A12 precursor

      See identical proteins and their annotated locations for NP_598418.1

      Status: VALIDATED

      Source sequence(s)
      BC018356
      Consensus CDS
      CCDS21009.1
      UniProtKB/Swiss-Prot
      P56593
      Related
      ENSMUSP00000074990.6, ENSMUST00000075552.7
      Conserved Domains (1) summary
      pfam00067
      Location:33489
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26728515..26736243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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