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    Gls2 glutaminase 2 (liver, mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 216456, updated on 18-May-2021

    Summary

    Official Symbol
    Gls2provided by MGI
    Official Full Name
    glutaminase 2 (liver, mitochondrial)provided by MGI
    Primary source
    MGI:MGI:2143539
    See related
    Ensembl:ENSMUSG00000044005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; GA; GLS; Lga; AI195532; A330074B06Rik
    Expression
    Biased expression in liver adult (RPKM 304.4) and liver E18 (RPKM 21.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gls2 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128030504..128045873)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128194635..128210004)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127631691..127647060)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif, single stranded interacting protein 2 Neighboring gene predicted gene 4556 Neighboring gene SPRY domain containing 4 Neighboring gene timeless circadian clock 1 Neighboring gene predicted gene, 26847 Neighboring gene major intrinsic protein of lens fiber

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4146

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glutamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutaminase liver isoform, mitochondrial
    Names
    L-glutaminase
    L-glutamine amidohydrolase
    liver mitochondrial glutaminase
    NP_001028436.2
    NP_001272706.1
    NP_001272708.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033264.3NP_001028436.2  glutaminase liver isoform, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001028436.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC135859, AK220231
      Consensus CDS
      CCDS24263.1
      UniProtKB/Swiss-Prot
      Q571F8
      Related
      ENSMUSP00000047376.7, ENSMUST00000044776.13
      Conserved Domains (4) summary
      sd00045
      Location:490516
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:490572
      Ank_2; Ankyrin repeats (3 copies)
      pfam17959
      Location:72155
      EF-hand_14; EF-hand domain
      pfam04960
      Location:177463
      Glutaminase
    2. NM_001285777.1NP_001272706.1  glutaminase liver isoform, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC135859
      Conserved Domains (4) summary
      cd00204
      Location:301389
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:17274
      Glutaminase; Glutaminase
      pfam13637
      Location:331383
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:301327
      ANK; ANK repeat [structural motif]
    3. NM_001285779.1NP_001272708.1  glutaminase liver isoform, mitochondrial isoform 3

      See identical proteins and their annotated locations for NP_001272708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC135859
      Conserved Domains (4) summary
      cd00204
      Location:225313
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:1198
      Glutaminase; Glutaminase
      pfam13637
      Location:255307
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:225251
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128030504..128045873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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