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    Tead1 TEA domain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 21676, updated on 26-Jul-2021

    Summary

    Official Symbol
    Tead1provided by MGI
    Official Full Name
    TEA domain family member 1provided by MGI
    Primary source
    MGI:MGI:101876
    See related
    Ensembl:ENSMUSG00000055320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtrge; TEAD-; TEF-1; Tcf13; TEAD-1; mTEF-1; Gtrgeo5; 2610024B07Rik; B230114H05Rik
    Expression
    Broad expression in bladder adult (RPKM 16.6), heart adult (RPKM 14.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tead1 in Genome Data Viewer
    Location:
    7; 7 F1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (112278563..112505991)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (112679356..112906784)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (119822834..120050319)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene parvin, alpha Neighboring gene parvin, alpha, opposite strand Neighboring gene predicted gene, 24154 Neighboring gene predicted gene, 40451 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic heart tube morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lateral mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within notochord development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within paraxial mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within transition between fast and slow fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of TEAD-YAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription regulator complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcriptional enhancer factor TEF-1
    Names
    NTEF-1
    TCF-13
    transcription factor 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166584.2NP_001160056.2  transcriptional enhancer factor TEF-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), which results from the use of a non-AUG (AUU) translation initiation codon.
      Source sequence(s)
      AC104930, AK140307
      Consensus CDS
      CCDS52365.1
      Related
      ENSMUSP00000060671.11, ENSMUST00000059768.18
      Conserved Domains (1) summary
      smart00426
      Location:3097
      TEA; TEA domain
    2. NM_001166585.2NP_001160057.2  transcriptional enhancer factor TEF-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (3) lacks two internal protein segments compared to variant 1.
      Source sequence(s)
      AC104930, AK140307, BC060138
      Consensus CDS
      CCDS52367.1
      Related
      ENSMUSP00000081755.7, ENSMUST00000084705.13
      Conserved Domains (1) summary
      smart00426
      Location:3097
      TEA; TEA domain
    3. NM_009346.4NP_033372.2  transcriptional enhancer factor TEF-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (2) lacks an internal protein segment compared to isoform 1.
      Source sequence(s)
      AC104930, AK140307, AK148375
      Consensus CDS
      CCDS52366.1
      Related
      ENSMUSP00000159345.2, ENSMUST00000239404.2
      Conserved Domains (1) summary
      smart00426
      Location:3097
      TEA; TEA domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      112278563..112505991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175559.2: Suppressed sequence

      Description
      NM_175559.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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