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    Srgap2 SLIT-ROBO Rho GTPase activating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14270, updated on 16-Oct-2021

    Summary

    Official Symbol
    Srgap2provided by MGI
    Official Full Name
    SLIT-ROBO Rho GTPase activating protein 2provided by MGI
    Primary source
    MGI:MGI:109605
    See related
    Ensembl:ENSMUSG00000026425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBP2; Fnbp2; srGAP3; AI448945; 9930124L22Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 9.6), CNS E18 (RPKM 8.8) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Srgap2 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131212989..131455269, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131285251..131527531, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (133181828..133423938, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 5 Neighboring gene bystin-like pseudogene Neighboring gene predicted gene 28913 Neighboring gene inhibitor of kappaB kinase epsilon Neighboring gene predicted gene, 51644 Neighboring gene predicted gene, 53252 Neighboring gene family with sequence similarity 72, member A Neighboring gene arginine vasopressin receptor 1B Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly involved in ameboidal cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SLIT-ROBO Rho GTPase-activating protein 2
    Names
    FBP-27
    formin binding protein 2
    formin-binding protein 27

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081011.2NP_001074480.2  SLIT-ROBO Rho GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_001074480.2

      Status: VALIDATED

      Source sequence(s)
      AC165436, AK084412, BC030457, BY779945, CF164437
      Consensus CDS
      CCDS48355.1
      UniProtKB/Swiss-Prot
      Q91Z67
      Related
      ENSMUSP00000095195.3, ENSMUST00000097588.9
      Conserved Domains (3) summary
      cd07682
      Location:26289
      F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
      cd11955
      Location:732784
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:487674
      RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131212989..131455269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160225.1XP_036016118.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

      Related
      ENSMUSP00000139405.2, ENSMUST00000186543.7
      Conserved Domains (3) summary
      cd11955
      Location:732784
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:487674
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
      cl12013
      Location:26289
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001781100.2 RNA Sequence

    2. XR_004939453.1 RNA Sequence

    3. XR_001781103.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019520.1: Suppressed sequence

      Description
      NM_019520.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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