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    Pnoc prepronociceptin [ Mus musculus (house mouse) ]

    Gene ID: 18155, updated on 6-Jul-2021

    Summary

    Official Symbol
    Pnocprovided by MGI
    Official Full Name
    prepronociceptinprovided by MGI
    Primary source
    MGI:MGI:105308
    See related
    Ensembl:ENSMUSG00000045731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p; Np; N/O; N23; OFQ; N/OFQ; Npnc1; OFQ/N
    Summary
    This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in whole brain E14.5 (RPKM 9.2), CNS E14 (RPKM 8.2) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Pnoc in Genome Data Viewer
    Location:
    14; 14 D1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65638122..65663130, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65400673..65425564, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66019510..66044046, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene F-box protein 16 Neighboring gene predicted gene, 41178 Neighboring gene predicted gene, 48449 Neighboring gene zinc finger protein 395 Neighboring gene RIKEN cDNA 9530047P18 gene Neighboring gene elongator acetyltransferase complex subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables opioid peptide activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables opioid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    prepronociceptin
    Names
    neuropeptide nociceptin 1
    orphanin FQ
    proorphanin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205075.1NP_001192004.1  prepronociceptin isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001192004.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to variant 1. This results in a frameshift, and a longer isoform (2, also known as N27K) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC158983, AK045893
      Consensus CDS
      CCDS88690.1
      UniProtKB/Swiss-Prot
      Q64387
      UniProtKB/TrEMBL
      B7ZMX9, Q543U6
      Related
      ENSMUSP00000153589.2, ENSMUST00000224594.2
      Conserved Domains (1) summary
      pfam01160
      Location:2165
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. NM_010932.2NP_035062.1  prepronociceptin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_035062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1, also known as N23K).
      Source sequence(s)
      AC158983, AK045893
      Consensus CDS
      CCDS27213.1
      UniProtKB/Swiss-Prot
      Q64387
      UniProtKB/TrEMBL
      Q543U6
      Related
      ENSMUSP00000054210.6, ENSMUST00000059339.6
      Conserved Domains (1) summary
      pfam01160
      Location:2165
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      65638122..65663130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518684.4XP_006518747.1  prepronociceptin isoform X1

      See identical proteins and their annotated locations for XP_006518747.1

      UniProtKB/Swiss-Prot
      Q64387
      UniProtKB/TrEMBL
      B7ZMX9
      Conserved Domains (1) summary
      pfam01160
      Location:2165
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. XM_030247683.2XP_030103543.1  prepronociceptin isoform X2

      Conserved Domains (1) summary
      pfam01160
      Location:2165
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
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