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    Dclk3 doublecortin-like kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 245038, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dclk3provided by MGI
    Official Full Name
    doublecortin-like kinase 3provided by MGI
    Primary source
    MGI:MGI:3039580
    See related
    Ensembl:ENSMUSG00000032500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dcamk; Dcamkl3; BC056929; C730036H08
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in kidney adult (RPKM 7.2), cortex adult (RPKM 6.3) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Dclk3 in Genome Data Viewer
    Location:
    9; 9 F3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (111268149..111318679)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111439081..111489611)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (111341585..111392115)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene EPM2A (laforin) interacting protein 1 Neighboring gene tetratricopeptide repeat and ankyrin repeat containing 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 36088 Neighboring gene src homology three (SH3) and cysteine rich domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase DCLK3
    Names
    CLICK-I and II-related
    CLr
    Click-I, -II related
    doublecortin and CaM kinase-like 3
    doublecortin-like and CAM kinase-like 3
    NP_766516.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172928.5NP_766516.2  serine/threonine-protein kinase DCLK3

      See identical proteins and their annotated locations for NP_766516.2

      Status: REVIEWED

      Source sequence(s)
      AV341123, BB617821, DQ286388
      Consensus CDS
      CCDS23585.2
      UniProtKB/Swiss-Prot
      Q8BWQ5
      Related
      ENSMUSP00000107510.4, ENSMUST00000111879.5
      Conserved Domains (3) summary
      smart00220
      Location:514771
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl00155
      Location:92177
      UBQ; Ubiquitin-like proteins
      cl21453
      Location:513770
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      111268149..111318679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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